Abstract:
BACKGROUND AND AIM:Nonalcoholic fatty liver diseases (NAFLD) are a clinical spectrum of disorders, of which nonalcoholic steatohepatitis (NASH) is the most strongly associated with inflammation. Inflammation is a known risk factor for low bone mass in the body. The primary goal of the present study was to evaluate the association between bone mineral density and liver function in patients with NASH. MATERIALS AND METHODS:Consenting patients with a diagnosis of NAFLD were included in the study. Extent of fatty change was graded based on ultrasonographic appearance (Grade 1, mild; Grade 2, moderate; Grade 3, severe). Bone mineral density was measured using the dual-energy x-ray absorptiometry method. ALT and hs-CRP were considered as noninvasive marker of NASH. According to ALT levels, patients were divided into two subgroups. RESULTS:A total of 102 patients with NAFLD and 54 healthy controls participated in the study. None of the patients with NAFLD had an abnormal bone mineral density. Furthermore, there was no difference between groups with regard to serum vitamin D levels. A subgroup analysis revealed that female patients with elevated serum ALT level had significantly lower bone mineral densities and higher hsCRP levels than female patients with normal ALT levels. The difference in vitamin D levels and body mass indices between the same subgroups was statistically insignificant. CONCLUSIONS:Simple steatosis of the liver does not affect bone mineral density. However, in a subgroup of patients with NAFLD, the presence of elevated serum ALT and hs-CRP levels, which are suggestive of NASH, was associated with lower bone mineral densities. Better understanding of the biological basis and the complex interactions between NAFLD and bone mass may help guide the clinical management of bone diseases associated with inflammation of the liver.
journal_name
Wien Klin Wochenschrjournal_title
Wiener klinische Wochenschriftauthors
Purnak T,Beyazit Y,Ozaslan E,Efe C,Hayretci Mdoi
10.1007/s00508-012-0211-4subject
Has Abstractpub_date
2012-08-01 00:00:00pages
526-31issue
15-16eissn
0043-5325issn
1613-7671journal_volume
124pub_type
杂志文章abstract::The life of Paul de Sorbait (1624-1691), who was Professor of Medicine, Dean of the Medical School, and Rector Magnificus at Vienna University, is reviewed on the occasion of the 300th anniversary of his death. ...
journal_title:Wiener klinische Wochenschrift
pub_type: 传,历史文章,杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::The present study reports the therapeutic results obtained by using neodym-YAG laser for the coagulation of tumours of the external genitals (n = 30), as well as for endoscopic laser treatment of tumours of the bladder (n = 32) and the urethra (n = 2). Despite the small number of cases, laser treatment of bladder tumo...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1984-01-20 00:00:00
abstract::We report our experience with primary angioplasty (PPTCA) in acute myocardial infarction performed without prior thrombolytic therapy. Between January 1991 and April 1993, 44 patients underwent PPTCA. Duration of symptoms was 163 +/ 106 min; age range of patients was 30 to 89 years (mean 60.6 +/- 13.5 years). Twelve p...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::A case of recurrent peroneal tendon subluxation is reported. Dynamic ultrasonography is the best imaging modality in the diagnosis of peroneal tendon subluxation. ...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-013-0435-y
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Therapeutic guidelines for treatment of late manifestations of Lyme borreliosis have not yet become well established. Patients with symptoms suggesting central nervous system involvement are often treated with courses of intravenous ceftriaxone. This is an expensive treatment approach with potentially severe...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-006-0698-7
更新日期:2006-11-01 00:00:00
abstract::Stool samples from 523 children aged between 3 months and 6 years were examined for Cryptosporidium parvum by means of the direct immunofluorescence technique in March 1996. The specimens were sent to the Federal Public Health Laboratory in Innsbruck from general practitioners and pediatricians and from hospitals in T...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::A 53-year-old man presented with a 19-month history of gastrointestinal bleeding. Repeated endoscopic investigation of the upper and lower intestine showed no source of bleeding. When the patient collapsed due to massive gastrointestinal hemorrhage he was referred to our center. Gastroscopy showed a large, bulging tum...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/BF03040474
更新日期:2003-09-30 00:00:00
abstract::Dietary fatty acids of the n-6 mainly linoleic acid (LA) series, and of the n-3, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) series both reduce plasma cholesterol levels and platelet responses to aggregating agents. The potency of n-3 fatty acids, which are present in relatively high concentrati...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:
更新日期:1989-04-14 00:00:00
abstract::A review and discussion of the incidence and clinical importance of various cardiac arrhythmias in patients with inflammatory diseases of the heart is presented in this paper. ...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1975-08-15 00:00:00
abstract::From the 1st of April 1974 till the 30th of September 1979 a consecutive series of 123 couples with a history of recurrent abortion was studied cytogenetically with modern banding techniques. 8 chromosomal aberrations were detected (6.5%); 3 women were found to be balanced reciprocal translocation carriers; the karyot...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1980-08-29 00:00:00
abstract::Hypersensitivity to allergens in tobacco leaf as a cause of occupational asthma in workers of the tobacco manufacturing industry has been reported previously. We describe the case of a female employee working in a tobacco plant with asthmatic symptoms occurring at the working place. The symptoms described by the patie...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Preoperative hyponatremia and thrombocytosis are associated with perioperative morbidity in patients with epithelial ovarian cancer (EOC). The aim of the present study was to evaluate preoperative hyponatremia and thrombocytosis as prognostic parameters in patients with EOC. METHODS:In a retrospective cohor...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-018-1388-y
更新日期:2018-10-01 00:00:00
abstract::Spinal subdural hematoma (SSDH) following spine surgery is an extremely rare condition, with only three cases being reported in the literature. Unintended durotomy has been associated with SSDH due to alterations of pressures in the dural compartments. The objective of the present report was to report two rare cases o...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-014-0632-3
更新日期:2015-01-01 00:00:00
abstract::In two groups of pts with diabetic derangements the effect of infusion therapy was investigated with regard to metabolic and endocrine functions. The rate of infusion was adapted to the height of the central venous pressure and the administration of electrolytes to their serum concentration. Insulin was withheld until...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:
更新日期:1980-09-12 00:00:00
abstract:BACKGROUND:In patients with ST-elevation myocardial infarction (STEMI), the relationship between transaminases and myocardial damage detected by cardiac magnetic resonance (CMR) imaging is unknown and the prognostic value incompletely investigated. MATERIALS AND METHODS:CMR imaging was performed in 167 STEMI patients ...
journal_title:Wiener klinische Wochenschrift
pub_type: 临床试验,杂志文章
doi:10.1007/s00508-015-0868-6
更新日期:2015-11-01 00:00:00
abstract::We report on a 64-year-old patient with a recurrent endometrial carcinoma which was associated with disseminated intravascular coagulation (DIC) and excessive hyperfibrinolysis. The patient presented with severe bleeding due to hypofibrinogenemia. Fibrin degradation products were excessively elevated and there were al...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1998-01-30 00:00:00
abstract::Antibiotic concentrations in postoperative wound secretions and in serum give some indication of the local and general effects of an antibiotic additive to bone cement. Ten patients received hip endoprostheses using a prepacked mixture of the bone cement Sulfix 6 with neomycin + bacitracin (Sulfix 6 A). After operatio...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1980-06-01 00:00:00
abstract::The importance of hypercholesterolemia for the development of atherosclerotic lesions is undebatable. It is less evident, however, whether the progression of established lesions can be influenced by modifying lipid levels. The review of seven controlled angiographic intervention trials shows that different criteria ar...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:
更新日期:1992-01-01 00:00:00
abstract::40 women with breast cancer were checked by the ultrasound Octoson technique and the results compared with the histological tumour types. We grouped the carcinomas into 3 types: scirrhous, solid or medullary, and the invasive lobular tumour. Our diagnostic ultrasound criteria: internal echoes, as well as contour and b...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1984-10-26 00:00:00
abstract::The serum hydroxyproline level enables a clinical assessment to be made of bone metabolism. A clinical-chemical method, which is described in detail, was applied in 50 control persons as well as in 76 patients with diseases of bones and/or joints. This method, which is a modification of the standard ion-exchange metho...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1981-03-06 00:00:00
abstract::Modern techniques in brachyradiotherapy using moulds are described for various tumours of the head and neck. The ideal dose distribution can be calculated by the use of computers and practical examples are shown. The radiobiological and also economical advantages of this method of treatment are discussed. ...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1980-02-15 00:00:00
abstract::The Poison Control Centre in Vienna registered 4018 inquires regarding possible poisoning in children over a two-year period. The peak incidence occurred in the age group between 2 and 3 years and poisoning chiefly took place in the mornings and in the afternoons, the most frequently ingested substances being househol...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1978-01-06 00:00:00
abstract::The influence of a 4 week course of balneotherapeutic treatment in Bad Hall on different blood parameters and on the activity of the antioxidative enzymes glutathione peroxidase (GSH-Px), catalase and superoxide dismutase (SOD) was examined in diabetics. The patients were divided into 2 groups. One group underwent an ...
journal_title:Wiener klinische Wochenschrift
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1991-01-01 00:00:00
abstract::Schönbauer's merits for the Society of Physicians in Vienna not only concern the renovation of its building after the Second World War but also his active scientific co-operation during four decades. His lectures are primarily devoted to abdominal surgery and neuro-surgery. ...
journal_title:Wiener klinische Wochenschrift
pub_type: 传,历史文章,杂志文章
doi:
更新日期:1988-12-02 00:00:00
abstract:AIM OF THE STUDY:To establish the prevalence of vertebral fractures according to age groups, sex and vertebral level in a sample of a Croatian urban population aged > or =50. We also tried to establish how many people had been diagnosed with osteoporosis by their family physician. PARTICIPANTS AND METHODS:Lateral thor...
journal_title:Wiener klinische Wochenschrift
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00508-004-0292-9
更新日期:2005-01-01 00:00:00
abstract::Gestational diabetes mellitus (GDM) is defined as a glucose tolerance disorder with onset during pregnancy and is associated with increased feto-maternal morbidity as well as long-term complications in mother and child. Women who fulfil the criteria of a manifest diabetes in early pregnancy (fasting plasma glucose >12...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:10.1007/s00508-018-1419-8
更新日期:2019-05-01 00:00:00
abstract::An attempt must be made to deal with the emotionally disturbed person in the test area of various social relationships, in order to learn to understand better the "language" of his symptoms. Moreover, Adler, Freud and Lorenz taught us to pay special attention to child development. This paper tries to project sexually ...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1980-12-19 00:00:00
abstract::Serum gastrin concentrations were measured in insulin-dependent diabetics and in patients who had undergone total duodenopancreatectomy and gastrectomy. Administration of somatostatin markedly inhibited gastrin release in the diabetic patients with an intact gastrointestinal tract. This inhibitory effect of somatostat...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1977-02-04 00:00:00
abstract:AIM:To determine the presence of vascular periodic acid-Schiff's reagent (PAS) positive deposits in the gastric and duodenal mucosa of diabetic patients and controls. METHODS:Forty-six poorly controlled diabetic patients with digestive symptoms, aged 23 to 63 years (32 type I patients on insulin therapy with a mean di...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:2001-03-15 00:00:00
abstract::The technique of exchange transfusion using a plastic catheter in the umbilical vein developed by Diamond and modified by Allen was instrumental in decreasing the mortality and morbidity in newborn infants with jaundice. Allen et al. demonstrated that the development of kernicterus in infants with erythroblastosis wit...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1990-08-31 00:00:00