Abstract:
:Targeting LRH-1: Virtual screening and molecular modeling were used to identify novel antagonists of liver receptor homolog-1 (LRH-1), an emerging therapeutic target for breast cancer. Hit compounds were synthesized and biologically assayed, and the preliminary results suggest that raloxifene-based analogues, substituted at the position C-7 of the benzothiophene ring, might generate an inactive protein conformation through binding and thus antagonize this nuclear receptor.
journal_name
ChemMedChemjournal_title
ChemMedChemauthors
Rey J,Hu H,Kyle F,Lai CF,Buluwela L,Coombes RC,Ortlund EA,Ali S,Snyder JP,Barrett AGdoi
10.1002/cmdc.201200307subject
Has Abstractpub_date
2012-11-01 00:00:00pages
1909-14issue
11eissn
1860-7179issn
1860-7187journal_volume
7pub_type
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