Abstract:
:Using the original approach, a series of metallated N-confused porphyrins and metallated porphyrins have been synthesized and characterized. For all the synthesized porphyrins, in vitro studies of cytotoxic activity against K562, U937, HL-60, Jurkat, A549 and HeLa cancer cell lines, the ability to induce apoptosis and effects on the cell cycle as well as the kinetics of proliferative activity of porphyrins and their respective metallated complexes in real time have been developed. The inhibitory activity of metallated porphyrins against human topoisomerase I and the possible mechanism of inhibition have been carried out by modelling using molecular docking.
journal_name
ChemMedChemjournal_title
ChemMedChemauthors
Halder N,Dzhemileva LU,Ramazanov IR,D'yakonov VA,Dzhemilev UM,Rath Hdoi
10.1002/cmdc.201900633subject
Has Abstractpub_date
2020-04-03 00:00:00pages
632-642issue
7eissn
1860-7179issn
1860-7187journal_volume
15pub_type
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