Abstract:
:Opening up ion channels: We synthesised a series of anthraquinone analogues, called the GoSlo-SR family. Their effects on bladder smooth muscle BK channels were examined and, as shown, shifted voltage dependent activation >-100 mV (at 10 μM). They were more efficacious than NS11021 and could provide a new scaffold for the design of efficacious BK openers.
journal_name
ChemMedChemjournal_title
ChemMedChemauthors
Roy S,Morayo Akande A,Large RJ,Webb TI,Camarasu C,Sergeant GP,McHale NG,Thornbury KD,Hollywood MAdoi
10.1002/cmdc.201200321subject
Has Abstractpub_date
2012-10-01 00:00:00pages
1763-9issue
10eissn
1860-7179issn
1860-7187journal_volume
7pub_type
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