Abstract:
:Greater than the sum of its parts: Artemisinins are currently in phase I-II clinical trials against breast, colorectal and non-small-cell lung cancers. In an attempt to offer increased specificity, a series of hybrid artemisinin-polypyrrole minor groove binder conjugates are described. DNA binding/modelling studies and preliminary biological evaluation give insights into their mechanism of action and the potential of this strategy.
journal_name
ChemMedChemjournal_title
ChemMedChemauthors
La Pensée L,Sabbani S,Sharma R,Bhamra I,Shore E,Chadwick AE,Berry NG,Firman J,Araujo NC,Cabral L,Cristiano ML,Bateman C,Janneh O,Gavrila A,Wu YH,Hussain A,Ward SA,Stocks PA,Cosstick R,O'Neill PMdoi
10.1002/cmdc.201200536subject
Has Abstractpub_date
2013-05-01 00:00:00pages
709-18issue
5eissn
1860-7179issn
1860-7187journal_volume
8pub_type
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