Abstract:
:The DATA chelators are a novel class of tri-anionic ligands based on 6-amino-1,4-diazepine-triacetic acid, which have been introduced recently for the chelation of (68)Ga. Compared with macrocyclic chelators based on the cyclen scaffold (i.e., DOTA, DO3A, and DO2A derivatives), DATA chelators undergo quantitative radiolabelling more rapidly and under milder conditions. In this study, a systematic evaluation of the labelling of four DATA chelators--DATA(M), DATA(P), DATA(Ph), and DATA(PPh)--with (68)Ga is presented. The results highlight the extraordinary potential of this new class of chelators for application in molecular imaging using (68)Ga positron emission tomography (PET).
journal_name
ChemMedChemjournal_title
ChemMedChemauthors
Seemann J,Waldron BP,Roesch F,Parker Ddoi
10.1002/cmdc.201500092subject
Has Abstractpub_date
2015-06-01 00:00:00pages
1019-26issue
6eissn
1860-7179issn
1860-7187journal_volume
10pub_type
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