Abstract:
:Dihydropyrimidine-based compounds belong to the first discovered inhibitors of the human mitotic kinesin Eg5. Although they are used by many research groups as model compounds for chemical genetics, considerably less emphasis has been placed on the improvement of this type of inhibitor, with the exception of two recent studies. Dihydropyrimidines can be divided into class I (analogues that bind in the S configuration) and class II type inhibitors, which bind in the R configuration. Herein we report the synthesis and optimization of novel class II type dihydropyrimidines using a combination of in vitro and docking techniques.
journal_name
ChemMedChemjournal_title
ChemMedChemauthors
Prokopcová H,Dallinger D,Uray G,Kaan HY,Ulaganathan V,Kozielski F,Laggner C,Kappe COdoi
10.1002/cmdc.201000252subject
Has Abstractpub_date
2010-10-04 00:00:00pages
1760-9issue
10eissn
1860-7179issn
1860-7187journal_volume
5pub_type
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