Abstract:
:Various structurally modified analogues of FR235222 (1), a natural tetrapeptide inhibitor of mammalian histone deacetylases, were prepared in a convergent approach. The design of the compounds was aimed to investigate the effect of structural modifications of the tetrapeptide core involved in enzyme binding in order to overcome some synthetic difficulties connected with the natural product 1. The modifications introduced could also help identify key structural features involved in the mechanism of action of these compounds. The prepared molecules were subjected to in vitro pharmacological tests, and their potency was tested on cultured cells. Two of the components of the array were found to be more potent than the parent compound 1 and almost as efficient as trichostatin A (TSA). These results demonstrate that it is possible to synthesize highly active cyclic tetrapeptides using commercially available amino acids (with the exception of 2-amino-8-oxodecanoic acid, Ahoda). The nature of the residue in the second position of the cyclic peptide and the stereochemistry of the Ahoda tail are important for the inhibitory activity of this class of cyclic tetrapeptide analogues.
journal_name
ChemMedChemjournal_title
ChemMedChemauthors
Gomez-Paloma L,Bruno I,Cini E,Khochbin S,Rodriquez M,Taddei M,Terracciano S,Sadoul Kdoi
10.1002/cmdc.200700095subject
Has Abstractpub_date
2007-10-01 00:00:00pages
1511-9issue
10eissn
1860-7179issn
1860-7187journal_volume
2pub_type
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