Abstract:
:Dopamine (DA) D(3) receptor antagonism might play a significant role in different therapeutic areas. A high number of preclinical studies on DA D(3) receptor antagonists have shown efficacy in animal models of Parkinson's disease, schizophrenia and drug dependence. This Review covers the activities of medicinal chemists in this field over the last ten years towards the identification of truly selective compounds. Both primary and patent literature is reviewed here. Since the original discoveries, a clear trend towards the optimization of the developability properties of the new scaffold has clearly emerged with time, from both academic and industrial researchers. Examples of advanced leads from academia and industry are described. The latest potential therapeutic applications are reported too.
journal_name
ChemMedChemjournal_title
ChemMedChemauthors
Micheli Fdoi
10.1002/cmdc.201000538subject
Has Abstractpub_date
2011-07-04 00:00:00pages
1152-62issue
7eissn
1860-7179issn
1860-7187journal_volume
6pub_type
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