Immunological basis of close-contact sensitization to osteosarcoma.

abstract：:Adaptive therapy seeks to exploit intra-tumoral competition to avoid, or at least delay, the emergence of therapy resistance in cancer. Motivated by promising results in prostate cancer, there is growing interest in extending this approach to other neoplasms. As such, it is urgent to understand the characteristics of ...

journal_title：Cancer research

authors： Strobl MAR,West J,Viossat Y,Damaghi M,Robertson-Tessi M,Brown JS,Gatenby RA,Maini PK,Anderson ARA

更新日期：2020-11-10 00:00:00

abstract：:Pancreatic cancer is an aggressive neoplasm with no current viable, effective treatment options. In the majority of cases, at first diagnosis, pancreatic cancer has already become metastatic so that conventional treatment regimens provide minimal, if any, clinical benefit in prolonging life or ameliorating the negativ...

journal_title：Cancer research

authors： Sarkar D,Su ZZ,Vozhilla N,Park ES,Randolph A,Valerie K,Fisher PB

更新日期：2005-10-01 00:00:00

abstract：:Focal adhesion kinase (FAK) and vascular endothelial growth factor receptor-3 (VEGFR-3) are protein tyrosine kinases that are overexpressed in human cancer and play an important role in survival signaling. In addition to its involvement with cell survival, VEGFR-3 is a primary factor in lymphatic angiogenesis. Because...

journal_title：Cancer research

authors： Garces CA,Kurenova EV,Golubovskaya VM,Cance WG

更新日期：2006-02-01 00:00:00

abstract：:P-glycoprotein (Pgp), a member of the ATP-binding cassette family of transporters, is an important mediator of multidrug resistance in cancer. Pgp exhibits a very broad specificity for substrates. These substrates share a common feature of being amphipathic and can orient into either leaflet of the membrane bilayer. C...

journal_title：Cancer research

authors： Chen Y,Pant AC,Simon SM

更新日期：2001-11-01 00:00:00

abstract：:We have previously shown that inoculation of human chromosome 3 (chr3)/A9 mouse fibrosarcoma microcell hybrids (MCHs) into severe combined immunodeficient (SCID) mice was followed by the regular elimination of some 3p regions whereas a 3q region was retained even after prolonged mouse passage. Using this approach, ref...

journal_title：Cancer research

authors： Kholodnyuk ID,Szeles A,Yang Y,Klein G,Imreh S

更新日期：2000-12-15 00:00:00

abstract：:Crude tissue or tumor extracts either do not contain sufficient inosine 5'-monophosphate dehydrogenase (IMPD) activity to be measured spectrophotometrically, or interfering enzyme activities prevent the use of a more sensitive radiochemical assay. A modified assay system which incorporates alpha, beta-methylene adenos...

journal_title：Cancer research

authors： Proffitt RT,Pathak VK,Villacorte DG,Presant CA

更新日期：1983-04-01 00:00:00

abstract：:Peripheral blood monocytes were isolated from normal human donors by separation on a continuous Percoll gradient and adherence to yield preparations of blood monocytes with a high degree of purity (greater than 99%). The monocytes were incubated in vitro with medium alone or with multilamellar liposomes that contained...

journal_title：Cancer research

authors： Kleinerman ES,Erickson KL,Schroit AJ,Fogler WE,Fidler IJ

更新日期：1983-05-01 00:00:00

abstract：:The paracrine influence of prostatic stromal cell proteins on a neoplastic prostate cell line (PA-III) was investigated. We have utilized an in vitro experimental model whereby confluent epithelial sheets of PA-III cells are grown on Matrigel-coated filters in bicameral chambers (Millicell-HA). Confluence of the epith...

journal_title：Cancer research

authors： Djakiew D,Tarkington MA,Lynch JH

更新日期：1990-03-15 00:00:00

abstract：:Intracavitary instillation of radioantibodies has been proposed as therapy for anatomically confined malignant disease. To evaluate this therapeutic strategy, a monoclonal antibody reactive with human transferrin receptor (7D3) was evaluated for localization in a human malignant mesothelioma transplanted i.p. in athym...

journal_title：Cancer research

authors： Griffin TW,Collins J,Bokhari F,Stochl M,Brill AB,Ito T,Emond G,Sands H

更新日期：1990-02-01 00:00:00

abstract：:IFN regulatory factor 8 (IRF8) is a key transcription factor for myeloid cell differentiation and its expression is frequently lost in hematopoietic cells of human myeloid leukemia patients. IRF8-deficient mice exhibit uncontrolled clonal expansion of undifferentiated myeloid cells that can progress to a fatal blast c...

journal_title：Cancer research

authors： Hu X,Yang D,Zimmerman M,Liu F,Yang J,Kannan S,Burchert A,Szulc Z,Bielawska A,Ozato K,Bhalla K,Liu K

更新日期：2011-04-15 00:00:00

abstract：:SUMO-1 conjugation modulates numerous cellular functions, including the subnuclear localization of its target proteins. The WT1 tumor suppressor encodes a four-zinc finger protein with distinct splicing isoforms. WT1(-KTS), encoding uninterrupted zinc fingers, functions as a transcription factor and has a diffusely nu...

journal_title：Cancer research

authors： Smolen GA,Vassileva MT,Wells J,Matunis MJ,Haber DA

更新日期：2004-11-01 00:00:00

abstract：:UV radiation has been shown to play a role in the initiation of human cutaneous melanoma, but its role in the development of malignant melanoma to the metastatic state is not very well defined. Although previous studies have concentrated on the effect of UV-B on the host immune response, the effect of UV-B on the tumo...

journal_title：Cancer research

authors： Singh RK,Gutman M,Reich R,Bar-Eli M

更新日期：1995-08-15 00:00:00

abstract：:The degree of heterogeneity among cancer stem cells (CSC) remains ill-defined and may hinder effective anti-CSC therapy. Evaluation of oral cancers for such heterogeneity identified two compartments within the CSC pool. One compartment was detected using a reporter for expression of the H3K4me3 demethylase JARID1B to ...

journal_title：Cancer research

authors： Facompre ND,Harmeyer KM,Sole X,Kabraji S,Belden Z,Sahu V,Whelan K,Tanaka K,Weinstein GS,Montone KT,Roesch A,Gimotty PA,Herlyn M,Rustgi AK,Nakagawa H,Ramaswamy S,Basu D

更新日期：2016-09-15 00:00:00

abstract：:Fluorescent-labeled hormones can be used to study hormone-receptor interactions by means of fluorescence polarization, visualization by fluorescence microscopy, or separation methods, e.g., dextran-coated charcoal. Subcellular fragments, single cells, and tissue preparations are amenable to study; in this work rat ute...

journal_title：Cancer research

authors： Dandliker WB,Brawn RJ,Hsu ML,Brawn PN,Levin J,Meyers CY,Kolb VM

更新日期：1978-11-01 00:00:00

abstract：:Several reports have suggested that a decrease or absence of adenosine deaminase complexing protein (ADCP) is consistently associated with cancer. However, in other studies, decreased as well as increased ADCP levels were found. In the present study, we investigated ADCP levels in 37 colorectal adenocarcinomas and cor...

journal_title：Cancer research

authors： ten Kate J,Wijnen JT,van der Goes RG,Quadt R,Griffioen G,Bosman FT,Khan PM

更新日期：1984-10-01 00:00:00

abstract：:To determine whether expression of the XPD/ERCC2 repair gene in trichothiodystrophy (TTD) group D cells could restore mutagenesis characteristics of repair-proficient cells, we compared the UV mutagenesis of normal cells, TTD group D cells, and TTD group D cells retrovirally transduced by the wild-type XPD/ERCC2 gene ...

journal_title：Cancer research

authors： Marionnet C,Quilliet X,Benoit A,Armier J,Sarasin A,Stary A

更新日期：1996-12-01 00:00:00

abstract：:Astrocytoma, the most common brain tumor in humans, is usually malignant and virtually incurable. Two types of malignant astrocytomas can be distinguished histopathologically: anaplastic astrocytoma and glioblastoma multiforme. Studies using DNA markers that detect restriction fragment length polymorphisms have shown ...

journal_title：Cancer research

authors： Fults D,Pedone CA,Thomas GA,White R

更新日期：1990-09-15 00:00:00

abstract：:Cell multiplication in the absence of integrin-derived adhesive signals (anchorage-independent growth) is the phenotypic hallmark of neoplastic transformation. Therefore, the frequently observed up-regulation of some integrins in tumors has been interpreted as an epiphenomenon and not as a causative factor of oncogeni...

journal_title：Cancer research

authors： Bertotti A,Comoglio PM,Trusolino L

更新日期：2005-12-01 00:00:00

abstract：:Luzopeptins consist of two identical, substituted quinolines linked to a cyclic decadepsipeptide, with a 2-fold symmetry. Luzopeptin A, with two acetylated sites in its peptide ring, is active against several experimental animal tumor systems. Luzopeptin B (one acetylated site) is less active, and luzopeptin C (no ace...

journal_title：Cancer research

authors： Huang CH,Crooke ST

更新日期：1985-08-01 00:00:00

abstract：:Milk from a number of species (e.g., man, mouse, rat, dog, and cow) contains inhibitors of the RNA-directed DNA polymerase. When attempts are made to isolate virions from the milk, part of the inhibitors follow the virions in the purification. The amount of inhibitors varies in different milk samples. These inhibitors...

journal_title：Cancer research

authors： Sanner T

更新日期：1976-02-01 00:00:00

abstract：:Alternative splicing is an important mechanism for the generation of protein diversity at a post-transcriptional level. Modifications in the splicing patterns of several genes have been shown to contribute to the malignant transformation of different tissue types. In this study, we used the Affymetrix Exon arrays to i...

journal_title：Cancer research

authors： Menghi F,Jacques TS,Barenco M,Schwalbe EC,Clifford SC,Hubank M,Ham J

更新日期：2011-03-15 00:00:00

abstract：:Cultured explants of mouse mammary gland were investigated for their capacity to secrete a cathepsin B-like cysteine proteinase. This enzyme had been shown previously to be secreted excessively from cultured explants of human breast tumors and spontaneous mouse mammary carcinomas. We now show that secretion is also ob...

journal_title：Cancer research

authors： Recklies AD,White C,Mitchell J,Poole AR

更新日期：1985-05-01 00:00:00

abstract：:The detection of tumor suppressor gene promoter methylation in sputum-derived exfoliated cells predicts early lung cancer. Here, we identified genetic determinants for this epigenetic process and examined their biologic effects on gene regulation. A two-stage approach involving discovery and replication was used to as...

journal_title：Cancer research

authors： Leng S,Stidley CA,Liu Y,Edlund CK,Willink RP,Han Y,Landi MT,Thun M,Picchi MA,Bruse SE,Crowell RE,Van Den Berg D,Caporaso NE,Amos CI,Siegfried JM,Tesfaigzi Y,Gilliland FD,Belinsky SA

更新日期：2012-02-01 00:00:00

abstract：:LMO2 is a transcription regulator involved in human T-cell leukemia, including some occurring in X-SCID gene therapy trials, and in B-cell lymphomas and prostate cancer. LMO2 functions in transcription complexes via protein-protein interactions involving two LIM domains and causes a preleukemic T-cell development bloc...

journal_title：Cancer research

authors： Appert A,Nam CH,Lobato N,Priego E,Miguel RN,Blundell T,Drynan L,Sewell H,Tanaka T,Rabbitts T

更新日期：2009-06-01 00:00:00

abstract：:Chemotherapy-induced peripheral neuropathy is a common, dose-limiting side effect of cancer treatment. This conference was the first of its kind to bring together a wide range of clinicians, researchers, and industry professionals to address the potential causes, preventions, and treatments for this drug toxicity. Int...

journal_title：Cancer research

authors： Smith JA,Benbow SJ

更新日期：2015-09-15 00:00:00

abstract：:Taxol is a novel antitumor agent with demonstrated efficacy against ovarian, breast, and non-small cell lung cancers in Phase II clinical trials, but which has been shown not to cross the blood-brain barrier. To adapt taxol as a therapy for brain tumors, we have incorporated it into a biodegradable polyanhydride matri...

journal_title：Cancer research

authors： Walter KA,Cahan MA,Gur A,Tyler B,Hilton J,Colvin OM,Burger PC,Domb A,Brem H

更新日期：1994-04-15 00:00:00

abstract：:Dilution end point loss of heterozygosity (LOH) analysis, a novel approach for the analysis of LOH, was used to evaluate allelic losses with the use of 21 highly polymorphic microsatellite markers at nine chromosomal sites most frequently affected in smoking-related non-small cell lung cancers. Allelotyping was done f...

journal_title：Cancer research

authors： Pan H,Califano J,Ponte JF,Russo AL,Cheng KH,Thiagalingam A,Nemani P,Sidransky D,Thiagalingam S

更新日期：2005-03-01 00:00:00

abstract：:Pancreatic neuroendocrine tumors (PanNET) were classified into grades (G) 1 to 3 by the World Health Organization in 2017, but the precise mechanisms of PanNET initiation and progression have remained unclear. In this study, we used a genetically engineered mouse model to investigate the mechanisms of PanNET formation...

journal_title：Cancer research

authors： Yamauchi Y,Kodama Y,Shiokawa M,Kakiuchi N,Marui S,Kuwada T,Sogabe Y,Tomono T,Mima A,Morita T,Matsumori T,Ueda T,Tsuda M,Nishikawa Y,Kuriyama K,Sakuma Y,Ota Y,Maruno T,Uza N,Masuda A,Tatsuoka H,Yabe D,Minamiguc

更新日期：2020-09-01 00:00:00

abstract：:Herpesvirus saimiri (HVS) was propagated in vero cells for 3 passages at 39 degrees and cloned 3 times at 34 degrees. This virus was inoculated into cotton-topped marmoset and squirrel monkeys; all inoculated monkeys became infected as HVS was reisolated after their circulating lymphocytes were cultured with vero cell...

journal_title：Cancer research

authors： Falk L,Wright J,Deinhardt F,Wolfe L,Schaffer P,Benyesh-Melnick M

更新日期：1976-02-01 00:00:00

abstract：:Twenty-seven patients with advanced cancer were entered in a phase I study of bolus i.v. 5-fluorouracil at a dose of 370 mg/m2/day for 5 days combined with a continuous i.v. infusion of (6S)-folinic acid for 5.5 days, starting 24 h in advance of the first 5-fluorouracil dose. The dose of (6S)-folinic acid was escalate...

journal_title：Cancer research

authors： Newman EM,Akman SA,Harrison JS,Leong LA,Margolin KA,Morgan RJ,Raschko JW,Somlo G,Ahn CW,Doroshow JH

更新日期：1992-05-01 00:00:00