Abstract:
OBJECTIVES:The purpose of the present study was to test the potential of colchicine, an agent with potent anti-inflammatory action, to reduce atrial fibrillation (AF) recurrence after pulmonary vein isolation in patients with paroxysmal AF. BACKGROUND:Proinflammatory processes induced by AF ablation therapy have been implicated in postablation arrhythmia recurrence. METHODS:Patients with paroxysmal AF who received radiofrequency ablation treatment were randomized to a 3-month course of colchicine 0.5 mg twice daily or placebo. C-reactive protein (CRP) and interleukin (IL)-6 levels were measured on day 1 and on day 4 of treatment. RESULTS:In the 3-month follow-up, recurrence of AF was observed in 27 (33.5%) of 80 patients of the placebo group versus 13 (16%) of 81 patients who received colchicine (odds ratio: 0.38, 95% confidence interval: 0.18 to 0.80). Gastrointestinal side-effects were the most common symptom among patients receiving active treatment. Diarrhea was reported in 7 patients in the colchicine group (8.6%) versus 1 in the placebo group (1.3%, p = 0.03). Colchicine led to higher reductions in CRP and IL-6 levels: the median difference of CRP and IL-6 levels between days 4 and 1 was -0.46 mg/l (interquartile range: -0.78 to 0.08 mg/l) and -0.10 mg/l (-0.30 to 0.10 pg/ml), respectively, in the placebo group versus -1.18 mg/l (-2.35 to -0.46 mg/l) and -0.50 pg/ml (-1.15 to -0.10 pg/ml) in the colchicine group (p < 0.01 for both comparisons). CONCLUSIONS:Colchicine is an effective and safe treatment for prevention of early AF recurrences after pulmonary vein isolation in the absence of antiarrhythmic drug treatment. This effect seems to be associated strongly with a significant decrease in inflammatory mediators, including IL-6 and CRP.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Deftereos S,Giannopoulos G,Kossyvakis C,Efremidis M,Panagopoulou V,Kaoukis A,Raisakis K,Bouras G,Angelidis C,Theodorakis A,Driva M,Doudoumis K,Pyrgakis V,Stefanadis Cdoi
10.1016/j.jacc.2012.07.031subject
Has Abstractpub_date
2012-10-30 00:00:00pages
1790-6issue
18eissn
0735-1097issn
1558-3597pii
S0735-1097(12)03033-1journal_volume
60pub_type
杂志文章,多中心研究,随机对照试验abstract:OBJECTIVES:We present a new method in which a priori knowledge of the blood velocity fields within the boundary layer at the vessel wall, combined with acquisition of high resolution magnetic resonance imaging (MRI) blood velocity data, allow exact modeling at the subpixel level. BACKGROUND:Methods are lacking for acc...
journal_title:Journal of the American College of Cardiology
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journal_title:Journal of the American College of Cardiology
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更新日期:2002-02-06 00:00:00
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更新日期:2006-02-21 00:00:00
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更新日期:2006-02-07 00:00:00
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更新日期:2019-11-26 00:00:00
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