当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > Benefit of early statin therapy in patients with acute myocardial infarction who have extremely low low-density lipoprotein cholesterol.

Benefit of early statin therapy in patients with acute myocardial infarction who have extremely low low-density lipoprotein cholesterol.

Abstract：

OBJECTIVES:We investigated whether statin therapy could be beneficial in patients with acute myocardial infarction (AMI) who have baseline low-density lipoprotein cholesterol (LDL-C) levels below 70 mg/dl. BACKGROUND:Intensive lipid-lowering therapy with a target LDL-C value <70 mg/dl is recommended in patients with very high cardiovascular risk. However, whether to use statin therapy in patients with baseline LDL-C levels below 70 mg/dl is controversial. METHODS:We analyzed 1,054 patients with AMI who had baseline LDL-C levels below 70 mg/dl and survived at discharge from the Korean Acute MI Registry between November 2005 and December 2007. They were divided into 2 groups according to the prescribing of statins at discharge (statin group n = 607; nonstatin group n = 447). The primary endpoint was the composite of 1-year major adverse cardiac events, including death, recurrent MI, target vessel revascularization, and coronary artery bypass grafting. RESULTS:Statin therapy significantly reduced the risk of the composite primary endpoint (adjusted hazard ratio [HR]: 0.56; 95% confidence interval [CI]: 0.34 to 0.89; p = 0.015). Statin therapy reduced the risk of cardiac death (HR: 0.47; 95% CI: 0.23 to 0.93; p = 0.031) and coronary revascularization (HR: 0.45, 95% CI: 0.24 to 0.85; p = 0.013). However, there were no differences in the risk of the composite of all-cause death, recurrent MI, and repeated percutaneous coronary intervention rate. CONCLUSIONS:Statin therapy in patients with AMI with LDL-C levels below 70 mg/dl was associated with improved clinical outcome.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Lee KH,Jeong MH,Kim HM,Ahn Y,Kim JH,Chae SC,Kim YJ,Hur SH,Seong IW,Hong TJ,Choi DH,Cho MC,Kim CJ,Seung KB,Chung WS,Jang YS,Rha SW,Bae JH,Cho JG,Park SJ,KAMIR (Korea Acute Myocardial Infarction Registry) Investigat

doi

10.1016/j.jacc.2011.05.057

subject

Has Abstract

pub_date

2011-10-11 00:00:00

pages

1664-71

issue

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(11)02767-7

journal_volume

pub_type

杂志文章,多中心研究

在线工具

Benefit of early statin therapy in patients with acute myocardial infarction who have extremely low low-density lipoprotein cholesterol.