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In vivo effects of nonionic and ionic contrast media on beta-thromboglobulin and fibrinopeptide levels.

Abstract：

:Nonionic contrast media are suggested to cause increased thromboembolism (in vivo), platelet aggregation and procoagulant effect (in vitro) as compared with ionic contrast media. To study these effects in vivo, 30 consecutive patients undergoing routine angiography were prospectively randomized to three groups of 10 patients each. Group A received diatrizoate (ionic, high osmolality), Group B ioxaglate (ionic, low osmolality) and Group C iohexol (nonionic, low osmolality). In vivo platelet alpha-granule release and fibrin-1 formation were measured by radioimmunoassay of beta-thromboglobulin and fibrinopeptide A in peripheral venous samples. Levels were estimated at three stages during the procedure: before and after left ventriculography and after coronary angiography. No differences were noted (p = NS) when the ratios of beta-thromboglobulin and fibrinopeptide A were compared among the three groups. These data suggest that the newer nonionic contrast media do not demonstrate enhanced systemic platelet activation or fibrin formation as compared with standard ionic contrast media. However, larger randomized clinical studies are necessary to conclusively establish the suggested thromboembolic potential of nonionic contrast media.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Arora R,Khandelwal M,Gopal A

doi

10.1016/0735-1097(91)90643-n

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

1533-6

issue

7

eissn

0735-1097

issn

1558-3597

pii

0735-1097(91)90643-N

journal_volume

17

pub_type

临床试验,杂志文章,随机对照试验

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