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The early repolarization pattern in the general population: clinical correlates and heritability.

Abstract：

OBJECTIVES:This study sought to describe the clinical correlates and heritability of the early repolarization pattern (ERP) in 2 large, population-based cohorts. BACKGROUND:There is growing recognition that ERP is associated with adverse outcomes. METHODS:Participants of the Framingham Heart Study (FHS) (N = 3,995) and the Health 2000 Survey (H2K) (N = 5,489) were included. ERP was defined as a J-point elevation ≥0.1 mV in ≥2 leads in either the inferior (II, III, aVF) or lateral (I, aVL, V(4-6)) territory or both. We tested the association between clinical characteristics and ERP, and estimated sibling recurrence risk. RESULTS:ERP was present in 243 of 3,955 (6.1%) of FHS and 180 of 5,489 (3.3%) of H2K subjects. Male sex, younger age, lower systolic blood pressure, higher Sokolow-Lyon index, and lower Cornell voltage were independently associated with the presence of ERP. In the FHS sample, siblings of individuals with ERP had an ERP prevalence of 11.6% (recurrence risk ratio of 1.89). Siblings of individuals with ERP had an increased unadjusted odds of ERP (odds ratio: 2.22, 95% confidence interval: 1.01 to 4.85, p = 0.047). CONCLUSIONS:ERP has strong association with clinical factors and has evidence for a heritable basis in the general population. Further assessment of the genetic determinants of ERP is warranted.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Noseworthy PA,Tikkanen JT,Porthan K,Oikarinen L,Pietilä A,Harald K,Peloso GM,Merchant FM,Jula A,Väänänen H,Hwang SJ,O'Donnell CJ,Salomaa V,Newton-Cheh C,Huikuri HV

doi

10.1016/j.jacc.2011.04.003

subject

Has Abstract

pub_date

2011-05-31 00:00:00

pages

2284-9

issue

22

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(11)01262-9

journal_volume

57

pub_type

杂志文章

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