Abstract:
BACKGROUND:Persistent organic pollutants (POPs) have been associated with type 2 diabetes (T2D), but causality is uncertain. OBJECTIVE:Within longitudinal population-based data from northern Sweden, we assessed how POPs associated with T2D prospectively and cross-sectionally, and further investigated factors related to individual changes in POP concentrations. METHODS:For 129 case-controls pairs matched by age, sex and date of sampling, plasma concentrations of hexachlorobenzene (HCB), dichlorodiphenyl-dichloroethylene (p,p'-DDE), dioxin-like (DL) polychlorinated biphenyl congeners (PCB-118 and PCB-156), and non-dioxin like (NDL-PCB: PCB-74, -99, -138 -153, -170, -180, -183 and PCB-187) were analyzed twice (baseline and follow-up, 9-20 years apart). The cases received their T2D diagnose between baseline and follow-up. Prospective (using baseline data) and cross-sectional (using follow-up data) odds ratios (ORs) for T2D on lipid standardized POPs (HCB, p,p'-DDE, ∑DL-PCBs, ∑NDL-PCBs) were estimated using conditional logistic regression, adjusting for body mass index (BMI) and plasma lipids. The influence of BMI, weight-change, and plasma lipids on longitudinal changes in POP concentrations were evaluated among non-diabetic individuals (n = 306). RESULTS:POPs were associated with T2D in both the prospective and cross-sectional assessments. Of a standard deviation increase in POPs, prospective ORs ranged 1.42 (95% CI: 0.99, 2.06) for ∑NDL-PCBs to 1.55 (95% CI: 1.01, 2.38) for HCB (p < 0.05 only for HCB), and cross-sectional ORs ranged 1.62 (95% CI: 1.13; 2.32) for p,p'-DDE to 2.06 (95% CI: 1.29, 3.28) for ∑DL-PCBs (p < 0.05 for all POPs). In analyses of non-diabetic individuals, higher baseline BMI, decreased weight and decreased plasma lipid concentrations were associated with a slower decrease of POPs. Cases had, besides a higher BMI, reduced cholesterol and weight gain at follow-up compared to controls, which can explain the higher ORs in the cross-sectional assessments. DISCUSSION:The association between POPs and T2D was confirmed, but an indication that individuals body fat history might influence POP-T2D associations weakens the epidemiological support for a causal association. It also warrants studies based on other exposure metrics than biomonitoring. In addition, we note that a cross-sectional design overestimates the ORs if T2D cases have successfully intervened on weight and/or blood lipids, as changes in these factors cause changes in POPs.
journal_name
Environ Resjournal_title
Environmental researchauthors
Tornevi A,Sommar J,Rantakokko P,Åkesson A,Donat-Vargas C,Kiviranta H,Rolandsson O,Rylander L,Wennberg M,Bergdahl IAdoi
10.1016/j.envres.2019.04.017subject
Has Abstractpub_date
2019-07-01 00:00:00pages
35-45eissn
0013-9351issn
1096-0953pii
S0013-9351(19)30226-9journal_volume
174pub_type
杂志文章abstract:BACKGROUND:Exposure to traffic pollution has been linked to numerous adverse health endpoints. Despite this, limited data examining traffic exposures during realistic commutes and acute response exists. OBJECTIVES:We conducted the Atlanta Commuters Exposures (ACE-1) Study, an extensive panel-based exposure and health ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2014.05.004
更新日期:2014-08-01 00:00:00
abstract::Ten years after the Aznalcóllar mine spill, the decline in metal contamination in the area is evident. However, some elements are still found in elevated concentrations. In Scrobicularia plana, zinc, lead, and arsenic exceeded health advisory levels at several locations although there is no indication of risks associa...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2011.07.011
更新日期:2011-11-01 00:00:00
abstract::This paper reports the effects of exposure to static, sinusoidal (50 Hz), and combined static/sinusoidal magnetic fields on cultured astroglial cells. Confluent primary cultures of astroglial cells were exposed to a 1-mT sinusoidal, static, or combined magnetic field for 1h. In another experiment, cells were exposed t...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2004.12.010
更新日期:2005-07-01 00:00:00
abstract::There is mounting evidence that maternal exposure to ambient air pollution during pregnancy is associated with adverse birth outcomes. We examined birth weight and small for gestational age (SGA <10th percentile for age and gender) among 26,617 singleton full-term births in Brisbane, Australia (July 2000-June 2003), i...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2006.06.010
更新日期:2007-03-01 00:00:00
abstract::Air pollution caused by particulate matter (PM) has become a serious issue, and significant research has focused on managing large stationary emission sources, i.e., the primary sources of PM. Currently, the U.S. Environmental Protection Agency (EPA) Method 201A and ISO 23210 are predominantly employed to measure the ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110507
更新日期:2021-02-01 00:00:00
abstract::Blood lead (PbB) and hemoglobin levels (Hb) were determined in 40 battery repair/recycling shop workers, 16 radiator repair shop workers, and 20 children living in the immediate vicinity of these shops. Unexposed residents with similar socioeconomic status were also investigated. Mean PbB level was significantly highe...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1999.4024
更新日期:2000-03-01 00:00:00
abstract::Continuous air quality monitoring in the Vojvodina district of Serbia and Montenegro has shown high levels of Cd, especially in the outskirts of large towns such as Kikinda. The construction and metal processing industries located in Kikinda have been emitting significant amounts of heavy metals into the environment. ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2004.05.008
更新日期:2005-01-01 00:00:00
abstract::Variation in individual susceptibility to arsenic-induced disease may be partially explained by genetic differences in arsenic metabolism. Mounting epidemiological evidence and in vitro studies suggest that methylated arsenic metabolites, particularly monomethylarsonic (MMA3), are more acutely toxic than inorganic ars...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2010.05.001
更新日期:2010-08-01 00:00:00
abstract::Commercial and sport-caught fish provide a healthy source of dietary protein, omega-3 fatty acids, and other micronutrients. Regular fish consumption has been associated with decreased risk of heart disease and health professionals encourage adults to include fish in their weekly diets. However, fish harvested from co...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2009.09.008
更新日期:2010-01-01 00:00:00
abstract::The objective of this short paper is to call upon the scientific community to channel its attention to the duty and heedfulness of social justice issues. While recognized for decades the impact of social injustice on public health and its disproportionate effects on poorer communities, little has been done to systemat...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110675
更新日期:2020-12-26 00:00:00
abstract::Despite intense societal and scientific debates regarding glyphosate toxicity, it remains the most widely used herbicide. The primary metabolite of glyphosate, AMPA (aminomethylphosphonic acid), is the main contaminant detected in surface waters worldwide, both because of the extensive use of glyphosate and because of...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109944
更新日期:2020-11-01 00:00:00
abstract::There is growing evidence that exposure to persistent organic pollutants (POPs) is statistically associated with incidence of cardiovascular disease (CVD) or its risk factors. Decarbromodiphenyl ether (BDE-209) is a new POP which exists extensively in human tissues, but its potential effects on CVD have so far receive...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2018.10.035
更新日期:2019-02-01 00:00:00
abstract::In this study, the bioavailability of DDTr (sum of DDT, DDD and DDE isomers) in pesticide-contaminated soil was assessed using an in vivo mouse model. DDTr relative bioavailability (RBA) ranged from 18.7±0.9 (As35) to 60.8±7.8% (As36) indicating that a significant portion of soil-bound DDTr was not available for absor...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2016.06.039
更新日期:2016-10-01 00:00:00
abstract::Traditional food consumption for Indigenous peoples is associated with improved nutrition and health but can also pose potential risks via exposure to contaminants. Polycyclic aromatic hydrocarbons (PAHs) are compounds of interest due to their widespread presence (e.g., their metabolites are detected in up to 100% of ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.109112
更新日期:2020-03-01 00:00:00
abstract::Pesticides, despite their known toxicity, are widely used in developing countries. Evaluating the pattern of their use would be interesting to assess the appropriateness of adequate intervention. Using a standardized questionnaire, a knowledge, attitude, and practice study was performed in two Lebanese regions, in whi...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/s0013-9351(03)00092-6
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Genetic and environmental factors have been recognized to play an important role in autism. The possibility that exposure to outdoor air pollution increases the risk of autism spectrum disorder (ASD) has been an emerging area of research. Herein, we present a systematic review, and meta-analysi...
journal_title:Environmental research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.envres.2016.07.030
更新日期:2016-11-01 00:00:00
abstract::Marine pollution gives rise to concern not only about the environment itself but also about the impact on food safety and consequently on public health. European authorities and consumers have therefore become increasingly worried about the transfer of contaminants from the marine environment to seafood. So-called "co...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2015.06.011
更新日期:2015-11-01 00:00:00
abstract::This study evaluated the variation over a year in airborne endotoxin levels in the indoor environment of five university laboratories in Seoul, South Korea, and examined the micro-environmental factors that influenced endotoxin levels. These included temperature, relative humidity, CO2, CO, illumination, and wind velo...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2015.11.025
更新日期:2016-02-01 00:00:00
abstract::There is interest in determining the relationship between fine particulate matter air pollution and various health outcomes, including birth outcomes such as term low birth weight. Previous studies have come to different conclusions. In this study we consider whether the effect may vary by location and gestational per...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2014.05.034
更新日期:2014-10-01 00:00:00
abstract::Increasing the number of applications of rare earth elements (REEs) has led to increased release of these metals into the environment. Removal of REEs from e-wastes is very important considering the increasing demand for these elements, the limited resource availability of them as well as the significant environmental...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110171
更新日期:2020-12-01 00:00:00
abstract::Environmental exposure to manganese (Mn) results in several toxic effects, mainly neurotoxicity. This study investigated associations among Mn exposure, neuropsychological performance, biomarkers of oxidative damage and early kidney dysfunction in children aged 6-12 years old. Sixty-three children were enrolled in thi...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2016.01.035
更新日期:2016-05-01 00:00:00
abstract::This paper examines the reliability of sport fish consumption data from the New York State Angler Cohort Study (NYSACS). NYSACS is a prospective cohort study conducted among New York State registered sportsmen and fishermen. Sport fish consumption information for New York State waters including the Great Lakes between...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2004.01.010
更新日期:2005-02-01 00:00:00
abstract::Paraquat is known to produce hyperglycemia in rodents, although the mechanisms responsible for the hyperglycemic effect of paraquat are not clearly understood. In this study we report the effects of paraquat (25 mg/kg iv) on plasma glucose, cortisol, catecholamines, and insulin in dogs. Paraquat caused a significant i...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/0013-9351(83)90169-x
更新日期:1983-02-01 00:00:00
abstract::Adult male inbred Wistar rats were given a subtoxic dose of cadmium (25 ppm) orally for 4 weeks prior to and during immunization with sheep erythrocytes (E). The control group received tap water during the experimental period. No difference in the antibody response to E was found between the two groups. Mononuclear pe...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/0013-9351(83)90019-1
更新日期:1983-08-01 00:00:00
abstract::This research aims to explore patterns of accumulation of a mixture of 15 Persistent Toxic Substances (PTS) in the adipose tissue of 227 individuals of an adult cohort from Granada Province (Southern Spain). Information about residence and occupation during participants lifetime was gathered by means of validated ques...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110687
更新日期:2020-12-29 00:00:00
abstract::In this paper, a comparative study on removal of the emerging pollutant phenazone (PNZ) by two treatment processes UVA/Fe(II)/persulfate (PS) and UVA/Fe(II)/peroxymonosulfate (PMS) was conducted. The two processes showed high efficiency in PNZ degradation, followed by a reasonable mineralization. The treatment system ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110054
更新日期:2020-12-01 00:00:00
abstract::A novel method to enhance sludge dewaterability with ammonium sulfate ((NH4)2SO4) was proposed, and the potential reuse of dewatered sludge cake and filtrate as nitrogen fertilizers was evaluated. Compared with raw sludge, 87.91% reduction of capillary suction time (CST) and 88.02% reduction of specific resistance to ...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2020.110050
更新日期:2020-12-01 00:00:00
abstract::The influence of anthropogenic pollution, particularly with polycyclic aromatic hydrocarbons (PAHs) on soil toxicity and spread of antibiotic resistance genes (ARGs) is extremely important nowadays. We studied 20 soil samples from a technogenically polluted site, municipal solid wastes (MSW) landfills, and rural settl...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2021.110715
更新日期:2021-01-11 00:00:00
abstract:BACKGROUND:Low-income communities and communities of color have been shown to experience disproportionate exposure to agricultural pesticides, which have been linked to poorer neurobehavioral outcomes in infants and children. Few studies have assessed health impacts of pesticide mixtures in the context of socioeconomic...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1016/j.envres.2016.05.048
更新日期:2016-10-01 00:00:00
abstract::Lactating female members and spouses of male members of the New York State Angler Cohort who agreed to provide breast milk samples were the subjects of this study. Questionnaires were provided to participants focusing on Lake Ontario fish consumption, reproductive history, and lactation history. Milk samples were anal...
journal_title:Environmental research
pub_type: 杂志文章
doi:10.1006/enrs.1998.3939
更新日期:1999-02-01 00:00:00