Abstract:
BACKGROUND:Artemisinin-based combination therapy (ACT) is the global standard of care for uncomplicated falciparum malaria. First reports of ACT resistance came from western Cambodia and the Thailand-Cambodia border in 2002-2004. The subsequent emergence and expansion of Plasmodium falciparum strains resistant to the artemisinin component and ACT are now threatening the efficacy of falciparum malaria treatment. METHODS:We performed a literature review on the history and the current degree of geographic expansion of artemisinin and ACT resistance. Resistance against artemisinins is defined as >5% of patients carrying PfKelch13 (K13) mutations, all of whom have been found to have persistent parasitaemia by microscopy on Day 3 after treatment. RESULTS:Several studies including the multi-centre Tracking Resistance to Artemisinin Collaboration study investigated artemisinin resistance in Southeast Asia and beyond and demonstrated increasing prevalence of P. falciparum infections with slow parasite clearance rates in the Greater Mekong Subregion (GMS). K13 mutations were strongly associated with delayed P. falciparum parasite clearance, and the prevalence of the mutation PfKelch13 C580Y is increasing in the GMS. Resistance to ACT regimens is now well established in western Cambodia and in eastern Thailand, southern Laos and southern Vietnam. Moreover, the prevalence of slow P. falciparum parasite clearance has continuously increased over the past 10-15 years at the Thailand-Myanmar border, in nearly all regions of Myanmar, and at the Myanmar-China border. CONCLUSION:Multidrug resistant malaria is a rapidly increasing problem, but fortunately still limited to Southeast Asia, in particular to the GMS. In the long-term it may threaten global progress in malaria control but is not yet of concern with regards to malaria prophylaxis, as ACTs are not used for prevention in travellers, current ACT regimens are still effective in most malaria endemic areas outside the GMS and the preferred travellers' prophylaxis atovaquone-proguanil and doxycycline remain protective. However, artemsinin resistance in the GMS is of real concern to travellers as it will affect the choice of malaria treatment including standby-emergence treatment.
journal_name
J Travel Medjournal_title
Journal of travel medicineauthors
Müller O,Lu GY,von Seidlein Ldoi
10.1093/jtm/taz030subject
Has Abstractpub_date
2019-06-01 00:00:00issue
4eissn
1195-1982issn
1708-8305pii
5475008journal_volume
26pub_type
杂志文章,评审abstract::Acute eosinophilic pneumonia (AEP) has been reported following chloroquine or mefloquine exposure, both structurally related to piperaquine. We report a case of AEP with typical CT scan patterns, hypereosinophilia in blood (9.8 109/l), and bronchoalveolar lavage (78% of 600 000 cells/ml), 10 days after artenimol-piper...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1093/jtm/tax023
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Imported measles cases and outbreaks involving Japanese travelers have been reported from the United States and other countries. For the United States, Japan is the top country of origin. The aims of this study were to analyze measles exportation trends from Japan to the United States and to suggest recommen...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2008.00183.x
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:Scarce data are available on the occurrence of ailments and diseases in children during travel. We studied the characteristics and frequencies of ailments in children aged 0 to 18 years and their parents during traveling. METHODS:A prospective observational study on ailments reported by children and parents ...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2011.00551.x
更新日期:2012-05-01 00:00:00
abstract::Shigella bacteremias are uncommon in immune-competent adults. We report two cases of Shigella flexneri bacteremia that occurred in healthy young travelers, who recovered. Self-medication with loperamide and ibuprofen without antibiotics (case 1) and concomitant falciparum malaria (case 2) were the only co-morbidities ...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2012.00627.x
更新日期:2012-07-01 00:00:00
abstract::Travellers visiting friends and relatives (VFRs) often have complex pre-travel needs. We identified the characteristics, destinations, vaccinations and pre-travel advice provided to VFRs and compared these with non-VFR travellers. The significant differences we found suggest that future research should focus on improv...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1093/jtm/tax038
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:The effectiveness of preventive measures in combating travel-related illnesses is well recognized. However, there is a lack of information on the economic value of any travel-associated preventive measures in the literature. OBJECTIVES:The purpose of this article is to report the values of willingness to pa...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.2310/7060.2005.12202
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the tolerance and immunogenicity of a hepatitis A vaccine using immunopotentiating reconstituted influenza virosomes (IRIV) as adjuvant when administered simultaneously with a yellow fever vaccine (YFV). METHOD:An open prospective trial with two parallel groups was ...
journal_title:Journal of travel medicine
pub_type: 临床试验,杂志文章
doi:10.1111/j.1708-8305.1999.tb00523.x
更新日期:1999-12-01 00:00:00
abstract::Infectious mononucleosis (IM), resulting from Epstein-Barr virus (EBV) infection, and IM-like syndromes, mainly due to cytomegalovirus (CMV), Toxoplasma gondii, or human immunodeficiency virus (HIV), have been occasionally reported in travelers returning from the tropics. Our objective was to investigate the prevalenc...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2006.00049.x
更新日期:2006-07-01 00:00:00
abstract:AIM:International travel has become popular among young adults. This study evaluated the rate and characteristics of travel-associated health risks among young adults with type 1 diabetes mellitus (T1DM) compared with healthy same-aged individuals. METHODS:A retrospective study was conducted of 47 young adults with T1...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/jtm.12136
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Dengue, a mosquito-transmitted viral disease, is a risk for visitors in tropical and subtropical areas. Several participants in a community-assistance program in Tortola, British Virgin Islands, in August, 1995, reported dengue-like symptoms either before or soon after leaving the island. METHODS:We conduct...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.2310/7060.2000.00022
更新日期:2000-03-01 00:00:00
abstract::Incidence of malaria is increasing in travelers and soldiers. In 2006, a survey was performed in a French battalion returning from a malaria-endemic area. According to the chemoprophylaxis plasma concentration and the individuals' reports, the noncompliance rates were high, respectively, 63.4 and 54.7%. ...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2008.00219.x
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:International migrants represent only 4.5% of the world's population, but they may become a challenge for host countries. The aim of the study was to assess the impact of this population on health parameters in Como county, on the northern border of Italy. METHODS:A retrospective analysis of migrants' admis...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.2310/7060.2000.00082
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVE:To assess the awareness of the mode of rabies transmission, travel-associated rabies risk, and adequate preventive measures among French travelers. METHODS:Three hundred travelers were administered a detailed questionnaire prior to pretravel advice, addressing their knowledge, attitudes, and practices (KAP) ...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2008.00283.x
更新日期:2009-03-01 00:00:00
abstract::Background: In recent years, several hepatitis A vaccines have been developed. We wished to evaluate the safety, reactogenicity, and immunogenicity of an inactivated hepatitis A vaccine, containing 1440 EI.U., and to monitor the kinetics of the antibodies monthly for the first year after administration of a single dos...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.1996.tb00711.x
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:The prevalence of motion sickness approaches 100% on rough seas. Some previous studies have reported a strong association between location on a ship and the risk of motion sickness, whereas other studies found no association. This study was undertaken to determine if there is a statistical association betwee...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.2310/7060.2000.00042
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Adventure trips to Africa have become more frequent, and rafting on some of the great rivers has become almost commonplace. We describe three rafting trips on the Omo River in Ethiopia, after which most of the participants were diagnosed with schistosomiasis. METHODS:After index cases from the three groups ...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.2310/7060.2005.00002
更新日期:2005-01-01 00:00:00
abstract::Retrospective studies have shown that the first HIV positive patient in the Federal Republic (FR) of Yugoslavia (Serbia and Montenegro) was detected among intravenous drug users (IDUs) in 1981. The first two cases of AIDS in Yugoslavia were registered in 19851; one of them was infected in subSaharan Africa. The object...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.1996.tb00736.x
更新日期:1996-09-01 00:00:00
abstract::Zika and Ebola viruses can persist in semen and pose a risk for sexual transmission. To determine if dengue virus, another flavivirus, is similarly detectable in semen, we performed dengue PCR on semen in five patients with acute dengue virus infection. All five tested negative, suggesting that dengue does not pose a ...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1093/jtm/tay023
更新日期:2018-01-01 00:00:00
abstract::In a marine envenomation, identification of the culprit organism can be difficult. In this case report, we present our method to identify snakelocks anemone (Anemonia viridis or formerly Anemonia sulcata) as the culprit of a severe toxic skin reaction. A. viridis is one of the most common anemones of the Mediterranean...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/jtm.12223
更新日期:2015-07-01 00:00:00
abstract::A 35-year-old healthy Dutch woman went on a trek (Lang Tang) in Nepal up to an approximate altitude of about 3800 meters. She had no prior history of any medical problems except attacks of generalized epilepsy when she was 19 years old, which had been controlled with antiepileptic medications. She had had no attacks a...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.1998.tb00512.x
更新日期:1998-12-01 00:00:00
abstract::Acute rheumatic fever presenting as fever in a returned traveler has not previously been described. We report one such case. ...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.2310/7060.2005.12611
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:Medical emergencies often occur on commercial airline flights, but valid data on their causes and consequences are rare. Therefore, it is unclear what emergency medical equipment is necessary. Although a minimum standard for medical equipment is defined in regulations, additional material is not standardized...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/jtm.12138
更新日期:2014-09-01 00:00:00
abstract::Increasing population mobility and increasing frequency and variety of sexually transmitted infections (STI) are closely linked around the globe. Although all mobile populations are at increased risk for acquiring STIs, international travelers are the focus of this review. Several aspects of travel such as opportunity...
journal_title:Journal of travel medicine
pub_type: 杂志文章,评审
doi:10.1111/j.1708-8305.2006.00061.x
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Millions of Americans visit developing countries each year, however, little is known about their health during travel. This study describes health problems in a large cohort of American travelers during and after their trip. METHODS:A 2-year survey of 784 travelers (95% follow-up) was conducted for persons ...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.2310/7060.2000.00075
更新日期:2000-09-01 00:00:00
abstract::Canadians are increasingly travelling to areas that would necessitate a pre-travel consultation. Changes in professional regulations in Canada allow greater autonomy of nurses and pharmacists, resulting in shifts in provision of travel health services. We surveyed 824 Canadian travel clinics, 270 (33%) of whom respond...
journal_title:Journal of travel medicine
pub_type: 社论,评审
doi:10.1093/jtm/tay032
更新日期:2018-05-01 00:00:00
abstract::Mass gathering is well known to concentrate and amplify the transmission of infectious respiratory diseases. Here we report a possible case of coinfection with influenza A/H1N1 and varicella in a young French traveler returning from a rock festival in Hungary. We report a cluster of influenza A/H1N1 cases at this fest...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2010.00410.x
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Health-care professionals can help travelers by providing accurate pre-travel counseling for mosquito-transmitted diseases such as malaria, yellow fever, and dengue fever. Governments and international organizations will benefit from knowledge survey among health professionals in this field to promote the de...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2010.00483.x
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Several live attenuated vaccines against bacterial enteric pathogens have recently been licensed. These include the Salmonella typhi Ty21a typhoid vaccine (Vivotif Berna(R) Vaccine) and Vibrio cholerae CVD103-HgR cholera vaccine (Mutacol Berna(R) Vaccine). They comprise a unique class of biologics in which p...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.1998.tb00449.x
更新日期:1998-03-01 00:00:00
abstract::Scrub typhus should be considered in any febrile patient presenting with a macular rash, a polyadenopathy, an eschar, or a history of environmental exposure in endemic areas. The differential diagnosis includes malaria, typhoid fever, leptospirosis, and arboviroses. Doxycycline 100 mg twice daily for 7 days should be ...
journal_title:Journal of travel medicine
pub_type: 杂志文章,评审
doi:10.1111/j.1708-8305.2007.00151.x
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Travel-related shigellosis is not well documented in Canada although it is frequently acquired abroad and can cause severe disease. OBJECTIVES:To describe the epidemiology of travel-related cases of shigellosis for Quebec (Canada) and to identify high-risk groups of travelers. METHOD AND DATA SOURCES:We pe...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/jtm.12130
更新日期:2014-09-01 00:00:00