Adenomatoid mesothelioma with intranuclear inclusion bodies: a case report with cytological and histological findings.

Abstract:

:We report a very unusual cytologic feature, intranuclear inclusion bodies, in mesothelioma of a predominantly adenomatoid type. The patient, a 57-year-old woman, was presented with dyspnea and right pleural effusion. Pleural aspiration cytology revealed many cohesive ball-like clusters, with a tubular pattern, composed of small atypical cells displaying a high-nuclear-cytoplasmic ratio. They had a nuclear groove and irregular intranuclear inclusion bodies. Right lung partial resection with thoracoscopy revealed that a white tumor had proliferated along the pleural surface at S(8) . Histology revealed nodular tumor cells forming dilated structures mixed with small tubular or glandular structures similar to those seen in benign adenomatoid tumors. These tumor cells had invaded peripheral lung tissues. Such inclusion bodies have not been reported earlier in mesothelioma. On the basis of this observation, we propose that the adenomatoid type of malignant mesothelioma be added to the differential diagnosis of malignant effusions when tumor cells with nuclear grooves and intranuclear inclusions are found in pleural aspiration cytology.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Kawai T,Kawashima K,Serizawa H,Miura H,Kyeongil K

doi

10.1002/dc.22932

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

436-40

issue

5

eissn

8755-1039

issn

1097-0339

journal_volume

42

pub_type

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