Differences in Neuropathogenesis of Encephalitic California Serogroup Viruses.

Abstract:

:The California serogroup of orthobunyaviruses comprises a group of mosquitoborne viruses, including La Crosse (LACV), snowshoe hare (SSHV), Tahyna (TAHV), Jamestown Canyon (JCV), and Inkoo (INKV) viruses, that cause neurologic disease in humans of differing ages with varying incidences. To determine how the pathogenesis of these viruses differs, we compared their ability to induce disease in mice and replicate and induce cell death in vitro. In mice, LACV, TAHV, and SSHV induced neurologic disease after intraperitoneal and intranasal inoculation, and JCV induced disease only after intranasal inoculation. INKV rarely induced disease, which correlated with less viral antigen in the brain than the other viruses. In vitro, all viruses replicated to high titers; however, LACV, SSHV, and TAHV induced high cell death, whereas JCV and INKV did not. Results demonstrated that CSG viruses differ in neuropathogenesis in vitro and in vivo, which correlates with the differences in pathogenesis reported in humans.

journal_name

Emerg Infect Dis

authors

Evans AB,Winkler CW,Peterson KE

doi

10.3201/eid2504.181016

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

728-738

issue

4

eissn

1080-6040

issn

1080-6059

journal_volume

25

pub_type

杂志文章
  • Hepatitis E virus genotype 3 in humans and Swine, Bolivia.

    abstract::We determined the seroprevalence of hepatitis E virus (HEV) in persons in 2 rural communities in southeastern Bolivia and the presence of HEV in human and swine fecal samples. HEV seroprevalence was 6.3%, and HEV genotype 3 strains with high sequence homology were detected. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1708.100769

    authors: Dell'Amico MC,Cavallo A,Gonzales JL,Bonelli SI,Valda Y,Pieri A,Segund H,Ibañez R,Mantella A,Bartalesi F,Tolari F,Bartoloni A

    更新日期:2011-08-01 00:00:00

  • Syndromic surveillance in public health practice, New York City.

    abstract::The New York City Department of Health and Mental Hygiene has established a syndromic surveillance system that monitors emergency department visits to detect disease outbreaks early. Routinely collected chief complaint information is transmitted electronically to the health department daily and analyzed for temporal a...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1005.030646

    authors: Heffernan R,Mostashari F,Das D,Karpati A,Kulldorff M,Weiss D

    更新日期:2004-05-01 00:00:00

  • Human rickettsialpox, southeastern Mexico.

    abstract::The detection of Rickettsia akari in 2 human patients increased the diversity of rickettsioses affecting the public health in the southeast of Mexico. Rickettsialpox should be considered in the differential diagnosis with other febrile illnesses for the correct diagnosis and accurate treatment of this potential threat...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1510.081507

    authors: Zavala-Castro JE,Zavala-Velázquez JE,Peniche-Lara GF,Sulú Uicab JE

    更新日期:2009-10-01 00:00:00

  • Detection of SARS coronavirus in patients with suspected SARS.

    abstract::Cases of severe acute respiratory syndrome (SARS) were investigated for SARS coronavirus (SARS-CoV) through RNA tests, serologic response, and viral culture. Of 537 specimens from patients in whom SARS was clinically diagnosed, 332 (60%) had SARS-CoV RNA in one or more clinical specimens, compared with 1 (0.3%) of 332...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1002.030610

    authors: Chan KH,Poon LL,Cheng VC,Guan Y,Hung IF,Kong J,Yam LY,Seto WH,Yuen KY,Peiris JS

    更新日期:2004-02-01 00:00:00

  • Characterization and Source Investigation of Multidrug-Resistant Salmonella Anatum from a Sustained Outbreak, Taiwan.

    abstract::An ongoing outbreak of multidrug-resistant Salmonella enterica serovar Anatum began in Taiwan in 2015. Pork and poultry were identified as vehicles for transmission. Contaminated meat contributed to the high rate of infections among children. Nearly identical Salmonella Anatum strains have been identified in the Unite...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2612.200147

    authors: Feng Y,Chang YJ,Pan SC,Su LH,Li HC,Yang HP,Yu MJ,Chiu CH

    更新日期:2020-12-01 00:00:00

  • Ribavirin for Chronic Hepatitis Prevention among Patients with Hematologic Malignancies.

    abstract::Findings among a cohort of 26 patients who had hematologic malignancies and hepatitis E virus (HEV) infection support that HEV can induce chronic hepatitis. However, a 3-month course of ribavirin can induce a rapid viral clearance, reducing the risk for chronic hepatitis and enabling continuation of cytotoxic treatmen...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2108.150199

    authors: Tavitian S,Peron JM,Huguet F,Kamar N,Abravanel F,Beyne-Rauzy O,Oberic L,Faguer S,Alric L,Roussel M,Gaudin C,Ysebaert L,Huynh A,Recher C

    更新日期:2015-08-01 00:00:00

  • International Salmonella Typhimurium DT104 infections, 1992-2001.

    abstract::The incidence of multidrug-resistant (MDR) Salmonella Typhimurium infections in humans, and in particular MDR definitive phage type 104 (DT104), has increased substantially in many countries in the last 2 decades, often associated with increased illness. To examine the magnitude of this problem, a survey was conducted...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1106.041017

    authors: Helms M,Ethelberg S,Mølbak K,DT104 Study Group.

    更新日期:2005-06-01 00:00:00

  • Need for BCG Vaccination to Prevent TB in High-Incidence Countries and Populations.

    abstract::An estimated one quarter of persons worldwide are infected with Mycobacterium tuberculosis. In 2018, the World Health Organization issued revised guidance on BCG vaccine for high-risk groups. The World Health Organization should consider guiding countries on a case-by-case basis in developing appropriate BCG policies ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2603.191232

    authors: Pooransingh S,Sakhamuri S

    更新日期:2020-03-01 00:00:00

  • Ocular vaccinia infection in laboratory worker, Philadelphia, 2004.

    abstract::We report a case of ocular vaccinia infection in an unvaccinated laboratory worker. The patient was infected by a unique strain used in an experiment performed partly outside a biosafety cabinet. Vaccination should continue to be recommended, but laboratories with unvaccinated workers should also implement more string...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1201.051126

    authors: Lewis FM,Chernak E,Goldman E,Li Y,Karem K,Damon IK,Henkel R,Newbern EC,Ross P,Johnson CC

    更新日期:2006-01-01 00:00:00

  • Clusters of multidrug-resistant Mycobacterium tuberculosis cases, Europe.

    abstract::Molecular surveillance of multidrug-resistant tuberculosis (MDR TB) was implemented in Europe as case reporting in 2005. For all new MDR TB cases detected from January 2003 through June 2007, countries reported case-based epidemiologic data and DNA fingerprint patterns of MDR TB strains when available. International c...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1507.080994

    authors: Devaux I,Kremer K,Heersma H,Van Soolingen D

    更新日期:2009-07-01 00:00:00

  • Melioidosis: an emerging infection in Taiwan?

    abstract::From January 1982 to May 2000, 17 infections caused by Burkholderia pseudomallei were diagnosed in 15 patients in Taiwan; almost all the infections were diagnosed from 1994 to May 2000. Of the 15 patients, 9 (60%) had underlying diseases, and 10 (67%) had bacteremic pneumonia. Thirteen (76%) episodes of infection were...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0703.010310

    authors: Hsueh PR,Teng LJ,Lee LN,Yu CJ,Yang PC,Ho SW,Luh KT

    更新日期:2001-05-01 00:00:00

  • Reassortant Avian Influenza A(H9N2) viruses in chickens in retail poultry shops, Pakistan, 2009-2010.

    abstract::Phylogenetic analysis of influenza viruses collected during December 2009-February 2010 from chickens in live poultry retail shops in Lahore, Pakistan, showed influenza A(H9N2) lineage polymerase and nonstructural genes generate through inter- and intrasubtypic reassortments. Many amino acid signatures observed were c...

    journal_title:Emerging infectious diseases

    pub_type: 历史文章,杂志文章

    doi:10.3201/eid2104.141570

    authors: Chaudhry M,Angot A,Rashid HB,Cattoli G,Hussain M,Trovò G,Drago A,Valastro V,Thrusfield M,Welburn S,Eisler MC,Capua I

    更新日期:2015-04-01 00:00:00

  • Serologic Evidence of Severe Fever with Thrombocytopenia Syndrome Virus and Related Viruses in Pakistan.

    abstract::We describe the seroprevalence of severe fever with thrombocytopenia syndrome virus (SFTSV) and the association of antibody occurrence with location, sex, and age among the human population in Pakistan. Our results indicate substantial activity of SFTSV and SFTSV-related viruses in this country. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2607.190611

    authors: Zohaib A,Zhang J,Saqib M,Athar MA,Hussain MH,Chen J,Sial AU,Tayyab MH,Batool M,Khan S,Luo Y,Waruhiu C,Taj Z,Hayder Z,Ahmed R,Siddique AB,Yang X,Qureshi MA,Ujjan IU,Lail A,Khan I,Sajjad-Ur-Rahman.,Zhang T,Den

    更新日期:2020-07-01 00:00:00

  • Pharmacologic Treatments and Supportive Care for Middle East Respiratory Syndrome.

    abstract::Available animal and cell line models have suggested that specific therapeutics might be effective in treating Middle East respiratory syndrome (MERS). We conducted a systematic review of evidence for treatment with pharmacologic and supportive therapies. We developed a protocol and searched 5 databases for studies de...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2606.200037

    authors: Kain T,Lindsay PJ,Adhikari NKJ,Arabi YM,Van Kerkhove MD,Fowler RA

    更新日期:2020-06-01 00:00:00

  • Possible interruption of malaria transmission, highland Kenya, 2007-2008.

    abstract::Highland areas where malaria transmission is unstable are targets for malaria elimination because transmission decreases to low levels during the dry season. In highland areas of Kipsamoite and Kapsisiywa, Kenya (population approximately 7,400 persons), annual household indoor residual spraying with a synthetic pyreth...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1512.090627

    authors: John CC,Riedesel MA,Magak NG,Lindblade KA,Menge DM,Hodges JS,Vulule JM,Akhwale W

    更新日期:2009-12-01 00:00:00

  • Chikungunya virus, southeastern France.

    abstract::In September 2010, autochthonous transmission of chikungunya virus was recorded in southeastern France, where the Aedes albopictus mosquito vector is present. Sequence analysis of the viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the virus in Euro...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1705.101873

    authors: Grandadam M,Caro V,Plumet S,Thiberge JM,Souarès Y,Failloux AB,Tolou HJ,Budelot M,Cosserat D,Leparc-Goffart I,Desprès P

    更新日期:2011-05-01 00:00:00

  • Sympatric occurrence of 3 arenaviruses, Tanzania.

    abstract::To determine the specificity of Morogoro virus for its reservoir host, we studied its host range and genetic diversity in Tanzania. We found that 2 rodent species other than Mastomys natalensis mice carry arenaviruses. Analysis of 340 nt of the viral RNA polymerase gene showed sympatric occurrence of 3 distinct arenav...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1604.091721

    authors: de Bellocq JG,Borremans B,Katakweba A,Makundi R,Baird SJ,Becker-Ziaja B,Günther S,Leirs H

    更新日期:2010-04-01 00:00:00

  • Delinquent mortgages, neglected swimming pools, and West Nile virus, California.

    abstract::Adjustable rate mortgages and the downturn in the California housing market caused a 300% increase in notices of delinquency in Bakersfield, Kern County. This led to large numbers of neglected swimming pools, which were associated with a 276% increase in the number of human West Nile virus cases during the summer of 2...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1411.080719

    authors: Reisen WK,Takahashi RM,Carroll BD,Quiring R

    更新日期:2008-11-01 00:00:00

  • Scarlet fever epidemic, Hong Kong, 2011.

    abstract::More than 900 cases of scarlet fever were recorded in Hong Kong during January-July, 2011. Six cases were complicated by toxic shock syndrome, of which 2 were fatal. Pulsed-field gel electrophoresis patterns suggested a multiclonal epidemic; emm12 was the predominant circulating type. We recommend genetic testing of a...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1810.111900

    authors: Luk EY,Lo JY,Li AZ,Lau MC,Cheung TK,Wong AY,Wong MM,Wong CW,Chuang SK,Tsang T

    更新日期:2012-10-01 00:00:00

  • Primary amebic meningoencephalitis caused by Naegleria fowleri, Karachi, Pakistan.

    abstract::We report 13 cases of Naegleria fowleri primary amebic meningoencephalitis in persons in Karachi, Pakistan, who had no history of aquatic activities. Infection likely occurred through ablution with tap water. An increase in primary amebic meningoencephalitis cases may be attributed to rising temperatures, reduced leve...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1702.100442

    authors: Shakoor S,Beg MA,Mahmood SF,Bandea R,Sriram R,Noman F,Ali F,Visvesvara GS,Zafar A

    更新日期:2011-02-01 00:00:00

  • Distinguishing Japanese Spotted Fever and Scrub Typhus, Central Japan, 2004- 2015.

    abstract::Japanese spotted fever (JSF) and scrub typhus (ST) are endemic to Japan and share similar clinical features. To document the clinical and epidemiologic characteristics that distinguish these 2 rickettsial diseases, during 2004-2015 we recruited 31 JSF patients, 188 ST patients, and 97 nonrickettsial disease patients f...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.3201/eid2409.171436

    authors: Sando E,Suzuki M,Katoh S,Fujita H,Taira M,Yaegashi M,Ariyoshi K

    更新日期:2018-09-01 00:00:00

  • Cost-effectiveness of antiviral stockpiling and near-patient testing for potential influenza pandemic.

    abstract::A decision analytical model was developed to investigate the cost-effectiveness of stockpiling antiviral (AV) drugs for a potential influenza pandemic in the United Kingdom and the possible role of near-patient testing in conserving AV drug stocks. Under base-case assumptions (including a fixed stockpile that was smal...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1402.070478

    authors: Siddiqui MR,Edmunds WJ

    更新日期:2008-02-01 00:00:00

  • Hospital infection control in hematopoietic stem cell transplant recipients.

    abstract::Guidelines for Preventing Opportunistic Infections Among Hematopoietic Stem Cell Transplant Recipients contains a section on hospital infection control including evidence-based recommendations regarding ventilation, construction, equipment, plants, play areas and toys, health-care workers, visitors, patient skin and o...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章,评审

    doi:10.3201/eid0702.010223

    authors: Dykewicz CA

    更新日期:2001-03-01 00:00:00

  • Cryptosporidium muris, a rodent pathogen, recovered from a human in Perú.

    abstract::Cryptosporidium muris, predominantly a rodent species of Cryptosporidium, is not normally considered a human pathogen. Recently, isolated human infections have been reported from Indonesia, Thailand, France, and Kenya. We report the first case of C. muris in a human in the Western Hemisphere. This species may be an em...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0909.030047

    authors: Palmer CJ,Xiao L,Terashima A,Guerra H,Gotuzzo E,Saldías G,Bonilla JA,Zhou L,Lindquist A,Upton SJ

    更新日期:2003-09-01 00:00:00

  • Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant.

    abstract::All hepatitis E virus (HEV) variants reported to infect humans belong to the species Orthohepevirus A (HEV-A). The zoonotic potential of the species Orthohepevirus C (HEV-C), which circulates in rats and is highly divergent from HEV-A, is unknown. We report a liver transplant recipient with hepatitis caused by HEV-C i...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2412.180937

    authors: Sridhar S,Yip CCY,Wu S,Cai J,Zhang AJ,Leung KH,Chung TWH,Chan JFW,Chan WM,Teng JLL,Au-Yeung RKH,Cheng VCC,Chen H,Lau SKP,Woo PCY,Xia NS,Lo CM,Yuen KY

    更新日期:2018-12-01 00:00:00

  • Invasive disease caused by nontuberculous mycobacteria, Tanzania.

    abstract::Data on nontuberculous mycobacterial (NTM) disease in sub-Saharan Africa are limited. During 2006-2008, we identified 3 HIV-infected patients in northern Tanzania who had invasive NTM; 2 were infected with "Mycobacterium sherrisii" and 1 with M. avium complex sequevar MAC-D. Invasive NTM disease is present in HIV-infe...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1501.081093

    authors: Crump JA,van Ingen J,Morrissey AB,Boeree MJ,Mavura DR,Swai B,Thielman NM,Bartlett JA,Grossman H,Maro VP,van Soolingen D

    更新日期:2009-01-01 00:00:00

  • Detection of Dengue Virus among Children with Suspected Malaria, Accra, Ghana.

    abstract::We report new molecular evidence of locally acquired dengue virus infections in Ghana. We detected dengue viral RNA among children with suspected malaria by using a multipathogen real-time PCR. Subsequent sequence analysis revealed a close relationship with dengue virus serotype 2, which was implicated in a 2016 outbr...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2408.180341

    authors: Amoako N,Duodu S,Dennis FE,Bonney JHK,Asante KP,Ameh J,Mosi L,Hayashi T,Agbosu EE,Pratt D,Operario DJ,Fields B,Liu J,Houpt ER,Armah GE,Stoler J,Awandare GA

    更新日期:2018-08-01 00:00:00

  • Gram-positive rod surveillance for early anthrax detection.

    abstract::Connecticut established telephone-based gram-positive rod (GPR) reporting primarily to detect inhalational anthrax cases more quickly. From March to December 2003, annualized incidence of blood isolates was 21.3/100,000 persons; reports included 293 Corynebacterium spp., 193 Bacillus spp., 73 Clostridium spp., 26 Lact...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1109.041013

    authors: Begier EM,Barrett NL,Mshar PA,Johnson DG,Hadler JL,Connecticut Bioterrorism Field Epidemiology Response Team.

    更新日期:2005-09-01 00:00:00

  • Humans infected with relapsing fever spirochete Borrelia miyamotoi, Russia.

    abstract::Borrelia miyamotoi is distantly related to B. burgdorferi and transmitted by the same hard-body tick species. We report 46 cases of B. miyamotoi infection in humans and compare the frequency and clinical manifestations of this infection with those caused by B. garinii and B. burgdorferi infection. All 46 patients live...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1710.101474

    authors: Platonov AE,Karan LS,Kolyasnikova NM,Makhneva NA,Toporkova MG,Maleev VV,Fish D,Krause PJ

    更新日期:2011-10-01 00:00:00

  • SARS and pregnancy: a case report.

    abstract::We report a laboratory-confirmed case of severe acute respiratory syndrome (SARS) in a pregnant woman. Although the patient had respiratory failure, a healthy infant was subsequently delivered, and the mother is now well. There was no evidence of viral shedding at delivery. Antibodies to SARS virus were detected in co...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1002.030736

    authors: Robertson CA,Lowther SA,Birch T,Tan C,Sorhage F,Stockman L,McDonald C,Lingappa JR,Bresnitz E

    更新日期:2004-02-01 00:00:00