Abstract:
:Available animal and cell line models have suggested that specific therapeutics might be effective in treating Middle East respiratory syndrome (MERS). We conducted a systematic review of evidence for treatment with pharmacologic and supportive therapies. We developed a protocol and searched 5 databases for studies describing treatment of MERS and deaths in MERS patients. Risk of bias (RoB) was assessed by using ROBINS-I tool. We retrieved 3,660 unique citations; 20 observational studies met eligibility, and we studied 13 therapies. Most studies were at serious or critical RoB; no studies were at low RoB. One study, at moderate RoB, showed reduced mortality rates in severe MERS patients with extracorporeal membrane oxygenation; no other studies showed a significant lifesaving benefit to any treatment. The existing literature on treatments for MERS is observational and at moderate to critical RoB. Clinical trials are needed to guide treatment decisions.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Kain T,Lindsay PJ,Adhikari NKJ,Arabi YM,Van Kerkhove MD,Fowler RAdoi
10.3201/eid2606.200037subject
Has Abstractpub_date
2020-06-01 00:00:00pages
1102-1112issue
6eissn
1080-6040issn
1080-6059journal_volume
26pub_type
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