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Prospective long-term follow up of children with anorectal malformation: growth and development until 5years of age.

Abstract：

BACKGROUND/PURPOSE:To evaluate growth and development in children with anorectal malformations and to analyze effects of type of malformation and comorbidities. METHODS:Non-syndromal children with anorectal malformations were prospectively evaluated at 0.5, 1, 2, and 5 years. Biometrics were obtained at all visits. Mental and psychomotor function development was determined. RESULTS:108 children (59% male) were included. 49% had a high malformation, and 46% had ≥ 1 additional major comorbidity. All growth parameters were below the norm at all ages (p<0.01), irrespective of type of malformation. Children with ≥ 1 additional major anomaly had lower height at all ages; at 5 years, mean (95% CI) height was -1.83 (-2.7 to -1.1) and -0.70 (-1.3 to -0.1) in children with and without comorbidities, respectively (p=0.019). Mental development was normal, irrespective of the type of malformation or comorbidities. Motor development was delayed at all ages. At 5 years, motor development (n=30) was normal in 70%, borderline in 23%, and 7% had definitive motor problems (p=0.043). CONCLUSION:Non-syndromal children with anorectal malformations are at risk for growth impairment, especially those with additional major comorbidity. Mental development is normal. Motor development is slightly impaired. Supportive care should focus on growth, dietary management, and motor development besides defecation problems.

journal_name

J Pediatr Surg

journal_title

Journal of pediatric surgery

authors

van den Hondel D,Sloots CE,Gischler SJ,Meeussen CJ,Wijnen RM,IJsselstijn H,Surgical Long-term Follow Up team.

doi

10.1016/j.jpedsurg.2012.09.068

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

818-25

issue

4

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(12)00970-0

journal_volume

48

pub_type

杂志文章

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