当前位置： SCI文献检索 > JOURNAL OF PEDIATRIC SURGERY期刊下所有文献 > Prenatal retinoic acid up-regulates pulmonary gene expression of COUP-TFII, FOG2, and GATA4 in pulmonary hypoplasia.

Prenatal retinoic acid up-regulates pulmonary gene expression of COUP-TFII, FOG2, and GATA4 in pulmonary hypoplasia.

Abstract：

PURPOSE:Retinoids play an important role in lung development. Recently, prenatal treatment with retinoic acid (RA) has been reported to stimulate alveologenesis in hypoplastic lungs in the nitrofen model of congenital diaphragmatic hernia (CDH). Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) is a transcription factor in the steroid/thyroid hormone receptor superfamily, and targeted ablation of COUP-TFII causes CDH and associated lung hypoplasia in mice. Friend of GATA 2 (FOG2) is a zinc finger-containing protein that modulates the transcriptional activity of GATA proteins. GATA4 is a member of a family of DNA-binding proteins, which is found in the promoter regions of many genes. The COUP-TFII, FOG2, and GATA4 genes, regulated by the retinoid signaling pathway, are located on chromosomes 15q26, 8q23, and 8p23.1 respectively, regions reported to be deleted in individuals with CDH. The aim of this study was to examine the pulmonary gene expression of COUP-TFII, FOG2, and GATA4 in the nitrofen model of CDH. MATERIALS AND METHODS:Pregnant rats were exposed to either olive oil or 100 mg nitrofen on day 9 of gestation (D9). 5 mg/kg of RA was given intraperitoneally on days D18, D19, and D20. The fetuses were recovered by caesarean section on D21, and the diaphragm was carefully examined for the presence of a hernia under a microscope. Left lungs were obtained from CDH fetuses and controls and divided into four groups: control (n = 9), control + RA (n = 9), CDH (n = 9), and CDH + RA (n = 9). The relative mRNA expression levels of COUP-TFII, FOG2, and GATA4 were analyzed in each lung by real-time reverse transcriptase-polymerase chain reaction from cDNA generated by mRNA from pulmonary total RNA. RESULTS:The relative mRNA expression levels of COUP-TFII, FOG2, and GATA4 were significantly increased in CDH + RA lungs compared to control, control + RA, and CDH (P < .05). CONCLUSIONS:Up-regulation of pulmonary gene expression of COUP-TFII, FOG2, and GATA4 after prenatal treatment with retinoic acid in the nitrofen model of CDH suggests that RA may have a therapeutic potential in modulating lung growth. Furthermore, these results support the concept that these proteins work together to regulate downstream target genes that play an important role in the development of lung.

journal_name

J Pediatr Surg

journal_title

Journal of pediatric surgery

authors

Doi T,Sugimoto K,Puri P

doi

10.1016/j.jpedsurg.2009.04.027

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

1933-7

issue

10

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(09)00375-3

journal_volume

44

pub_type

杂志文章

相关文献

JOURNAL OF PEDIATRIC SURGERY文献大全
  • Fetus in fetu--diagnostic criteria and differential diagnosis--a case report and literature review.

    abstract：:Fetus-in-fetu (FIF) is a rare congenital condition in which a vertebrate fetus is incorporated within its twin. The authors report the case of a newborn boy with prenatal ultrasonographic diagnosis of intraabdominal mass, provoking compression of the left kidney. Plain abdominal radiography, ultrasonography, and compu...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章,评审

    doi：10.1016/j.jpedsurg.2003.12.029

    authors： Brand A,Alves MC,Saraiva C,Loío P,Goulão J,Malta J,Palminha JM,Martins M

    更新日期：2004-04-01 00:00:00

  • Predictability model of the need for extracorporeal membrane oxygenation in neonates with meconium aspiration syndrome treated with inhaled nitric oxide.

    abstract：BACKGROUND:As the use of inhaled nitric oxide (iNO) resulted in a decline in the need for extracorporeal membrane oxygenation (ECMO) in neonates with hypoxic respiratory failure, iNO has become an accepted treatment modality even in non-ECMO centers. However, because not all neonates respond to iNO, the timely identifi...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2005.03.061

    authors： Friedlich P,Noori S,Stein J,Shin C,Burns C,Ramanathan R,Seri I

    更新日期：2005-07-01 00:00:00

  • Antenatal dexamethasone enhances endothelin-1 synthesis and gene expression in the heart in congenital diaphragmatic hernia in rats.

    abstract：BACKGROUND/PURPOSE:Although high levels of endothelin-1 (ET-1) in plasma may be relevant in certain pathophysiologic states, such as pulmonary hypertension accompanying congenital diaphragmatic hernia (CDH), experimental evidence favors a local, paracrine, or autocrine role for ET-1 in most tissues. Evidence of ET-1 pr...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1053/jpsu.2002.36185

    authors： Guarino N,Puri P

    更新日期：2002-11-01 00:00:00

  • Stitch granulomas following inguinal herniotomy: a 10-year review.

    abstract：:During the years 1982 through 1991, stitch granulomata complicated 15 of 2,447 inguinal herniotomies. The lesions were diagnosed 3 to 120 months (mean +/- SE, 2.46 +/- 0.65 years) following surgery. Granulomata were associated with male sex (P = .02), emergency herniotomy (P = 0.016), surgery during the neonatal perio...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/0022-3468(93)90442-n

    authors： Nagar H

    更新日期：1993-11-01 00:00:00

  • Experience of splenectomy and cholecystectomy in children with chronic haemolytic anaemia.

    abstract：:Since 1973, 419 children (233 boys, 186 girls) with chronic haemolytic anaemia (mean age, 10.2 +/- 3.5 years) have been splenectomised. Fifty-three (12.6%) have also been cholecystectomised because of cholelithiasis. Between 1973 and 1982, cholecystectomy and splenectomy were performed at the same time in symptomatic ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(89)80502-0

    authors： Pappis CH,Galanakis S,Moussatos G,Keramidas D,Kattamis C

    更新日期：1989-06-01 00:00:00

  • Successful management of concomitant omphalocele, accessory hepatic lobe, and biliary atresia in a 44-day-old boy.

    abstract：:We report the second case in literature of a boy with the association of large omphalocele, accessory hepatic lobe, and biliary atresia, and the first successful treatment. The patient was submitted to a surgical treatment at 44 days of life, including Kasai procedure, correction of the remnant abdominal wall defect, ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章,评审

    doi：10.1016/j.jpedsurg.2005.06.034

    authors： Pereira RM,Simões e Silva AC,Leite VH,Lanna JC,Guimarães JT

    更新日期：2005-10-01 00:00:00

  • Is the outcome of the left colon antegrade continence enema better than that of the right colon antegrade continence enema?

    abstract：BACKGROUND/PURPOSE:The purpose of this report was to review the results of the antegrade continence enema (ACE) procedure and to compare the outcomes of right and left colon ACEs in children. METHODS:Thirty patients who underwent an ACE between 1998 and 2005 were analyzed. Data were obtained based on the following par...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2008.08.034

    authors： Kim HY,Jung SE,Lee SC,Park KW,Kim WK

    更新日期：2009-04-01 00:00:00

  • Postoperative chylothorax in children: differences between vascular and traumatic origin.

    abstract：:Twenty-four children with postoperative chylothorax were encountered among 1,264 consecutive thoracic operations over a 7-year period and form the basis of this study. Chylothorax was caused by direct lesion to the thoracic duct or lymphatic vessels in 17 patients and was associated with superior vena cava (SVC) obstr...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/0022-3468(91)90696-q

    authors： Le Coultre C,Oberhänsli I,Mossaz A,Bugmann P,Faidutti B,Belli DC

    更新日期：1991-05-01 00:00:00

  • Experimental model for transanal endorectal pull-through surgery. Technique of De la Torre and Ortega.

    abstract：BACKGROUND:We describe an experimental model for transanal endorectal pull-through surgery using the method of de la Torre and Ortega that can be used for training purposes in experimental laboratories. METHODS:Ten rabbits were submitted to the transanal endorectal pull-through technique of de la Torre and Ortega. Ani...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2005.06.031

    authors： Takegawa B,Ortolan EP,Rodrigues AM,Chambô F,Almeida e Paula Fd

    更新日期：2005-10-01 00:00:00

  • Dynamic MRI (dMRI) as a guide to therapy in children and adolescents with persistent full thickness rectal prolapse: a single centre review.

    abstract：INTRODUCTION:Full thickness rectal prolapse (FTRP) tends to be self-limiting in children and is usually managed expectantly. However, it may persist and therefore requires surgical correction. There is no consensus upon operative management, and no one procedure has uniformly good outcomes. The aim of this study was to...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2012.08.006

    authors： Campbell AM,Murphy J,Charlesworth PB,Bhan C,Jarvi K,Power N,Ward HC,Williams NS

    更新日期：2013-03-01 00:00:00

  • Intestinal strangulation between two vertebra following an axial dislocation of L1/L2.

    abstract：:An exceptional cause of intestinal obstruction is reported. Ileus is an 8-yr-old boy persisted for 9 days after successful reduction of an axial dislocation of L1 on L2. At laparotomy, a paraduodenal hernia with bowel strangulated between the bodies of L1 and L2 was discovered. The successful treatment consisted of cl...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(80)80017-0

    authors： Metaizeau JP,Prévot J,Schmitt M,Bretagne MC

    更新日期：1980-04-01 00:00:00

  • Diaphragmatic agenesis as a distinct clinical entity.

    abstract：:Anatomically, diaphragmatic agenesis (DA) is the most extreme form of congenital diaphragmatic defect, but clinically it has not been defined separately from Bochdalek's hernia (BH). Between 1986 and 1992, the authors treated 55 neonates who had diaphragmatic defects. Forty-eight of these cases presented within 24 hou...

    journal_title：Journal of pediatric surgery

    pub_type： 临床试验,杂志文章

    doi：10.1016/0022-3468(95)90599-5

    authors： Tsang TM,Tam PK,Dudley NE,Stevens J

    更新日期：1995-01-01 00:00:00

  • Pediatric gastric adenocarcinoma: A National Cancer Data Base review.

    abstract：PURPOSE:We sought to compare the presentation, management, and outcomes in gastric adenocarcinoma cancer for pediatric and adult patients. METHODS:Using the 2004 to 2014 National Cancer Database (NCDB), patients ≤21 years (pediatric) were retrospectively compared to >21 years (adult). Chi-squared tests were used to co...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2019.01.048

    authors： Tessler RA,Dellinger M,Richards MK,Goldin AB,Beierle EA,Doski JJ,Goldfarb M,Langer M,Nuchtern JG,Raval MV,Vasudevan S,Gow KW

    更新日期：2019-05-01 00:00:00

  • Tension gastrothorax.

    abstract：BACKGROUND:Tension gastrothorax develops when the stomach herniated through a congenital diaphragmatic defect into the thorax is massively distended by trapped air. The authors present 5 cases and discuss the diagnostic and therapeutic management. CASE REPORTS:Four children, aged 3, 4, 6, and 13 months, presented with...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2005.05.079

    authors： Horst M,Sacher P,Molz G,Willi UV,Meuli M

    更新日期：2005-09-01 00:00:00

  • Patterns of injury in children.

    abstract：:Trauma is the leading cause of death for children over 1 year of age. This study was undertaken to identify the patterns of injury among children admitted to a regional pediatric trauma center. During a 34-month period, 3,472 injured children were consecutively admitted to a regional pediatric trauma center. Data were...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(05)80169-1

    authors： Peclet MH,Newman KD,Eichelberger MR,Gotschall CS,Guzzetta PC,Anderson KD,Garcia VF,Randolph JG,Bowman LM

    更新日期：1990-01-01 00:00:00

  • Decrease in hepatic circulation induces hepatic fibrosis in a neonatal piglet model with short bowel syndrome.

    abstract：BACKGROUND:Regarding the complications associated with short bowel syndrome (SBS), progressive liver failure is one of the most severe complications known to occur: Although several studies have suggested that many factors interactively influence this clinical condition we investigated the relationship between hepatic ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2005.06.037

    authors： Taguchi S,Masumoto K,Yamanouchi T,Suita S

    更新日期：2005-10-01 00:00:00

  • Prenatal diagnosis of esophageal atresia.

    abstract：:The prenatal sonographic detection of esophageal atresia (EA) has been possible for more than a decade and relies on the finding of a small or absent fetal stomach bubble associated with maternal polyhydramnios. The aims of this study were to assess the accuracy of this technique and to determine whether the outcome o...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/0022-3468(95)90480-8

    authors： Stringer MD,McKenna KM,Goldstein RB,Filly RA,Adzick NS,Harrison MR

    更新日期：1995-09-01 00:00:00

  • External caliper-based measurements of the modified percent depth as an alternative to cross-sectional imaging for assessing the severity of pectus excavatum.

    abstract：BACKGROUND:Cross-sectional imaging (CSI) may be clinically unnecessary in the evaluation of pectus excavatum (PE). The purpose of our study was to prospectively evaluate the accuracy and reliability of the modified percent depth (MPD), derived from caliper-based external measurements, in identifying PE. METHODS:Childr...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jpedsurg.2020.02.053

    authors： Bludevich BM,Kauffman JD,Litz CN,Farach SM,DeRosa JC,Wharton K,Potthast K,Danielson PD,Snyder CW,Chandler NM

    更新日期：2020-06-01 00:00:00

  • Intraoperative localization of small intestinal bleeding in an infant by methylene blue injection: a case report.

    abstract：:During the evaluation of patients with profuse gastrointestinal bleeding, it is often difficult to accurately localize bleeding sites in the small intestine. Moreover, during laparotomy, there may be no intraoperative findings to allow identification and resection of the bleeding lesion. Here the authors report a case...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(98)90209-3

    authors： Mazziotti MV,Muldowney S,Darcy M,Hackett BP,Skinner MA

    更新日期：1998-05-01 00:00:00

  • The 're-do' chest wall deformity correction.

    abstract：BACKGROUND:A small percentage of patients who undergo surgical correction of a chest wall deformity will have results so unsatisfactory that a second procedure, the so-called "re-do," will be required. CONCLUSIONS:The literature contains very little information regarding the technique and results of these procedures. ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(97)90299-2

    authors： Ellis DG,Snyder CL,Mann CM

    更新日期：1997-09-01 00:00:00

  • The current state of evidence-based pediatric surgery.

    abstract：BACKGROUND:The efficiency of medical care in the United States has become intensely scrutinized with expectations from patients, families, payors, lawmakers, and, currently, the President. The most effective vehicle to bring more efficient care is the employment of evidence-based medicine whenever possible. Evidence-ba...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章,评审

    doi：10.1016/j.jpedsurg.2010.05.008

    authors： Ostlie DJ,St Peter SD

    更新日期：2010-10-01 00:00:00

  • Adnexal torsion in children may have a catastrophic sequel: asynchronous bilateral torsion.

    abstract：BACKGROUND/PURPOSE:Adnexal torsion is a serious condition that frequently may result in ovarian removal, and there always is a risk of castration if the contralateral ovary undergo torsion as well. In this study, the authors present their experience with adnexal torsion in 15 children and describe a catastrophic event,...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章,评审

    doi：10.1053/jpsu.2002.36195

    authors： Ozcan C,Celik A,Ozok G,Erdener A,Balik E

    更新日期：2002-11-01 00:00:00

  • Surgical implications of chronic pancreatitis.

    abstract：:Surgical experience with 9 patients with chronic pancreatitis is reviewed. Vague, atypical abdominal pain and obstructive jaundice were the most common form of presentation. Serum amylase was elevated in less than half the patients. Ultrasound, ERCP, and operative cholangiopancreatography were the most helpful studies...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(82)80468-5

    authors： O'Neill JA Jr,Greene H,Grishan FK

    更新日期：1982-12-01 00:00:00

  • Sirenomelia in an identical twin: a case report.

    abstract：:Sirenomelia, or the mermaid syndrome, is the most extreme example of the caudal regression syndrome. It invariably presents with lower limb fusion, sacral and pelvic bony anomalies, absent external genitalia, anal imperforation, and renal agenesis or dysgenesis. Because of the resultant oligohydramnios, these infants ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/0022-3468(91)90614-y

    authors： Di Lorenzo M,Brandt ML,Veilleux A

    更新日期：1991-11-01 00:00:00

  • Giant ileal duplication with extensive gastric heterotopia.

    abstract：:A rare case of ileal duplication in a 6-year-old boy is presented. The duplicated area is just like an additional ectopic stomach both in radiologic and pathologic examination. The patient was operated on because of intestinal obstruction. ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1053/jpsu.2002.29441

    authors： Geramizadeh B,Frootan HR,Eghbali S,Rasekhi A

    更新日期：2002-01-01 00:00:00

  • Sentinel lymph node biopsy in children and adolescents with malignant melanoma.

    abstract：BACKGROUND/PURPOSE:Sentinel lymph node biopsy (SLNB) provides valuable staging information for adult patients presenting with clinically localized cutaneous melanoma. There are little data pertaining to the use of SLNB in the pediatric melanoma population. The objective of this study is to investigate the use of SLNB i...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(03)00193-3

    authors： Toro J,Ranieri JM,Havlik RJ,Coleman JJ 3rd,Wagner JD

    更新日期：2003-07-01 00:00:00

  • A randomized controlled trial of elective preterm delivery of fetuses with gastroschisis.

    abstract：BACKGROUND:Elective preterm delivery of the fetus with gastroschisis may help to limit injury to the extruded fetal gut and thus promote faster recovery of neonatal gut function and earlier hospital discharge. This hypothesis has not previously been tested in a prospective randomized controlled trial. METHODS:Between ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jpedsurg.2005.07.047

    authors： Logghe HL,Mason GC,Thornton JG,Stringer MD

    更新日期：2005-11-01 00:00:00

  • Urinary tract anomalies and urinary tract dysfunction in children with Hirschsprung disease-Is follow-up indicated?

    abstract：BACKGROUND/PURPOSE:Urinary tract function in children with Hirschsprung disease (HD) is rarely considered. AIM:to evaluate the prevalence of urinary tract anomalies and dysfunction in children with HD compared to controls. METHODS:This was an observational cross sectional case-control study. Children with HD who unde...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2018.12.006

    authors： Granéli C,Marschall Sima H,Börjesson A,Hagelsteen K,Arnbjörnsson E,Stenström P

    更新日期：2019-10-01 00:00:00

  • Anti-VEGF antibody in experimental hepatoblastoma: suppression of tumor growth and altered angiogenesis.

    abstract：BACKGROUND:Hepatoblastoma is the most common primary hepatic malignancy of childhood, frequently presenting as advanced disease. Vascular endothelial growth factor (VEGF) is an endothelial mitogen and survival factor critical to growth and angiogenesis in many human cancers. Inhibition of VEGF effectively suppresses tu...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1053/jpsu.2003.50099

    authors： McCrudden KW,Hopkins B,Frischer J,Novikov A,Huang J,Kadenhe A,New T,Yokoi A,Yamashiro DJ,Kandel JJ,Middlesworth W

    更新日期：2003-03-01 00:00:00

  • PIC lines save money and hasten discharge in the care of children with ruptured appendicitis.

    abstract：UNLABELLED:With the need for physicians to help control the rising cost of health care, consideration should be made, when appropriate, to shift more expensive inpatient care (IPC) to the less costly home care (HC) setting. The management of ruptured appendicitis (RA) includes appendectomy and intravenous (IV) antibiot...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/0022-3468(94)90327-1

    authors： Stovroff MC,Totten M,Glick PL

    更新日期：1994-02-01 00:00:00