Infantile intestinal leiomyosarcoma is prognostically favorable despite histologic aggressiveness: case report and literature review.

Abstract:

:Intestinal leiomyosarcomas in children are extremely rare. The authors present a case of infantile intestinal leiomyosarcoma of the colon that was resected and was classified histologically as grade 2 because of abundant mitoses. The tumor cells infiltrated the submucosa and the serosal surface. Immunohistochemically, these cells were positive for alpha-smooth muscle actin but not for CD34 or CD117, by which the tumor was differentiated from gastrointestinal stromal tumor (GIST). The patient underwent follow-up without adjuvant therapy and is now doing well with no evidence of the disease for 42 months. Based on the current case and a review of 18 reported cases, it is concluded that infantile intestinal leiomyosarcoma, which is differentiated from GIST, has a favorable prognosis even when the histologic appearance is suggestive of aggressive biological characteristics. Adjuvant therapy is unnecessary when tumors are completely resected.

journal_name

J Pediatr Surg

authors

Yamamoto H,Tsuchiya T,Ishimaru Y,Kisaki Y,Fujino J,Uchida H,Yoshida M,Mori Y,Ikeda H

doi

10.1016/j.jpedsurg.2004.04.021

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

1257-60

issue

8

eissn

0022-3468

issn

1531-5037

pii

S0022346804002726

journal_volume

39

pub_type

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