Syphilis of the oropharynx: Case series of "The Great Masquerader".

Abstract:

OBJECTIVE:Syphilis is a sexually transmitted infection with various presentations. Although, oropharyngeal manifestations are known to occur, the purpose of this study is to present the first case series in which the lesions were initially mistaken for human-papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC). METHODS:A multi-institutional retrospective review. RESULTS:Six cases of oropharyngeal syphilis were initially thought to be secondary to OPSCC due to presentation. Symptoms were vague and exam findings consisted of either a tonsillar or base of tongue mass, or lymphadenopathy. Biopsies were negative for OPSCC. Further workup diagnosed syphilis, with resolution of symptoms and lesions after antibiotic treatment. CONCLUSIONS:Head and neck manifestations of syphilis have been reported in the literature. However, this is the first series reporting on oropharyngeal syphilis masquerading as HPV-related OPSCC. Ultimately, otolaryngologists must maintain a high suspicion for syphilis in order to ensure prompt diagnosis and treatment.

journal_name

Am J Otolaryngol

authors

Jategaonkar A,Klimczak J,Agarwal J,Badhey A,Portnoy WM,Damiano A,Chai RL

doi

10.1016/j.amjoto.2019.01.005

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

143-146

issue

2

eissn

0196-0709

issn

1532-818X

pii

S0196-0709(18)31135-9

journal_volume

40

pub_type

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