Abstract:
AIMS:To evaluate the protective efficacy of Pediococcus pentosaceus GS4 in cadmium (Cd)-induced toxicity in Swiss albino mice. METHODS AND RESULTS:The previously reported probiotic P. pentosaceus GS4 interaction with Cd was evaluated experimentally. Swiss albino mice were segregated randomly into three different groups containing nine animals each. The binding ability of P. pentosaceus GS4 and Cd was demonstrated by atomic absorption spectrometry, Fourier transform infrared spectroscopy and scanning electron microscopy analysis respectively. Cd challenge was attenuated by the P. pentosaceus GS4 treatment and was evaluated by estimating Cd level in liver and faeces, corresponding biomarkers for toxicity in liver and intestines and histopathological analysis with brush border membrane (BBM) integrity. Results showed that P. pentosaceus GS4 bound Cd effectively. Pediococcus pentosaceus GS4 intervention significantly enhanced faecal evacuation of Cd with an effect of reduced tissue deposition. Histologically, Cd-induced gut was found significantly replenished with lactobacilli in addition to reduced hyperplasia, lowered lymphocytes infiltration and enhancement of BBM-based disaccharidases, proving its role in protecting membrane integrity. CONCLUSIONS:Probiotic P. pentosaceus GS4 efficiently alleviated toxicity from vital organs such as liver and intestine caused by Cd exposure in a murine model. SIGNIFICANCE AND IMPACT OF THE STUDY:Intervention of P. pentosaceus GS4 alleviated Cd-induced toxicity, and thus it may be employed therapeutically to protect Cd toxicity.
journal_name
J Appl Microbioljournal_title
Journal of applied microbiologyauthors
Dubey V,Mishra AK,Ghosh AR,Mandal BKdoi
10.1111/jam.14195subject
Has Abstractpub_date
2019-04-01 00:00:00pages
1233-1244issue
4eissn
1364-5072issn
1365-2672journal_volume
126pub_type
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journal_title:Journal of applied microbiology
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journal_title:Journal of applied microbiology
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journal_title:Journal of applied microbiology
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更新日期:2021-01-07 00:00:00
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journal_title:Journal of applied microbiology
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journal_title:Journal of applied microbiology
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doi:10.1046/j.1365-2672.2001.01458.x
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journal_title:Journal of applied microbiology
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journal_title:Journal of applied microbiology
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journal_title:Journal of applied microbiology
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journal_title:Journal of applied microbiology
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journal_title:Journal of applied microbiology
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更新日期:2017-12-01 00:00:00
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journal_title:Journal of applied microbiology
pub_type: 杂志文章
doi:10.1111/j.1365-2672.2004.02306.x
更新日期:2004-01-01 00:00:00
abstract::An alkalophilic, environmental micro-organism, Bacillus sp. BG-11, has been isolated and characterized. It produced 76 U ml-1 of chitinase in liquid batch fermentation after 72 h of incubation at 50 degrees C using chitin-enriched medium. The molecular weight of purified chitinase was estimated to be 41 kDa by SDS-PAG...
journal_title:Journal of applied microbiology
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journal_title:Journal of applied microbiology
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journal_title:Journal of applied microbiology
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journal_title:Journal of applied microbiology
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更新日期:2001-01-01 00:00:00