当前位置： SCI文献检索 > NEUROPSYCHOLOGIA期刊下所有文献 > DAT genotype modulates striatal processing and long-term memory for items associated with reward and punishment.

DAT genotype modulates striatal processing and long-term memory for items associated with reward and punishment.

Abstract：

:Previous studies have shown that appetitive motivation enhances episodic memory formation via a network including the substantia nigra/ventral tegmental area (SN/VTA), striatum and hippocampus. This functional magnetic resonance imaging (fMRI) study now contrasted the impact of aversive and appetitive motivation on episodic long-term memory. Cue pictures predicted monetary reward or punishment in alternating experimental blocks. One day later, episodic memory for the cue pictures was tested. We also investigated how the neural processing of appetitive and aversive motivation and episodic memory were modulated by dopaminergic mechanisms. To that end, participants were selected on the basis of their genotype for a variable number of tandem repeat polymorphism of the dopamine transporter (DAT) gene. The resulting groups were carefully matched for the 5-HTTLPR polymorphism of the serotonin transporter gene. Recognition memory for cues from both motivational categories was enhanced in participants homozygous for the 10-repeat allele of the DAT, the functional effects of which are not known yet, but not in heterozygous subjects. In comparison with heterozygous participants, 10-repeat homozygous participants also showed increased striatal activity for anticipation of motivational outcomes compared to neutral outcomes. In a subsequent memory analysis, encoding activity in striatum and hippocampus was found to be higher for later recognized items in 10-repeat homozygotes compared to 9/10-repeat heterozygotes. These findings suggest that processing of appetitive and aversive motivation in the human striatum involve the dopaminergic system and that dopamine plays a role in memory for both types of motivational information. In accordance with animal studies, these data support the idea that encoding of motivational events depends on dopaminergic processes in the hippocampus.

journal_name

Neuropsychologia

journal_title

Neuropsychologia

authors

Wittmann BC,Tan GC,Lisman JE,Dolan RJ,Düzel E

doi

10.1016/j.neuropsychologia.2013.07.018

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

2184-93

issue

11

eissn

0028-3932

issn

1873-3514

pii

S0028-3932(13)00247-9

journal_volume

51

pub_type

杂志文章

相关文献

NEUROPSYCHOLOGIA文献大全
  • Neural correlates for perception of companion animal photographs.

    abstract：:Anthrozoological neuroscience, which we propose as the use of neuroscience techniques to study human-animal interaction, may help to elucidate mechanisms underlying the associated psychological, physiological, and other purported health effects. This preliminary study investigates the neural response to animal photogr...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2016.03.018

    authors： Hayama S,Chang L,Gumus K,King GR,Ernst T

    更新日期：2016-05-01 00:00:00

  • Time course and hemispheric lateralization effects of complex pitch processing: evoked magnetic fields in response to rippled noise stimuli.

    abstract：:To delineate the time course and processing stages of pitch encoding at the level of the supratemporal plane, the present study recorded evoked magnetic fields in response to rippled noise (RN) stimuli. RN largely masks simple tonotopic representations and addresses pitch processing within the temporal domain (periodi...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2004.04.022

    authors： Hertrich I,Mathiak K,Lutzenberger W,Ackermann H

    更新日期：2004-01-01 00:00:00

  • The influence of time awake and circadian rhythm upon performance on a frontal lobe task.

    abstract：:Previous research has suggested a time-of-day effect for response inhibition on a task known to be dependent on frontal lobe function. We used a forced desynchronisation protocol to separate effects of circadian and sleep homeostat processes on a modified version of this task. Fourteen healthy young adults followed an...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2006.12.012

    authors： Harrison Y,Jones K,Waterhouse J

    更新日期：2007-04-09 00:00:00

  • Factor analysis and the cerebral hemispheres: temporal, occipital and frontal functions.

    abstract：:Three experiments are reported that use a number of lateralized tasks believed to draw on processes localized to the temporal, occipital or frontal lobes. Oblique factor analyses of the resultant asymmetries indicate the existence of nine lateralized functions, characterized as auditory lexical, facial figural, facial...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/0028-3932(92)90049-r

    authors： Boles DB

    更新日期：1992-11-01 00:00:00

  • Pseudoneglect in line bisection judgement is associated with a modulation of right hemispheric spatial attention dominance in right-handers.

    abstract：:The objective of this study was to validate a line bisection judgement (LBJ) task for use in investigating the lateralized cerebral bases of spatial attention in a sample of 51 right-handed healthy participants. Using functional magnetic resonance imaging (fMRI), the participants performed a LBJ task that was compared...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2016.11.024

    authors： Zago L,Petit L,Jobard G,Hay J,Mazoyer B,Tzourio-Mazoyer N,Karnath HO,Mellet E

    更新日期：2017-01-08 00:00:00

  • Problem-solving without awareness: an ERP investigation.

    abstract：:When subjects are given the balls-and-boxes problem-solving task (Kotovsky & Simon, 1990), they move rapidly towards the goal after an extended exploratory phase, despite having no awareness of how to solve the task. We investigated possible non-conscious learning mechanisms by giving subjects three runs of the task w...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2010.06.029

    authors： Paynter CA,Kotovsky K,Reder LM

    更新日期：2010-08-01 00:00:00

  • Auditory rhyme processing in expert freestyle rap lyricists and novices: An ERP study.

    abstract：:Music and language processing share and sometimes compete for brain resources. An extreme case of such shared processing occurs in improvised rap music, in which performers, or 'lyricists', combine rhyming, rhythmic, and semantic structures of language with musical rhythm, harmony, and phrasing to create integrally me...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2019.03.022

    authors： Cross K,Fujioka T

    更新日期：2019-06-01 00:00:00

  • The effects of repetition on allocation of study time and judgements of learning in Alzheimer's disease.

    abstract：:Greene et al. [12] suggest that Alzheimer's disease (AD) patients approach repeated trials in a learning test as if they are single unrelated trials. Previous research [7] indicates that AD patients do not have explicit memory for item repetition when asked at test how many times a word was presented, but they do show...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/s0028-3932(99)00142-6

    authors： Moulin CJ,Perfect TJ,Jones RW

    更新日期：2000-01-01 00:00:00

  • Creativity and the brain: uncovering the neural signature of conceptual expansion.

    abstract：:Neurophysiological studies of creativity thus far have not allowed for clear conclusions to be made regarding the specific neural underpinnings of such complex cognition due to overgeneralizations concerning the creativity construct, heterogeneity in the type of creativity tasks used, and the questionable efficacy of ...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2012.04.015

    authors： Abraham A,Pieritz K,Thybusch K,Rutter B,Kröger S,Schweckendiek J,Stark R,Windmann S,Hermann C

    更新日期：2012-07-01 00:00:00

  • Influence of perceptual and semantic conflicts between the two halves of chimeric stimuli on the expression of visuo-spatial neglect.

    abstract：:We investigated how perceptual and semantic relationships between the left and right half of chimeric stimuli influence overt and covert visual processing by asking eight right brain damaged (RBD) patients with hemispatial neglect to identify complete, half-, and chimeric drawings. Chimeric stimuli belonged in one of ...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/s0028-3932(96)00105-4

    authors： Peru A,Moro V,Avesani R,Aglioti S

    更新日期：1997-05-01 00:00:00

  • Processing conflicting information: facilitation, interference, and functional connectivity.

    abstract：:When a conflict task involves congruent, neutral, and incongruent conditions, it is possible to examine facilitation (neutral vs. congruent) and interference (incongruent vs. neutral) components. Very few studies investigated the brain areas that are specifically involved in facilitation or interference. We used funct...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2008.05.025

    authors： Cohen Kadosh R,Cohen Kadosh K,Henik A,Linden DE

    更新日期：2008-10-01 00:00:00

  • Association between amygdala response to emotional faces and social anxiety in autism spectrum disorders.

    abstract：:Difficulty interpreting facial expressions has been reported in autism spectrum disorders (ASD) and is thought to be associated with amygdala abnormalities. To further explore the neural basis of abnormal emotional face processing in ASD, we conducted an fMRI study of emotional face matching in high-functioning adults...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2010.07.022

    authors： Kleinhans NM,Richards T,Weaver K,Johnson LC,Greenson J,Dawson G,Aylward E

    更新日期：2010-10-01 00:00:00

  • Stress-evoking emotional stimuli exaggerate deficits in motor function in Parkinson's disease.

    abstract：:Recent animal studies have shown that stress can profoundly affect motor behaviour and worsen motor deficits associated with Parkinson's disease (PD) by acting on the dopaminergic system, possibly due to stress-associated emotional changes. However, systematic investigation of the influence of acute emotional stressor...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2018.03.006

    authors： Blakemore RL,MacAskill' MR,Shoorangiz R,Anderson TJ

    更新日期：2018-04-01 00:00:00

  • Effects of practice and delays on learning and retention of skilled tool use in Parkinson's disease.

    abstract：:Previous research has shown that individuals with Parkinson's disease (PD) show preserved learning of tool-related motor skills, while retention was impaired after a three-week delay, possibly as a result of striatal dysfunction. The goal of the current study was to identify if shorter delays and more extensive practi...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2017.01.020

    authors： Fernandes HA,Park NW,Almeida QJ

    更新日期：2017-02-01 00:00:00

  • Laterality effects in normal subjects' recognition of familiar faces, voices and names. Perceptual and representational components.

    abstract：:A growing body of evidence suggests that a different hemispheric specialization may exist for different modalities of person identification, with a prevalent right lateralization of the sensory-motor systems allowing face and voice recognition and a prevalent left lateralization of the name recognition system. Data su...

    journal_title：Neuropsychologia

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropsychologia.2013.03.009

    authors： Gainotti G

    更新日期：2013-06-01 00:00:00

  • Tactual extinction without anomia: evidence of attentional factors in a patient with a partial callosal disconnection.

    abstract：:Tactual extinction was examined in a 43-yr-old left-handed male patient (MM) with a hematoma in the trunk of the corpus callosum sparing the genu and the ventral part of the splenium as well as the cerebral hemispheres. Experiments I and II showed no deficit in tactual perception nor in the inter-hemispheric transfer ...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/0028-3932(88)90054-1

    authors： Mayer E,Koenig O,Panchaud A

    更新日期：1988-01-01 00:00:00

  • Emotion recognition in Huntington's disease and frontotemporal dementia.

    abstract：:A well-documented feature of Huntington's disease (HD) is disproportionate impairment in the ability to recognise the emotional expression of disgust. However, this finding has been challenged by studies that report no differential disgust impairment and attribute apparent differences across emotions to task difficult...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2008.04.018

    authors： Snowden JS,Austin NA,Sembi S,Thompson JC,Craufurd D,Neary D

    更新日期：2008-09-01 00:00:00

  • The genetic impact (C957T-DRD2) on inhibitory control is magnified by aging.

    abstract：:Healthy aging beyond the age of 65 is characterized by a general decrease in cognitive control over actions: old adults have more difficulty than young adults in stopping overt responses. Responsible for this cognitive decrement is the continuous decline of striatal and extrastriatal dopamine (DA). The resource-modula...

    journal_title：Neuropsychologia

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.neuropsychologia.2013.01.014

    authors： Colzato LS,van den Wildenberg WP,Hommel B

    更新日期：2013-06-01 00:00:00

  • Higher intraindividual variability is associated with more forgetting and dedifferentiated memory functions in old age.

    abstract：:Intraindividual trial-to-trial reaction time (RT) variability is commonly found to be higher in clinical populations or life periods that are associated with impaired cognition. In the present study, higher within-person trial-to-trial RT variability in a perceptual speed task is related to more forgetting and dediffe...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2011.03.013

    authors： Papenberg G,Bäckman L,Chicherio C,Nagel IE,Heekeren HR,Lindenberger U,Li SC

    更新日期：2011-06-01 00:00:00

  • Lexical and syntactic representations in the brain: an fMRI investigation with multi-voxel pattern analyses.

    abstract：:Work in theoretical linguistics and psycholinguistics suggests that human linguistic knowledge forms a continuum between individual lexical items and abstract syntactic representations, with most linguistic representations falling between the two extremes and taking the form of lexical items stored together with the s...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2011.09.014

    authors： Fedorenko E,Nieto-Castañon A,Kanwisher N

    更新日期：2012-03-01 00:00:00

  • Working memory and reward association learning impairments in obesity.

    abstract：:Obesity has been associated with impaired executive functions including working memory. Less explored is the influence of obesity on learning and memory. In the current study we assessed stimulus reward association learning, explicit learning and memory and working memory in healthy weight, overweight and obese indivi...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2014.10.004

    authors： Coppin G,Nolan-Poupart S,Jones-Gotman M,Small DM

    更新日期：2014-12-01 00:00:00

  • The effects of two matched memory tasks on concurrent finger tapping.

    abstract：:In a dual task experiment, subjects were instructed to perform a single finger tapping task whilst either, concurrently memorizing words appearing randomly on a screen in front of them, or concurrently memorizing the positions of the words. Analysis of percentage change scores revealed a significant tapping hand by ta...

    journal_title：Neuropsychologia

    pub_type： 临床试验,杂志文章

    doi：10.1016/0028-3932(94)90074-4

    authors： Towell N,Burton A,Burton E

    更新日期：1994-01-01 00:00:00

  • The role of perceptual reference frames in visual field asymmetries.

    abstract：:The direct access model of hemispheric asymmetry was tested in a letter reflection (normal of reflected) judgement task. In the baseline condition letters were presented in their upright orientation, and reaction times were faster to letters presented in the right visual field than to those presented in the left visua...

    journal_title：Neuropsychologia

    pub_type： 临床试验,杂志文章

    doi：10.1016/0028-3932(88)90037-1

    authors： Robertson LC,Lamb MR

    更新日期：1988-01-01 00:00:00

  • The neural basis of implicit learning and memory: a review of neuropsychological and neuroimaging research.

    abstract：:Memory systems research has typically described the different types of long-term memory in the brain as either declarative versus non-declarative or implicit versus explicit. These descriptions reflect the difference between declarative, conscious, and explicit memory that is dependent on the medial temporal lobe (MTL...

    journal_title：Neuropsychologia

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropsychologia.2013.06.019

    authors： Reber PJ

    更新日期：2013-08-01 00:00:00

  • Emotion recognition following pediatric traumatic brain injury: longitudinal analysis of emotional prosody and facial emotion recognition.

    abstract：:Children with closed head injuries often experience significant and persistent disruptions in their social and behavioral functioning. Studies with adults sustaining a traumatic brain injury (TBI) indicate deficits in emotion recognition and suggest that these difficulties may underlie some of the social deficits. The...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2010.05.029

    authors： Schmidt AT,Hanten GR,Li X,Orsten KD,Levin HS

    更新日期：2010-08-01 00:00:00

  • Reduced specificity in emotion judgment in people with autism spectrum disorder.

    abstract：:There is a conflicting literature on facial emotion processing in autism spectrum disorder (ASD): both typical and atypical performance have been reported, and inconsistencies in the literature may stem from different processes examined (emotion judgment, face perception, fixations) as well as differences in participa...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2017.03.024

    authors： Wang S,Adolphs R

    更新日期：2017-05-01 00:00:00

  • Crossmodal congruency measures of lateral distance effects on the rubber hand illusion.

    abstract：:Body ownership for an artificial hand and the perceived position of one's own hand can be manipulated in the so-called rubber hand illusion. To induce this illusion, typically an artificial hand is placed next to the participant's body and stroked in synchrony with the real hand, which is hidden from view. Our first a...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2009.10.028

    authors： Zopf R,Savage G,Williams MA

    更新日期：2010-02-01 00:00:00

  • Item memory, context memory and the hippocampus: fMRI evidence.

    abstract：:Dual-process models of recognition memory distinguish between the retrieval of qualitative information about a prior event (recollection), and judgments of prior occurrence based on an acontextual sense of familiarity. fMRI studies investigating the neural correlates of memory encoding and retrieval conducted within t...

    journal_title：Neuropsychologia

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropsychologia.2012.06.004

    authors： Rugg MD,Vilberg KL,Mattson JT,Yu SS,Johnson JD,Suzuki M

    更新日期：2012-11-01 00:00:00

  • Cue awareness in avoiding effortful control.

    abstract：:Based on a recent metacognitive account, cognitive effort is the result of an inferential evaluation made over explicitly available cues. Following from this account, we present here a pre-registered experiment that tested the specific hypothesis that explicit awareness of cues that are aligned with cognitive demand i...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2018.05.011

    authors： Dunn TL,Gaspar C,Risko EF

    更新日期：2019-02-04 00:00:00

  • Evidence for intact memory monitoring in Alzheimer's disease: metamemory sensitivity at encoding.

    abstract：:Previous research claiming that there is a metamemory deficit in Alzheimer's Disease (AD) has been based on paradigms in which metamemory judgements are compared with performance. These methods confound predictive accuracy with very poor memory performance. In the experiments presented here this confound is removed by...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/s0028-3932(00)00037-3

    authors： Moulin CJ,Perfect TJ,Jones RW

    更新日期：2000-01-01 00:00:00