Association between amygdala response to emotional faces and social anxiety in autism spectrum disorders.

Abstract:

:Difficulty interpreting facial expressions has been reported in autism spectrum disorders (ASD) and is thought to be associated with amygdala abnormalities. To further explore the neural basis of abnormal emotional face processing in ASD, we conducted an fMRI study of emotional face matching in high-functioning adults with ASD and age, IQ, and gender matched controls. In addition, we investigated whether there was a relationship between self-reported social anxiety and fMRI activation. During fMRI scanning, study participants were instructed to match facial expressions depicting fear or anger. The control condition was a comparable shape-matching task. The control group evidenced significantly increased left prefrontal activation and decreased activation in the occipital lobes compared to the ASD group during emotional face matching. Further, within the ASD group, greater social anxiety was associated with increased activation in right amygdala and left middle temporal gyrus, and decreased activation in the fusiform face area. These results indicate that level of social anxiety mediates the neural response to emotional face perception in ASD.

journal_name

Neuropsychologia

journal_title

Neuropsychologia

authors

Kleinhans NM,Richards T,Weaver K,Johnson LC,Greenson J,Dawson G,Aylward E

doi

10.1016/j.neuropsychologia.2010.07.022

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

3665-70

issue

12

eissn

0028-3932

issn

1873-3514

pii

S0028-3932(10)00317-9

journal_volume

48

pub_type

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