Abstract:
BACKGROUND:Studies investigating short-term exposure to ambient air pollution and heart rate variability (HRV) suggest that particulate matter (PM) exposure is associated with reductions in measures of HRV. Mitochondria are sensitive to PM exposure and may represent a biologically relevant underlying mechanism. However, evidence in children is lacking. OBJECTIVES:Here we examine whether PM has an influence on children's HRV and evaluate whether mitochondrial DNA content (mtDNAc) reflects individual susceptibility. METHODS:Within a panel study in primary school children (aged 9-12 years), we measured HRV in a subset of 60 children on three different days during school-time using four indicators: normal-to-normal intervals (SDNN), square root of mean squared difference of normal-to-normal intervals (rMSSD), high frequency (HF), and low frequency (LF). This resulted in a total number of 150 visits (median number of visits per child: 2.5/child). MtDNAc was measured using qPCR in buccal cells. We measured recent PM exposure at the school. Residential 24-hour mean exposure to PM was modelled with a high resolution spatial temporal model. Mixed-effects models were used to estimate the association between HRV and recent PM exposure and potential effect-modification by mtDNAc. RESULTS:Children were on average [SD] 9.9 [1.2] years and comprised 39 girls. Median [25th-75th] recent outdoor PM2.5 and PM10 exposure at school was 6.20 [2.8-12.8] μg/m3 and 29.3 [24.7-42.0] μg/m3, respectively. In children with low mtDNAc (25th percentile), we observed for each 10 μg/m3 increment in recent PM2.5 exposure a lowering in the LF parameter with 9.76% (95% CI: -16.9 to -1.99%, p = 0.02; pint = 0.007). Children with high mtDNAc did not show this association. For PM10 exposure, we observed an inverse association with three HRV indicators in children with low mtDNAc: -2.24% (95% CI: -4.27 to -0.16%; p = 0.04; pint = 0.02) for SDNN, -5.67% (95% CI: -10.5 to -0.59%; p = 0.03; pint = 0.04) for HF and -6.64% (95% CI: -10.7 to -2.38%; p = 0.003; pint = 0.005) for LF. CONCLUSIONS:HRV is inversely associated with recent PM air pollution, especially in children with low mtDNAc. Our data revealed that mtDNAc determines susceptibility to adverse autonomic effects of recent PM exposure in children.
journal_name
Environ Intjournal_title
Environment internationalauthors
Saenen ND,Provost EB,Cuypers A,Kicinski M,Pieters N,Plusquin M,Vrijens K,De Boever P,Nawrot TSdoi
10.1016/j.envint.2018.11.028subject
Has Abstractpub_date
2019-02-01 00:00:00pages
39-49eissn
0160-4120issn
1873-6750pii
S0160-4120(18)31072-9journal_volume
123pub_type
杂志文章abstract::An internally consistent dataset comprising 103 surficial estuarine sediment samples were collected from Sydney Harbour, Australia and locations south of Sydney. This paper describes the chemical characteristics of the dataset and evaluates its suitability for use in evaluating biological effects-based sediment qualit...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2005.10.006
更新日期:2006-05-01 00:00:00
abstract::The exposure of polycyclic aromatic hydrocarbons (PAHs) can cause wheat leaf chlorosis. Thus, we hypothesize that chloroplast inner structure damage is the reason for leaf chlorosis. This study was conducted with the wheat seedlings exposed to Hoagland nutrient solution containing 1.0 mg L-1 phenanthrene for 9 days. S...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2018.11.074
更新日期:2019-02-01 00:00:00
abstract::Perfluorinated alkyl acids (PFAAs) are emerging environmental contaminants. Possible health effects for humans include increased risk for cancer but the knowledge is limited. In this study serum concentrations of certain perfluorinated sulfonates (PFHxS and PFOS) and carboxylates (PFOA, PFNA, PFDA, PFUnDA) were analyz...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2013.10.005
更新日期:2014-02-01 00:00:00
abstract::Ultrasonic humidifiers provide indoor relief to symptoms caused by dry air and produce aerosols containing both water and minerals that are present in the water that fills the humidifier. This study investigated the spatial distributions, concentrations, and metal and mineral composition of aerosols emitted when an ul...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.105902
更新日期:2020-10-01 00:00:00
abstract::On February 12-15, 2001, more than 200 scientists, engineers, decision makers, and educators participated in a conference on the "Future Directions in Air Quality Research: Ecological, Atmospheric, Regulatory/Policy, and Educational Issues." Important perspectives are summarized from the keynote addresses of noted sci...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/S0160-4120(02)00155-1
更新日期:2003-06-01 00:00:00
abstract::For the purpose of synthesizing a compendium of efforts aimed at environmental pollution control through the use of constructed wetlands systems (CWs) in Ireland, a detailed review of CWs was undertaken. Emphasis was placed on the diverse range of development, practice and researches on CWs technology, placing them in...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2007.06.013
更新日期:2008-01-01 00:00:00
abstract::Serum lipid levels are major risk factors for cardiovascular disease. In addition to diet, exercise, genetics, age and race, serum concentrations of persistent organic pollutants (POPs) influence concentrations of serum lipids. We investigated associations between fasting concentrations of 35 polychlorinated biphenyl ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2014.07.022
更新日期:2014-12-01 00:00:00
abstract::Recently, PM2.5 (atmospheric fine particulate matter with aerodynamic diameter ≤ 2.5 μm) have received so much attention that the observations, source appointment and countermeasures of it have been widely studied due to its harmful impacts on visibility, mood (mental health), physical health, traffic safety, construc...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2015.10.016
更新日期:2016-01-01 00:00:00
abstract::A human biomonitoring (HBM) survey in four areas affected by natural or anthropogenic arsenic pollution was conducted in Italy within the framework of the SEpiAs project. A questionnaire, including the exploration of risk perception (RP) regarding environmental hazards and access to and trust in information, was admin...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2016.07.009
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Metabolomics is a novel tool to explore the biological mechanisms of the health effects of fine particulate matter (PM2.5) air pollution. Very few studies have examined the urinary metabolomic changes associated with PM2.5 exposure. OBJECTIVE:To assess the alternation in urine metabolomics in response to sh...
journal_title:Environment international
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.envint.2019.05.072
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Air pollution control policies resulting from the 1990 Clean Air Act Amendments were aimed at reducing pollutant emissions, ambient concentrations, and ultimately adverse health outcomes. OBJECTIVES:As part of a comprehensive air pollution accountability study, we used a counterfactual study design to estim...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.01.052
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:People experience multiple co-occurring exposures to environmental pollutants, but analyses of multiple exposures have rarely been reported. OBJECTIVES:We used latent class analysis to estimate co-exposures to multiple polycyclic aromatic hydrocarbons (PAH), and tested the associations of latent classes to ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2018.09.016
更新日期:2018-12-01 00:00:00
abstract::Respirometric tests on a soil contaminated by crude oil were performed. Continuous measurements of oxygen and carbon dioxide concentrations and temperature in the soil atmosphere resulted in a large volume of data. Time series and system identification theories were used to analyze data as a biological signal, allowin...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2004.09.013
更新日期:2005-02-01 00:00:00
abstract::Cyanobacterial blooms are a potential health hazard due to the ability of some species to produce toxins that are harmful to other living organisms. This review provides a comprehensive summary of anecdotal and case reports on acute poisonings in animals and humans attributable to cyanotoxin exposure in fresh- and bra...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2016.02.026
更新日期:2016-05-01 00:00:00
abstract::Environmental concerns regarding the potential contamination of soil, surface and ground water due to the presence of soluble metal species in the ash pond leachate is of great importance. Serial batch leaching was carried out simulating the rainwater condition of the study area to understand the behaviour of elements...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/s0160-4120(01)00118-0
更新日期:2002-03-01 00:00:00
abstract::It has been shown that the exposure to airborne particulate matter is one of the most significant environmental risks people face. Since indoor environment is where people spend the majority of time, in order to protect against this risk, the origin of the particles needs to be understood: do they come from indoor, ou...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2017.07.025
更新日期:2017-11-01 00:00:00
abstract::Children's blood-lead concentration (B-Pb) is well studied, but little is known about cadmium (B-Cd) and mercury (B-Hg), in particular for central Europe. Such information is necessary for risk assessment and management. Therefore, we here describe and compare B-Pb, B-Cd and B-Hg in children in six European, and three...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2011.12.001
更新日期:2012-05-01 00:00:00
abstract::Antimicrobial resistance (AMR) is a major global concern, especially in India where the burden of infectious diseases is high and health care spending is low. Here we quantified total coliform, faecal coliforms (FC), carbapenem-resistant enteric bacteria (CRE), blaNDM-1, and three integron genes in samples collected f...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2018.07.004
更新日期:2018-10-01 00:00:00
abstract::This study develops water footprint scenarios for 2050 based on a number of drivers of change: population growth, economic growth, production/trade pattern, consumption pattern (dietary change, bioenergy use) and technological development. The objective the study is to understand the changes in the water footprint (WF...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2013.11.019
更新日期:2014-03-01 00:00:00
abstract::Mulching can effectively maintain and improve soil health and functionality. The mechanisms, however, have not been fully elucidated. Therefore, the effects of temperature on the biogeochemical properties of soil were investigated in the present study in relation to nitrogen management and soil functionality. The resu...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.105092
更新日期:2019-11-01 00:00:00
abstract::Exposure to environmental pollutant organochlorine pesticides (OCPs) and the role of tumour suppressor GSTs gene polymorphisms as well as epigenetic alterations have all been well reported in hepatocarcinogenesis. However, the interplay between environmental risk factors and polymorphic tumour suppressor genes or epig...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.105313
更新日期:2020-01-01 00:00:00
abstract::The aim of the present study was to develop a standardised protocol for the use of Lolium perenne cultures to biomonitor the surroundings of an aluminium smelter. Five ecological stations, which corresponded to air quality network monitoring sites pertaining to the smelter, were selected for study. Cultures of L. pere...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2006.10.004
更新日期:2007-05-01 00:00:00
abstract::Green space has a variety of health benefits. However, little is known about its impact on autism, the fastest-growing neurodevelopmental disorder in children. This study examined the relationship between green space and childhood autism prevalence. Autism count data in 2010 were obtained for 543 of ~560 public elemen...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2017.07.010
更新日期:2017-10-01 00:00:00
abstract::Transfer and toxic effects of two cadmium (Cd) forms, inorganic (CdCl2 dosed rat food) or organic (contaminated snail-based rat food) were studied in Wistar rat. Cd concentrations in rat food were 0 and 2.5 microg Cd g(-1) for both inorganic and organic forms and a high concentration of 100 microg Cd g(-1) was also te...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2007.09.003
更新日期:2008-04-01 00:00:00
abstract::Treated wastewater (TWW) is increasingly used for agricultural irrigation, especially in arid and semi-arid regions. Carbamazepine is among the most frequently detected pharmaceuticals in TWW. Moreover, its uptake and accumulation have been demonstrated in crops irrigated with TWW. A previous controlled trial found th...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.105951
更新日期:2020-10-01 00:00:00
abstract::This article reports an environmental health study on risk identification. It discusses risk factors linked to rural work and pesticide contact in a restricted geographic area and shows the necessity of improving rural workers' health in the central part of Sao Paulo State. The municipality of Bariri, which is the cas...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2005.02.002
更新日期:2005-07-01 00:00:00
abstract::Kuala Lumpur has been undergoing rapid urbanisation process, mainly in infrastructure development. The opening of new township and residential in former tin mining areas, particularly in the heavy mineral- or tin-bearing alluvial soil in Kuala Lumpur, is a contentious subject in land-use regulation. Construction pract...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2017.01.009
更新日期:2017-07-01 00:00:00
abstract::A large number of aromatic compounds and organic nitriles, the two groups of compounds covered in this review, are intermediates, products, by-products or waste products of the chemical and pharmaceutical industries, agriculture and the processing of fossil fuels. The majority of these synthetic substances (xenobiotic...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2008.07.018
更新日期:2009-01-01 00:00:00
abstract::A simple modeling concept was previously applied to study air-foliage exchange of both polybrominated diphenyl ethers (PBDEs) and polycyclic aromatic hydrocarbons (PAHs) using field measurements. In this paper, the predictive capabilities of this framework were tested using an independent set of data collected at the ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2009.02.002
更新日期:2009-08-01 00:00:00
abstract::Increasing ozone concentrations are becoming a severe problem for air pollution in China and have an adverse impact on human health. Here we evaluate premature deaths attributable to long-term exposure to ambient ozone in China between 2013 and 2017 with an air quality model at 5 km resolution and the latest estimates...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.106030
更新日期:2020-11-01 00:00:00