Abstract：
BACKGROUND:People experience multiple co-occurring exposures to environmental pollutants, but analyses of multiple exposures have rarely been reported. OBJECTIVES:We used latent class analysis to estimate co-exposures to multiple polycyclic aromatic hydrocarbons (PAH), and tested the associations of latent classes to body mass index. METHODS:We analyzed National Health and Nutrition Examination Survey (NHANES) 2013-2014 data. The sample included 2354 people aged 6-80 years. Measures included seven urinary PAH metabolites, BMI, and demographic and behavioral covariates. People were classified into mutually exclusive latent classes characterized by unique profiles of multiple PAH exposures. These classes were used as categorical independent variables in weighted multiple regression models with BMI as the dependent measure. Models were analyzed overall and by age groups (6-19, 20-59, and 60 and over.) We compared results using latent classes to results using a summed PAH exposure measure. RESULTS:Five latent classes were identified. Two of these classes were significantly associated with higher BMI overall (p < .0001) and for the two youngest age groups. One of these classes was characterized by high multiple exposures across all PAHs, and one by moderate exposures but relatively high naphthalene and phenanthrene. The summed PAH score was associated with higher BMI only for the youngest age group. CONCLUSIONS:Persons experience multiple co-exposures to PAHs that are related to BMI and obesity across age groups. Latent class analysis provides information on higher order interactions among multiple chemicals that a summed score does not. Future work may apply this approach to other outcomes or types of co-exposures.
journal_name
Environ Intjournal_title
Environment internationalauthors
Hendryx M,Luo Jdoi
10.1016/j.envint.2018.09.016subject
Has Abstractpub_date
2018-12-01 00:00:00pages
227-231issue
Pt 1eissn
0160-4120issn
1873-6750pii
S0160-4120(18)30831-6journal_volume
121pub_type
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