当前位置： SCI文献检索 > ENVIRONMENT INTERNATIONAL期刊下所有文献 > Widespread monitoring of chiral pharmaceuticals in urban rivers reveals stereospecific occurrence and transformation.

Widespread monitoring of chiral pharmaceuticals in urban rivers reveals stereospecific occurrence and transformation.

Abstract：

:The present work aimed to discuss the enantiomeric occurrence of chiral pharmaceuticals including 5 parent compounds (PCs) metoprolol, propranolol, atenolol, venlafaxine and fluoxetine as well as 6 of their transformation products (TPs) in surface water in Beijing. Among which, 9 out of 11 were detected during the two sampling campaigns with N-O-Didesmethylvenlafaxine (NODDV) and α-hydroxymetoprolol confirmed in the catchment for the first time. Metoprolol acid (MTPA) was the most abundant up to 1508 ng L-1, followed by metoprolol and O-desmethylvenlafaxine (ODV). Most compounds showed 100% detection frequency or nearly, while norfluoxetine (the main metabolite of fluoxetine) and 4-hydroxypropranololone (one TP of propranolol) were not detected. Metoprolol (MTP) and venlafaxine (VFX) did not vary significantly between two sampling periods with mean concentrations of 280.7 and 22.9 ng L-1, respectively. Enantiomeric enrichment was observed for venlafaxine, metoprolol and NODDV, where R-venlafaxine was preferentially biotransformed than the S-form through O-desmethylation. Risk assessment indicated that fluoxetine and atenolol could pose harmful effects to aquatic organisms. This work provides enantiospecific profiles of pharmaceutically active compounds (PhACs), and extended the concept of applying the ratio of TPs vs. parent compound plus their enantiomeric traits for quantitative assessment of in situ biodegradation. Due to the considerable contribution by TPs (64% in present study) as well as the unexpected impacts from enantiomeric existence, the stereoselectivity of chiral pollutants during environmental process should be taken into account in future study. To the best of the authors' knowledge, it is the first comprehensive evaluation of chiral pharmaceuticals and transformation products at enantiomeric level in aquatic environment in China, which would facilitate better understanding of their environmental fate.

journal_name

Environ Int

journal_title

Environment international

authors

Ma R,Qu H,Wang B,Wang F,Yu G

doi

10.1016/j.envint.2020.105657

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

105657

eissn

0160-4120

issn

1873-6750

pii

S0160-4120(19)33953-4

journal_volume

138

pub_type

杂志文章

相关文献

ENVIRONMENT INTERNATIONAL文献大全
  • The mortality burden of hourly temperature variability in five capital cities, Australia: Time-series and meta-regression analysis.

    abstract：BACKGROUND:Unstable weather, such as intra- and inter-day temperature variability, can impair the health and shorten the survival time of population around the world. Climate change will cause Earth's surface temperature rise, but has unclear effects on temperature variability, making it urgent to understand the charac...

    journal_title：Environment international

    pub_type： 杂志文章,meta分析,多中心研究

    doi：10.1016/j.envint.2017.09.012

    authors： Cheng J,Xu Z,Bambrick H,Su H,Tong S,Hu W

    更新日期：2017-12-01 00:00:00

  • Effects of maternal exposure to ambient air pollution on newborn telomere length.

    abstract：BACKGROUND:Telomere length (TL) is considered as a surrogate of biological aging and has been related to aging-related diseases. The initial setting of newborn TL has important implications for telomere dynamics in adulthood, and is affected by the intrauterine environment. However, the effects of prenatal air pollutio...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2019.04.064

    authors： Song L,Zhang B,Liu B,Wu M,Zhang L,Wang L,Xu S,Cao Z,Wang Y

    更新日期：2019-07-01 00:00:00

  • Physiologically based kinetic (PBK) modelling and human biomonitoring data for mixture risk assessment.

    abstract：:Human biomonitoring (HBM) data can provide insight into co-exposure patterns resulting from exposure to multiple chemicals from various sources and over time. Therefore, such data are particularly valuable for assessing potential risks from combined exposure to multiple chemicals. One way to interpret HBM data is esta...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2020.105978

    authors： Pletz J,Blakeman S,Paini A,Parissis N,Worth A,Andersson AM,Frederiksen H,Sakhi AK,Thomsen C,Bopp SK

    更新日期：2020-10-01 00:00:00

  • Phytodegradation of extra heavy oil-based drill cuttings using mature reed wetland: an in situ pilot study.

    abstract：:Environmental contamination caused by extra heavy oil-based drill cuttings (DCs) is a major problem in the Liaohe Oilfield, northeastern China. To study the potential effectiveness of the mature reed wetland in removing extra heavy oil contained in drill cuttings, biodegradation of extra heavy oils and study of the ef...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2003.10.003

    authors： Ji GD,Yang YS,Zhou Q,Sun T,Ni JR

    更新日期：2004-06-01 00:00:00

  • EFSA's OpenFoodTox: An open source toxicological database on chemicals in food and feed and its future developments.

    abstract：:Since its creation in 2002, the European Food Safety Authority (EFSA) has produced risk assessments for over 5000 substances in >2000 Scientific Opinions, Statements and Conclusions through the work of its Scientific Panels, Units and Scientific Committee. OpenFoodTox is an open source toxicological database, availabl...

    journal_title：Environment international

    pub_type： 杂志文章,评审

    doi：10.1016/j.envint.2020.106293

    authors： Dorne JLCM,Richardson J,Livaniou A,Carnesecchi E,Ceriani L,Baldin R,Kovarich S,Pavan M,Saouter E,Biganzoli F,Pasinato L,Zare Jeddi M,Robinson TP,Kass GEN,Liem AKD,Toropov AA,Toropova AP,Yang C,Tarkhov A,Georgiadis N

    更新日期：2021-01-01 00:00:00

  • Long-term exposure to ambient source-specific particulate matter and its components and incidence of cardiovascular events - The Heinz Nixdorf Recall study.

    abstract：BACKGROUND:Few studies have examined the risk of long-term exposure to source-specific airborne pollutants on incidence of cerebrovascular and cardiovascular events. OBJECTIVES:We aimed to estimate the effect of long-term exposure to source-specific air pollution and particulate matter (PM) components on incidence of ...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2020.105854

    authors： Rodins V,Lucht S,Ohlwein S,Hennig F,Soppa V,Erbel R,Jöckel KH,Weimar C,Hermann DM,Schramm S,Moebus S,Slomiany U,Hoffmann B

    更新日期：2020-09-01 00:00:00

  • Viral dispersal in the coastal zone: A method to quantify water quality risk.

    abstract：:Waterborne and shellfish-borne enteric viruses associated with wastewater-polluted coastal waters (e.g. Norovirus, Hepatitis A/E viruses, Adenovirus) represent a major threat to human health. Improved understanding of the locations and periods of heightened risks can help target mitigation measures and improve public ...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2019.02.042

    authors： Robins PE,Farkas K,Cooper D,Malham SK,Jones DL

    更新日期：2019-05-01 00:00:00

  • Towards a clean Izmit Bay.

    abstract：:The elongated semi-enclosed Bay of Izmit, which receives both domestic and industrial wastes, has been monitored by measuring its physical and biochemical parameters for 2 years, 1994-1995. It is clear that there are two distinct water masses. The upper layer has been occupied by the less saline (22-26 ppt) waters of ...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/s0160-4120(00)00103-3

    authors： Morkoç E,Okay OS,Tolun L,Tüfekçi V,Tüfekçi H,Legoviç T

    更新日期：2001-01-01 00:00:00

  • An open source physiologically based kinetic model for the chicken (Gallus gallus domesticus): Calibration and validation for the prediction residues in tissues and eggs.

    abstract：:Xenobiotics from anthropogenic and natural origin enter animal feed and human food as regulated compounds, environmental contaminants or as part of components of the diet. After dietary exposure, a chemical is absorbed and distributed systematically to a range of organs and tissues, metabolised, and excreted. Physiolo...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2020.105488

    authors： Lautz LS,Nebbia C,Hoeks S,Oldenkamp R,Hendriks AJ,Ragas AMJ,Dorne JLCM

    更新日期：2020-03-01 00:00:00

  • Association between exposure to fine particulate matter and obesity in children: A national representative cross-sectional study in China.

    abstract：BACKGROUND:Childhood obesity is a global health issue, and limited evidence suggests that air pollution may be a contributing factor. This study aims to examine whether exposure to fine particulate matter (PM2.5) is associated with obesity status in a nationally representative sample of schoolchildren in China. METHOD...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2020.105950

    authors： Guo Q,Xue T,Jia C,Wang B,Cao S,Zhao X,Zhang Q,Zhao L,Zhang JJ,Duan X

    更新日期：2020-10-01 00:00:00

  • Pesticide exposure and cancer among rural workers from Bariri, Sao Paulo State, Brazil.

    abstract：:This article reports an environmental health study on risk identification. It discusses risk factors linked to rural work and pesticide contact in a restricted geographic area and shows the necessity of improving rural workers' health in the central part of Sao Paulo State. The municipality of Bariri, which is the cas...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2005.02.002

    authors： de Brito Sá Stoppelli IM,Crestana S

    更新日期：2005-07-01 00:00:00

  • Occurrence and fate of hormone steroids in the environment.

    abstract：:Hormone steroids are a group of endocrine disruptors, which are excreted by humans and animals. In this paper, we briefly review the current knowledge on the fate of these steroids in the environment. Natural estrogenic steroids estrone (E1), 17beta-estradiol (E2) and estriol (E3) all have a solubility of approximatel...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/s0160-4120(02)00075-2

    authors： Yin GG,Kookana RS,Ru YJ

    更新日期：2002-12-01 00:00:00

  • Radon level in dwellings and its correlation with uranium and radium content in some areas of Himachal Pradesh, India.

    abstract：:LR- 115 plastic track detectors have been used to measure indoor radon level in some dwellings of Una district, Himachal Pradesh, India. The annual average radon concentration in dwellings in most of the villages falls in the range of the action level recommended by the International Commission on Radiological Protect...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/s0160-4120(02)00012-0

    authors： Singh S,Kumar A,Singh B

    更新日期：2002-04-01 00:00:00

  • Potential human health benefits of antibiotics used in food animals: a case study of virginiamycin.

    abstract：:Risk management of food-animal antibiotics has reached a crucial juncture for public health officials worldwide. While withdrawals of animal antibiotics previously used to control animal bacterial illnesses are being encouraged in many countries, the human health impacts of such withdrawals are only starting to be und...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2004.10.012

    authors： Cox LA Jr

    更新日期：2005-05-01 00:00:00

  • Investigation of polycyclic aromatic hydrocarbon level in blood and semen quality for residents in Pearl River Delta Region in China.

    abstract：:This study is the first one investigating the correlation between the concentration of polycyclic aromatic hydrocarbon (PAHs) in blood and semen qualities for residents in the Pearl River Delta (PRD) region in China. Blood samples from 53 infertile volunteers were studied for measures of semen quality and 16 PAHs. Inf...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2013.08.003

    authors： Song XF,Chen ZY,Zang ZJ,Zhang YN,Zeng F,Peng YP,Yang C

    更新日期：2013-10-01 00:00:00

  • Differences in the seasonal variation of brominated and phosphorus flame retardants in office dust.

    abstract：:This study documents the temporal variability in concentrations of flame retardants (FRs) in floor dust from three offices in Beijing, China. Dust from Office A (OAD) was collected weekly from March to August, 2012, and sampling of dust from Office B and C (OBD and OCD) was conducted fortnightly (each two weeks) from ...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2013.12.011

    authors： Cao Z,Xu F,Covaci A,Wu M,Yu G,Wang B,Deng S,Huang J

    更新日期：2014-04-01 00:00:00

  • Comparing human exposure to emerging and legacy flame retardants from the indoor environment and diet with concentrations measured in serum.

    abstract：:This study investigates associations between serum concentrations of emerging and legacy halogenated flame retardants (HFRs) in 46 Norwegian women and measured indoor air and dust concentrations of the HFRs as well as detailed information on diet and household factors. Hexabromobenzene (median 0.03ng/g lipid) and Dech...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2014.10.003

    authors： Cequier E,Marcé RM,Becher G,Thomsen C

    更新日期：2015-01-01 00:00:00

  • Species-specific biomagnification and habitat-dependent trophic transfer of halogenated organic pollutants in insect-dominated food webs from an e-waste recycling site.

    abstract：:Aquatic, amphibious, and terrestrial organisms in or around a pond that was contaminated by e-waste were collected and persistent halogenated organic pollutants (HOPs) for these species were analyzed. Based on the stable isotope and dietary composition, the aquatic and terrestrial food webs and several insect-dominate...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2020.105674

    authors： Liu Y,Luo X,Zeng Y,Tu W,Deng M,Wu Y,Mai B

    更新日期：2020-05-01 00:00:00

  • Changes of nitrogen deposition in China from 1980 to 2018.

    abstract：:China has experienced a dramatic change in atmospheric reactive nitrogen (Nr) emissions over the past four decades. However, it remains unclear how nitrogen (N) deposition has responded to increases and/or decreases in Nr emissions. This study quantitatively assesses temporal and spatial variations in measurements of ...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2020.106022

    authors： Wen Z,Xu W,Li Q,Han M,Tang A,Zhang Y,Luo X,Shen J,Wang W,Li K,Pan Y,Zhang L,Li W,Collett JL Jr,Zhong B,Wang X,Goulding K,Zhang F,Liu X

    更新日期：2020-11-01 00:00:00

  • Pharmaceutical management through environmental product labeling in Sweden.

    abstract：:There is an increased awareness that medicinal products for human use may cause negative effects in the environment. In Sweden a voluntary environmental classification system for drugs has been established in collaboration between producers, authorities and the public health care, and used for five years. The idea is ...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2008.12.008

    authors： Wennmalm A,Gunnarsson B

    更新日期：2009-07-01 00:00:00

  • Modeling multi-level survival data in multi-center epidemiological cohort studies: Applications from the ELAPSE project.

    abstract：BACKGROUND:We evaluated methods for the analysis of multi-level survival data using a pooled dataset of 14 cohorts participating in the ELAPSE project investigating associations between residential exposure to low levels of air pollution (PM2.5 and NO2) and health (natural-cause mortality and cerebrovascular, coronary ...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2020.106371

    authors： Samoli E,Rodopoulou S,Hvidtfeldt UA,Wolf K,Stafoggia M,Brunekreef B,Strak M,Chen J,Andersen ZJ,Atkinson R,Bauwelinck M,Bellander T,Brandt J,Cesaroni G,Forastiere F,Fecht D,Gulliver J,Hertel O,Hoffmann B,de Hoogh K,

    更新日期：2021-02-01 00:00:00

  • Chronic risk assessment of exposure to volatile organic compounds in the atmosphere near the largest Mediterranean industrial site.

    abstract：:This study focuses on characterising the risk of exposure to volatile organic compounds (VOCs) by means of inhalation in people living in the vicinity of the largest chemical production site in the Mediterranean area. Eighty-six VOCs were initially selected for this study based on their adverse environmental and healt...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2011.11.002

    authors： Ramírez N,Cuadras A,Rovira E,Borrull F,Marcé RM

    更新日期：2012-02-01 00:00:00

  • Induction and recovery of CpG site specific methylation changes in human bronchial cells after long-term exposure to carbon nanotubes and asbestos.

    abstract：INTRODUCTION:Inhalation of asbestos induces lung cancer via different cellular mechanisms. Together with the increased production of carbon nanotubes (CNTs) grows the concern about adverse effects on the lungs given the similarities with asbestos. While it has been established that CNT and asbestos induce epigenetic al...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2020.105530

    authors： Öner D,Ghosh M,Coorens R,Bové H,Moisse M,Lambrechts D,Ameloot M,Godderis L,Hoet PHM

    更新日期：2020-04-01 00:00:00

  • Obesity aggravates toxic effect of BPA on spermatogenesis.

    abstract：:Both bisphenol A (BPA) and obesity affect male reproductive system. However, whether there is an interaction between them remains poorly understood. The aim of the present study was to evaluate the interaction between BPA exposure and obesity on semen quality and elucidate the mechanism in humans and animals. We first...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2017.04.014

    authors： Hu W,Dong T,Wang L,Guan Q,Song L,Chen D,Zhou Z,Chen M,Xia Y,Wang X

    更新日期：2017-08-01 00:00:00

  • Review on recent progress in observations, source identifications and countermeasures of PM2.5.

    abstract：:Recently, PM2.5 (atmospheric fine particulate matter with aerodynamic diameter ≤ 2.5 μm) have received so much attention that the observations, source appointment and countermeasures of it have been widely studied due to its harmful impacts on visibility, mood (mental health), physical health, traffic safety, construc...

    journal_title：Environment international

    pub_type： 杂志文章,评审

    doi：10.1016/j.envint.2015.10.016

    authors： Liang CS,Duan FK,He KB,Ma YL

    更新日期：2016-01-01 00:00:00

  • A comparative metagenomic and spectroscopic analysis of soils from an international point of entry between the US and Mexico.

    abstract：:The Paso del Norte region is characterized by its dynamic industries and active agriculture. Throughout the years, urban and agricultural soils from this region have been exposed to xenobiotics, heavy metals, and excess of hydrocarbons. In this study, samples of urban [domestic workshops (DW)] and agricultural-intende...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2018.12.055

    authors： Cota-Ruiz K,López de Los Santos Y,Hernández-Viezcas JA,Delgado-Rios M,Peralta-Videa JR,Gardea-Torresdey JL

    更新日期：2019-02-01 00:00:00

  • Review of the evidence for oceans and human health relationships in Europe: A systematic map.

    abstract：BACKGROUND:Globally, there is increasing scientific evidence of critical links between the oceans and human health, with research into issues such as pollution, harmful algal blooms and nutritional contributions. However, Oceans and Human Health (OHH) remains an emerging discipline. As such these links are poorly recog...

    journal_title：Environment international

    pub_type： 杂志文章,评审

    doi：10.1016/j.envint.2020.106275

    authors： Short RE,Cox DTC,Ling Tan Y,Bethel A,Eales JF,Garside R

    更新日期：2021-01-01 00:00:00

  • Worker exposure to flame retardants in manufacturing, construction and service industries.

    abstract：:Workers in several industries are occupationally exposed to flame retardants. This study characterizes flame retardant exposure for nine industries through air and hand wipe measures for 105 workers. Specifically, we analyzed 24 analytes from three chemical classes: organophosphate flame retardants (OFRs), polybromina...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2019.105349

    authors： Estill CF,Slone J,Mayer A,Chen IC,La Guardia MJ

    更新日期：2020-02-01 00:00:00

  • Respiratory medication sales and urban air pollution in Brussels (2005 to 2011).

    abstract：BACKGROUND:We investigated the associations between daily sales of respiratory medication and air pollutants in the Brussels-Capital Region between 2005 and 2011. METHODS:We used over-dispersed Poisson Generalized Linear Models to regress daily individual reimbursement data of prescribed asthma and COPD medication fro...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2016.06.019

    authors： Casas L,Simons K,Nawrot TS,Brasseur O,Declerck P,Buyl R,Coomans D,Nemery B,Van Nieuwenhuyse A

    更新日期：2016-09-01 00:00:00

  • Phthalate induced oxidative stress and DNA damage in earthworms (Eisenia fetida).

    abstract：:Phthalates (phthalic acid esters) have been widely applied as plasticizers. They are ubiquitous contaminants in soils, thereby posing a threat to human health. In this study, ecotoxicological effects of three typical PAEs (dimethyl phthalate-DMP, di-n-octyl phthalate-DOP and butyl benzyl phthalate-BBP) were investigat...

    journal_title：Environment international

    pub_type： 杂志文章

    doi：10.1016/j.envint.2019.04.074

    authors： Song P,Gao J,Li X,Zhang C,Zhu L,Wang J,Wang J

    更新日期：2019-08-01 00:00:00