Consequences of uterine blood loss caused by various intrauterine contraceptive devices in South American women. World Health Organization Special Programme of Research, Development and Research Training in Human Reproduction.

Abstract:

:Increased menstrual blood loss (MBL) associated with intrauterine device (IUD) use may precipitate or aggravate iron deficiency anaemia, adversely affecting the health of women particularly those from developing countries. Studies were conducted to define the association of MBL and iron status in South American women; to determine the level of MBL induced by IUD use which would result in iron depletion, the length of time for this depletion to occur and, comparing various IUDS, to determine if any currently tested IUDs are suited to long-term use in South American women. A total of 395 women received one of 5 types of IUDs in Santiago, Chile, and Juiz de Fora, Brazil: Lippes Loop, Multiload-250 and Multiload-375 were used in both centres; in Santiago some subjects received the Copper-7 or ProgestasertR devices and in Juiz de Fora, the TCu 200 and the T-Chloroquin IUDs were also tested. MBL and haemoglobin (HGB) were measured for 3 menstrual cycles before insertion, and following insertion, at one, two, four, six, nine, twelve, eighteen and twenty-four months in the majority of cases. Serum ferritin was measured before insertion and at intervals of six months. Mean values of MBL prior to IUD insertion in both centres varied from 21-30 ml. As with previous publications, the use of the Lippes Loop was associated with the greatest increase in MBL which was sustained throughout the 24 months of observation. Women who had one of the two types of Multiload devices inserted also had increased MBL and reduced ferritin for at least 12 months of use. TCu 200 and Copper-7 IUD users had an initial increase in MBL of 1 to 17 ml in the first six months of observation returning to normal levels beyond six months. Serum ferritin levels were lower for one year and then returned to admission values. ProgestasertR users confirmed previous reports of a reduction of 40-50% in MBL and an increase in serum ferritin. Few significant changes in haemoglobin (HGB) concentrations were found. Serum ferritin levels on admission ranged from 7.1 to 16.4 ng/ml in Santiago and from 15.8 to 23.2 ng/ml in Juiz de Fora. Many women were in a marginal state of iron balance as evidenced by lower serum ferritin values. Changes in serum ferritin were very closely related to those in MBL.(ABSTRACT TRUNCATED AT 400 WORDS)

journal_name

Contraception

journal_title

Contraception

authors

Andrade AT,Pizarro E,Shaw ST Jr,Souza JP,Belsey EM,Rowe PJ

doi

10.1016/0010-7824(88)90091-1

subject

Has Abstract

pub_date

1988-07-01 00:00:00

pages

1-18

issue

1

eissn

0010-7824

issn

1879-0518

pii

0010-7824(88)90091-1

journal_volume

38

pub_type

临床试验,杂志文章,随机对照试验
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    authors: Mamo E,Worku M

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  • Preoperative cervical priming by intracervical application of a new sulprostone gel.

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    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Rath W,Dennemark N,Gödicke HD

    更新日期:1985-03-01 00:00:00

  • Observations of scanning electron microscopy detected abnormalities of non-lubricated latex condoms.

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    doi:10.1016/0010-7824(95)00259-6

    authors: Rosenzweig BA,Even A,Budnick LE

    更新日期:1996-01-01 00:00:00

  • Effectiveness of the Yuzpe regimen of emergency contraception by cycle day of intercourse: implications for mechanism of action.

    abstract:OBJECTIVE:The purpose of this study was to provide evidence about the mechanism of action of the Yuzpe method of emergency contraception by examining effectiveness by cycle day of intercourse relative to ovulation. METHODS:Through a literature search, we identified eight studies that present the number of women treate...

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    authors: Trussell J,Ellertson C,Dorflinger L

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  • Medroxyprogesterone acetate and estradiol cypionate injectable suspension (Cyclofem) monthly contraceptive injection: steady-state pharmacokinetics.

    abstract:BACKGROUND:Cyclofem is a combined injectable contraceptive, containing medroxyprogesterone acetate (MPA) and estradiol cypionate. The objective was to characterize the steady-state pharmacokinetics (PK) using tandem liquid chromatography/mass spectrometry and compare these data to a previous PK study of this formulatio...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2012.11.010

    authors: Thurman A,Kimble T,Hall P,Schwartz JL,Archer DF

    更新日期:2013-06-01 00:00:00

  • Phase I/II pharmacokinetic and pharmacodynamic evaluation of two levonorgestrel-only contraceptive patches in a multicenter randomized trial.

    abstract:OBJECTIVES:To evaluate the pharmacokinetic and pharmacodynamic effects of two novel levonorgestrel (LNG)-only contraceptive patches. STUDY DESIGN:This multi-center Phase I/II trial randomized participants to use a 7-day transdermal patch designed to deliver a 40 mcg or 75 mcg daily LNG dose for 11 consecutive weeks; r...

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    pub_type: 杂志文章

    doi:10.1016/j.contraception.2018.04.007

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    更新日期:2018-04-18 00:00:00

  • Progestogen-only contraceptive use among women with sickle cell anemia: a systematic review.

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    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2005.08.010

    authors: Legardy JK,Curtis KM

    更新日期:2006-02-01 00:00:00

  • Comparison of remote and in-clinic follow-up after methotrexate/misoprostol abortion.

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    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.contraception.2015.05.013

    authors: Dunn S,Panjwani D,Gupta M,Meaney C,Morgan R,Feuerstein E

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  • Acceptability of the community-level provision of Sayana® Press by medical and nursing students in Kinshasa, Democratic Republic of the Congo.

    abstract:OBJECTIVES:The objectives were to assess acceptors' attitudes toward Sayana® Press as a method and toward the mechanism of community-based distribution by medical and nursing (M/N) students, known locally as "DBCs," in Kinshasa, Democratic Republic of the Congo, and to evaluate the experience of these DBCs. STUDY DESI...

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    pub_type: 杂志文章

    doi:10.1016/j.contraception.2017.05.014

    authors: Bertrand JT,Makani PB,Hernandez J,Akilimali P,Mukengeshayi B,Babazadeh S,Binanga A

    更新日期:2017-09-01 00:00:00

  • Fertility considerations and attitudes about family planning among women with cystic fibrosis.

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    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2019.05.005

    authors: Traxler SA,Chavez V,Hadjiliadis D,Shea JA,Mollen C,Schreiber CA

    更新日期:2019-09-01 00:00:00

  • Clinicians' perceptions and provision of hormonal contraceptives for HIV-positive and at-risk women in Southern Africa: an original research article.

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    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2014.04.010

    authors: Blanchard K,Chipato T,Ramjee G,Nhemachena T,Harper CC,Provider Study Writing Comittee.

    更新日期:2014-10-01 00:00:00

  • Use of a radioreceptor test for HCG in women practicing contraception.

    abstract::The importance of a simple, rapid and highly sensitive test for the diagnosis of early pregnancy cannot be overemphasized. In the present times when newer delivery systems of contraceptive agents and menstrual regulation procedures are increasingly used for fertility regulation, it is inevitable that confirmation of e...

    journal_title:Contraception

    pub_type: 杂志文章

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    journal_title:Contraception

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.contraception.2016.02.004

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    更新日期:2016-06-01 00:00:00

  • The effects of oral contraceptives on androgen levels and their relevance to premenstrual mood and sexual interest: a comparison of two triphasic formulations containing norgestimate and either 35 or 25 microg of ethinyl estradiol.

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    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2007.04.002

    authors: Greco T,Graham CA,Bancroft J,Tanner A,Doll HA

    更新日期:2007-07-01 00:00:00

  • Lowering oral contraceptive norethindrone dose increases estrogen and progesterone receptor levels with no reduction in proliferation of breast epithelium: a randomized trial.

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    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2011.12.015

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    更新日期:2012-09-01 00:00:00

  • TSPY4 is a novel sperm-specific biomarker of semen exposure in human cervicovaginal fluids; potential use in HIV prevention and contraception studies.

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    pub_type: 杂志文章

    doi:10.1016/j.contraception.2012.11.022

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  • Grief after second-trimester termination for fetal anomaly: a qualitative study.

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    pub_type: 杂志文章

    doi:10.1016/j.contraception.2014.11.015

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  • The effect of some beta -adrenergic blocking agents on ovulation in rabbits.

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    pub_type: 杂志文章

    doi:10.1016/s0010-7824(75)80036-9

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    更新日期:1975-07-01 00:00:00

  • Effects of three types of combined O.C. pills on blood coagulation, fibrinolysis and platelet function.

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    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(89)90116-9

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    更新日期:1989-04-01 00:00:00

  • Ovarian function, bleeding control and serum lipoproteins in women using contraceptive vaginal rings releasing five different progestins.

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    journal_title:Contraception

    pub_type: 杂志文章

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    更新日期:1983-10-01 00:00:00

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    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2014.07.005

    authors: Nothnagle M,Radlinski H,Magee SR,Allen RH

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  • Expression of Hsp70-2 in rhesus monkey testis during germ cell apoptosis induced by testosterone undecanoate.

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    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(02)00357-8

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    更新日期:2002-11-01 00:00:00

  • Choice of the levonorgestrel intrauterine device, etonogestrel implant or depot medroxyprogesterone acetate for contraception after aspiration abortion.

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    pub_type: 杂志文章

    doi:10.1016/j.contraception.2015.06.013

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    pub_type: 杂志文章

    doi:10.1016/j.contraception.2011.06.006

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    pub_type: 杂志文章

    doi:10.1016/j.contraception.2017.12.008

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  • Seminal fructose in normal and infertile men.

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    pub_type: 杂志文章

    doi:10.1016/0010-7824(89)90062-0

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    journal_title:Contraception

    pub_type: 杂志文章,多中心研究

    doi:10.1016/0010-7824(94)00007-j

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    pub_type: 杂志文章

    doi:10.1016/0010-7824(83)90073-2

    authors: Fotherby K,Towobola O,Muggeridge J,Elder MG

    更新日期:1983-11-01 00:00:00

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    journal_title:Contraception

    pub_type: 杂志文章,实务指引

    doi:10.1016/j.contraception.2013.11.001

    authors: Fox MC,Krajewski CM

    更新日期:2014-02-01 00:00:00

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    abstract::The pharmacology and clinical assessment of existing first generation once-a-month combined injectable contraceptives, mainly Deladroxate and Chinese Injectable No. 1, are reviewed. Although these two types of monthly injectables have been used in some million women in China and Latin America, Deladroxate needs indept...

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    pub_type: 杂志文章,评审

    doi:10.1016/0010-7824(94)90033-7

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    更新日期:1994-04-01 00:00:00