Adult-derived pluripotent stem cells.


:The global incidence of spinal cord injury (SCI) is 15-40 cases per million people, with the socioeconomic and healthcare costs amounting to nearly $10 billion per annum in the USA alone. Despite substantial advances in medical care and surgical technology, many patients with SCI still experience significant long-term neurologic disability. Cellular transplantation offers a promising therapy to address the multifactorial nature of SCI in both the subacute and chronic phase of the injury to promote central nervous system repair and regeneration and to augment existing therapies. Adult-derived stem cells are the least ethically challenging stem cells but, until recently, a major hurdle has been inducing pluripotency to generate the required neural lineages. Improved generation and transfection techniques, combined with positive experimental outcomes in SCI models, suggest that adult-derived induced pluripotent stem cells could be a genuine alternative to embryonic stem cells for clinical treatments. For translation from bench to bedside, the efficacy of induced pluripotent stem cell-derived neural stem and progenitor cells in suitable SCI models needs to be validated further and backed up with rigorous early-stage clinical trials.


World Neurosurg


World neurosurgery


Faulkner SD,Vawda R,Fehlings MG




Has Abstract


2014-09-01 00:00:00














  • Risk Factors for Chronic Subdural Hematoma Recurrence Identified Using Quantitative Computed Tomography Analysis of Hematoma Volume and Density.

    abstract:OBJECTIVE:Chronic subdural hematoma (CSDH), a common condition in elderly patients, presents a therapeutic challenge with recurrence rates of 33%. We aimed to identify specific prognostic factors for recurrence using quantitative analysis of hematoma volume and density. METHODS:We retrospectively reviewed radiographic...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Stavrinou P,Katsigiannis S,Lee JH,Hamisch C,Krischek B,Mpotsaris A,Timmer M,Goldbrunner R

    更新日期:2017-03-01 00:00:00

  • Malignant peripheral nerve sheath tumor of the abducens nerve and a review of the literature.

    abstract:BACKGROUND:Malignant peripheral nerve sheath tumors are rare, and intracranial occurrences are even more rare. Treatment strategies have varied widely. This article reports the first case of a malignant peripheral nerve sheath tumor of the abducens nerve and provides a literature review that includes 61 cases of intrac...

    journal_title:World neurosurgery

    pub_type: 杂志文章,评审


    authors: Voorhies J,Hattab EM,Cohen-Gadol AA

    更新日期:2013-11-01 00:00:00

  • Radiologic Characteristics and High Risk of Seizures in Infants with Ruptured Intracranial Aneurysms: Case Report and Review of the Literature.

    abstract:OBJECTIVE:To evaluate the parameters related to the high risk of preoperative seizures in infants (1 year or younger) with ruptured intracranial aneurysms. METHODS:Infants with ruptured intracranial aneurysms treated at our institution from January 2012 to January 2018 were retrospectively analyzed. Seventeen similar ...

    journal_title:World neurosurgery

    pub_type: 杂志文章,评审


    authors: Chen R,Ren Y,Zhang S,You C,Liu Y

    更新日期:2018-10-01 00:00:00

  • The Introduction of Innovations in Neurovascular Care: Patient Selection and Randomized Allocation.

    abstract::Most neurovascular innovations have been introduced by using case series followed by observational studies. A better approach would be a pragmatic randomized trial. Two important aspects of trial design, patient selection and randomized allocation, remain poorly understood. We discuss the role trial methodology can pl...

    journal_title:World neurosurgery

    pub_type: 杂志文章,评审


    authors: Fahed R,Darsaut TE,Raymond J

    更新日期:2018-10-01 00:00:00

  • Use of 3-Dimensional Printing Technology in Complex Spine Surgeries.

    abstract:BACKGROUND:Medical implications of 3-dimensional (3D) printing technology have evolved and are increasingly used. Surgical spine oncology involves at times complex resection using various surgical approaches and unique spinal reconstruction. As high general complication rates, including hardware failure, are reported, ...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Lador R,Regev G,Salame K,Khashan M,Lidar Z

    更新日期:2020-01-01 00:00:00

  • Patient with Epilepsy Caused by the Spontaneous Rupture of an Intracerebral Dermoid Cyst.

    abstract:BACKGROUND:This is a rare case of a patient presenting with epileptic seizures and headaches who was diagnosed with spontaneous intracerebral dermoid cyst rupture via radiographic imagery, and rupture was confirmed via a pathology report. CASE DESCRIPTION:We report the case of a woman aged 26 years who presented with ...

    journal_title:World neurosurgery



    authors: Xin WQ,Lei Y,Chen D,Chen ZJ,Yang XY,Zhang N

    更新日期:2020-04-01 00:00:00

  • Thirty-Day Perioperative Adverse Outcomes After Peripheral Nerve Surgery: An Analysis of 2351 Patients in the American College of Surgeons National Surgical Quality Improvement Program Database.

    abstract:BACKGROUND:Because peripheral nerve surgery has become more common in recent years, the pressure to increase this procedure's health care safety and cost-effectiveness has increased. Given our limited understanding, we evaluated prospectively identified and randomly sampled patients who underwent peripheral nerve surge...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Hu K,Zhang T,Hutter M,Xu W,Williams Z

    更新日期:2016-10-01 00:00:00

  • Clinical characteristics, immunohistochemistry, and outcomes of 77 patients with skull base chordomas.

    abstract:OBJECTIVE:To analyze the clinical characteristics, immunohistochemistry, and treatment outcomes for skull base chordomas and the correlation between extent of resection/pathology type and outcomes. METHODS:The clinical materials of 77 consecutive patients with skull base chordomas were analyzed retrospectively. Follow...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Ouyang T,Zhang N,Zhang Y,Jiao J,Ren J,Huang T,Chen J

    更新日期:2014-05-01 00:00:00

  • Flat Panel Detector Computed Tomography-Guided Placement of External Ventricular Drains Using the BrainLAB Headband and Precalibrated Disposable Stylet Instrument: A Cadaveric Feasibility Study.

    abstract:BACKGROUND:The standard freehand method for the insertion of external ventricular drains (EVDs) is associated with high rates of incorrect placement. Use of neuronavigation has been shown to reduce the rates of inaccurately positioned EVDs. We present a novel neuronavigation-based approach for EVD placement using flat ...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Feulner J,Lang S,Buder T,Struffert T,Buchfelder M,Brandner S

    更新日期:2018-07-01 00:00:00

  • Principles of Remediation for the Struggling Neurosurgery Resident.

    abstract:BACKGROUND:When resident physicians fail to demonstrate appropriate milestone competencies early in their neurologic surgery residency, a plan of remediation is necessary. METHODS:Once any psychologic, physical, or behavioral causes of identified knowledge or psychomotor deficiencies have been identified and addressed...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Jensen RL,Kestle JRW,Brockmeyer DL,Couldwell WT

    更新日期:2020-11-27 00:00:00

  • Withstand pressure of a simple fibrin glue sealant: experimental study of mimicked sellar reconstruction in extended transsphenoidal surgery.

    abstract:BACKGROUND:To examine the strength and tolerance of the fibrin glue sealant in a situation of extended transsphenoidal surgery. The withstand pressure of fibrin glue sealant was measured using a simple sellar reconstruction model. METHODS:A 15-mm diameter hole at the bottom of a 51-cm high cylinder was covered with a ...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Oshino S,Saitoh Y,Yoshimine T

    更新日期:2010-06-01 00:00:00

  • Direct Bypass Versus Indirect Bypass in Adult Moyamoya Angiopathy with Symptoms or Hemodynamic Instability: A Meta-analysis of Comparative Studies.

    abstract:BACKGROUND:It remains controversial which bypass methods are optimal for treating adult moyamoya angiopathy patients. This study aimed to analyze the literature about whether different bypass methods affect differently outcome results of adult moyamoya patients with symptoms or hemodynamic instability. METHODS:A syste...

    journal_title:World neurosurgery

    pub_type: 杂志文章,meta分析,评审


    authors: Kim H,Jang DK,Han YM,Sung JH,Park IS,Lee KS,Yang JH,Huh PW,Park YS,Kim DS,Han KD

    更新日期:2016-10-01 00:00:00

  • The Tethered Effect of Vestibular Schwannoma Tumor Shrinkage Following Stereotactic Radiosurgery in Secondary Trigeminal Neuralgia.

    abstract:BACKGROUND:Compression of the trigeminal nerve by vessels and tumors causes trigeminal neuralgia. However, a tethering effect, provoking an abnormal root-stretching force, has been previously reported to play a role in trigeminal nerve hyperexcitability. We report 2 patients with vestibular schwannomas treated by stere...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Izumi M,Higuchi Y,Yakufujiang M,Motoshima T,Horiguchi K,Aoyagi K,Nagano O,Serizawa T,Iwadate Y,Yamakami I

    更新日期:2019-03-01 00:00:00

  • Intracranial Arterial Dissection Mimicking a Saccular Aneurysm: Clinical Image.

    abstract::This report portrays our pitfall in the initial diagnosis of an intracranial arterial dissection that we misinterpreted as a saccular aneurysm. Intracranial arterial dissections presenting with convexity subarachnoid hemorrhage are rare, thus being easily mistaken with mild traumatic head injuries and therefore preven...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Rodríguez-Hernández A,Torné R,Arikan F

    更新日期:2017-02-01 00:00:00

  • Alignment Risk Factors for Proximal Junctional Kyphosis and the Effect of Lower Thoracic Junctional Tethers for Adult Spinal Deformity.

    abstract:OBJECTIVE:The aims of this retrospective cohort study were to 1) identify new alignment risk factors for proximal junctional kyphosis (PJK) in adult spinal deformity (ASD) patients with lower thoracic upper instrumented vertebra (UIV) and 2) determine the effect of junctional tethers on PJK and UIV alignment. METHODS:...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Buell TJ,Chen CJ,Quinn JC,Buchholz AL,Mazur MD,Mullin JP,Nguyen JH,Taylor DG,Bess S,Line BG,Ames CP,Schwab FJ,Lafage V,Shaffrey CI,Smith JS

    更新日期:2019-01-01 00:00:00

  • Bibliometric Analysis of the Top 100 Influential Studies on Carotid Artery Stenting.

    abstract:BACKGROUND:Artery stenting is an effective therapy for carotid artery stenosis to prevent ischemic stroke. We aimed to identify and analyze the 100 top-cited reports on carotid artery stenting (CAS) to review the achievements and developments in this field. METHODS:The Web of Knowledge database was searched from its i...

    journal_title:World neurosurgery

    pub_type: 杂志文章,评审


    authors: Cheng W,Kang Q,Xiao Q

    更新日期:2019-02-01 00:00:00

  • Transforaminal Percutaneous Endoscopic Decompression for Lower Thoracic Spinal Stenosis.

    abstract:OBJECTIVE:To explore the effect and safety of transforaminal percutaneous endoscopic decompression for lower thoracic spinal stenosis. METHODS:We reviewed 6 patients receiving transforaminal percutaneous endoscopic thoracic decompression for sympathetic symptoms in the lower extremities. Pre- and postoperative Frankel...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Guo C,Zhu D,Kong Q,Zhang L,Wang Y,Yang J,Yan Y,Wu H,Peng Z

    更新日期:2019-08-01 00:00:00

  • Intervertebral Displacement of the Thoracic Spine with and without Loading: Radiographic and in Vitro Measurements.

    abstract:BACKGROUND:We are developing an intradural approach to spinal cord stimulation, where the thin electrode array is affixed stably to the underside of the thoracic spinal dura mater without leakage of cerebrospinal fluid. As part of the design and testing process, we sought to evaluate the potential risk of inadvertent c...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Seaman SC,Zanaty M,Holland MT,Gillies GT,Howard MA 3rd,Yamaguchi S

    更新日期:2020-06-01 00:00:00

  • Bony Lateral Recess Stenosis and Other Radiographic Predictors of Failed Indirect Decompression via Extreme Lateral Interbody Fusion: Multi-Institutional Analysis of 101 Consecutive Spinal Levels.

    abstract:OBJECTIVE:Although extreme lateral interbody fusion (XLIF) largely provides successful indirect decompression, some patients have recurrent same-level pain and functional disability. Identifying risk factors for this failure would facilitate better patient selection and improve outcomes. The aim of this study is to ide...

    journal_title:World neurosurgery

    pub_type: 杂志文章,多中心研究


    authors: Wang TY,Nayar G,Brown CR,Pimenta L,Karikari IO,Isaacs RE

    更新日期:2017-10-01 00:00:00

  • Is Extended Lesionectomy Needed for Patients with Cerebral Cavernous Malformations Presenting with Epilepsy? A Meta-Analysis.

    abstract:OBJECTIVE:To determine whether extended lesionectomy is needed for patients with cerebral cavernous malformations presenting with epilepsy as compared with lesionectomy. METHODS:A literature search of PubMed, Embase, Web of Science, Clinical Trials and Cochrane Central Register of Controlled Trials was performed for p...

    journal_title:World neurosurgery

    pub_type: 杂志文章,meta分析


    authors: Shang-Guan HC,Wu ZY,Yao PS,Chen GR,Zheng SF,Kang DZ

    更新日期:2018-12-01 00:00:00

  • Assessment of Myelopathy in Cervical Ossification of the Posterior Longitudinal Ligament by Magnetic Resonance Imaging-Assisted 3-Dimensional Measurement.

    abstract:BACKGROUND:Ossification of the posterior longitudinal ligament (OPLL) is a 3-dimensional (3D) disease that causes cervical myelopathy. The conventional 2-dimensional (2D) measurement of OPLL has limitations in estimating cord compression and myelopathy. In this study, we attempted to use 3D computed tomography (CT) and...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Wang Z,Sun Y,Tang Y,Yuan B,Zhou S,Chen X,Jia L

    更新日期:2018-07-01 00:00:00

  • Effects of Curcumin on Bone Loss and Biochemical Markers of Bone Turnover in Patients with Spinal Cord Injury.

    abstract:BACKGROUND:Osteoporosis is one of the most common problems of patients with spinal cord injuries (SCIs). The current study aimed to evaluate the antiosteoporotic effects of curcumin on densitometry parameters and biomarkers of bone turnovers among patients with SCI. MATERIALS AND METHODS:The current controlled clinica...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Hatefi M,Ahmadi MRH,Rahmani A,Dastjerdi MM,Asadollahi K

    更新日期:2018-06-01 00:00:00

  • Electrocardiogram-Triggered Angiography Non-Contrast-Enhanced (TRANCE) Imaging to Assess Access Route Before Diagnostic Cerebral Angiography.

    abstract:BACKGROUND:Electrocardiogram (ECG)-triggered angiography non-contrast-enhanced (TRANCE) imaging is useful for investigating peripheral vessel diseases; however, its efficacy for access route assessment in cerebral angiography has yet to be reported. Therefore we aimed to evaluate the efficacy of TRANCE imaging in the a...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Osanai T,Kazumata K,Kobayashi S,Fujima N,Kurisu K,Shimoda Y,Houkin K

    更新日期:2018-11-01 00:00:00

  • Identification of Preoperative Language Tracts for Intrinsic Frontotemporal Diseases: A Pilot Reconstruction Algorithm in a Middle-Income Country.

    abstract:OBJECTIVE:Diffusion tensor imaging (DTI) tractography provides useful information that can be used to optimize surgical planning and help avoid injury during subcortical dissection of eloquent tracts. The objective is to provide a safe, timely, and affordable algorithm for preoperative DTI language reconstruction for i...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Ordóñez-Rubiano EG,Valderrama-Arias FA,Forbes JA,Johnson JM,Younus I,Marín-Muñoz JH,Sánchez-Montaño M,Angulo DA,Cifuentes-Lobelo HA,Cortes-Lozano W,Pedraza-Ciro MC,Bello-Dávila ML,Patiño-Gómez JG,Ordóñez-Mora EG

    更新日期:2019-05-01 00:00:00

  • Feasibility of Smart Metal Artifact Reduction Algorithm on Computed Tomography Angiography for Clipping of Recurrent Aneurysms After Coil Embolization.

    abstract:BACKGROUND:The number of patients with a history of clipping of recurrent aneurysms after coil embolization has increased. The aim of this article was to report the feasibility of CT angiography using a commercial metal artifact reduction algorithm (Smart Metal Artifact Reduction [MAR]) for patients who underwent clipp...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Kuroda H,Toyota S,Kumagai T,Iwata T,Kobayashi M,Mori K,Taki T

    更新日期:2019-07-01 00:00:00

  • COVID-19 Impact on Neurosurgical Practice: Lockdown Attitude and Experience of a European Academic Center.

    abstract:BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic is an unprecedented challenge. Different models of reorganization have been described aiming to preserve resources and ensure optimal medical care. Limited clinical neurosurgical experience with patients with COVID-19 has been reported. We share organizational...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Lubansu A,Assamadi M,Barrit S,Dembour V,Yao G,El Hadwe S,De Witte O

    更新日期:2020-12-01 00:00:00

  • Implementation of Intraoperative Computed Tomography for Deep Brain Stimulation: Pitfalls and Optimization of Workflow, Accuracy, and Radiation Exposure.

    abstract:OBJECTIVE:Deep brain stimulation (DBS) is an effective treatment for movement disorders. Stereotactic electrode placement can be guided by intraoperative imaging, which also allows for immediate intraoperative quality control. This article is about implementation and refining a workflow applying intraoperative computed...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Carl B,Bopp M,Gjorgjevski M,Oehrn C,Timmermann L,Nimsky C

    更新日期:2018-12-27 00:00:00

  • Is the Thoracolumbar AOSpine Injury Score Superior to the Thoracolumbar Injury Classification and Severity Score for Guiding the Treatment Strategy of Thoracolumbar Spine Injuries?

    abstract:OBJECTIVE:To determine whether Thoracolumbar Injury Classification and Severity Score (TLICS) and the Thoracolumbar AOSpine Injury Score (TL AOSIS) have any superiority to each other in terms of the reliability of their recommendations for guiding the treatment strategy of thoracolumbar spine injuries. METHODS:A total...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: An Z,Zhu Y,Wang G,Wei H,Dong L

    更新日期:2020-05-01 00:00:00

  • Intraparenchymal Meningioma in the Basal Ganglia.

    abstract::We herein report a rare case of intraparenchymal meningioma in the right basal ganglia. The tumor was located incidentally and preoperatively diagnosed as malignant glioma. Preoperative magnetic resonance imaging revealed that the tumor involved the lenticulostriate artery, and open biopsy was performed to avoid posto...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Matsuda R,Shida Y,Nakamura M

    更新日期:2019-08-01 00:00:00

  • Trepanation to Treat a Head Wound: A Case of Neurosurgery from 13th-Century Tuscany.

    abstract::During the archaeological excavations conducted in the 13th century cemetery of the Church of Sant'Agostino in Poggibonsi (Tuscany, Italy), a skull with evidence of neurosurgical intervention was brought to light. The skull, belonging to an adult male, shows two traumatic lesions produced by bladed instruments. The fi...

    journal_title:World neurosurgery

    pub_type: 历史文章,杂志文章,评审


    authors: Riccomi G,Fornaciari G,Vitiello A,Bini A,Caramella D,Giuffra V

    更新日期:2017-08-01 00:00:00