Abstract：
:The global incidence of spinal cord injury (SCI) is 15-40 cases per million people, with the socioeconomic and healthcare costs amounting to nearly $10 billion per annum in the USA alone. Despite substantial advances in medical care and surgical technology, many patients with SCI still experience significant long-term neurologic disability. Cellular transplantation offers a promising therapy to address the multifactorial nature of SCI in both the subacute and chronic phase of the injury to promote central nervous system repair and regeneration and to augment existing therapies. Adult-derived stem cells are the least ethically challenging stem cells but, until recently, a major hurdle has been inducing pluripotency to generate the required neural lineages. Improved generation and transfection techniques, combined with positive experimental outcomes in SCI models, suggest that adult-derived induced pluripotent stem cells could be a genuine alternative to embryonic stem cells for clinical treatments. For translation from bench to bedside, the efficacy of induced pluripotent stem cell-derived neural stem and progenitor cells in suitable SCI models needs to be validated further and backed up with rigorous early-stage clinical trials.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Faulkner SD,Vawda R,Fehlings MGdoi
10.1016/j.wneu.2013.08.004subject
Has Abstractpub_date
2014-09-01 00:00:00pages
500-8issue
3-4eissn
1878-8750issn
1878-8769pii
S1878-8750(13)00965-0journal_volume
82pub_type
杂志文章,评审abstract：:Spinal cord stimulation is a safe method for treating chronic pain syndromes. Spinal cord stimulators can be placed either surgically by creating a laminectomy defect for paddle leads or percutaneously by inserting electrodes. They are usually not associated with major complications. There have been several reports of...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.05.152
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Intraoperative neuromonitoring (ION) signal changes during spine surgery may portend a potentially catastrophic neurologic injury that, if identified and addressed expediently, may allow the surgeon to take correction actively and prevent permanent neurologic injury. CASE DESCRIPTION:We report a case of tra...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.06.116
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:Sclerosteosis (OMIM 269500) is a progressive, autosomal recessive, sclerosing bone disorder with a well defined phenotype. This phenotype is correlated with a deficiency in the protein product sclerostin, leading to bony overgrowth from the loss of inhibition of osteocyte function. Calvarial overgrowth can l...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2012.11.061
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:Neurosurgical educators strive to identify the best applicants, yet formal study of resident selection has proved difficult. We conducted a systematic review to answer the following question: What objective and subjective preresidency factors predict resident success? METHODS:PubMed, ProQuest, Embase, and t...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.11.078
更新日期：2018-02-01 00:00:00
abstract：:Clinical neurosurgery is a complex specialty with multiple participants, including a variety of providers, patients, family members, and administrators, who interact in complex fashions. Modern-day patient care requires near-constant team communication of vital, detailed clinical information; any breakdown in this pro...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.08.134
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:Patients with large and giant intracranial aneurysms (IAs) can experience neurological deterioration within 6 months after successful flow diverter (FD) placement. The purpose of the present study was to assess whether the occurrence of neurological deterioration can be linked to IA expansion within 6 months ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.08.169
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:We describe a rare case of a sphenoid sinus myxoma that was resected via an endoscopic endonasal skull base approach. We review the literature regarding these rare tumors of the paranasal sinuses. CASE DESCRIPTION:A 72-year-old woman was diagnosed with an incidental sphenoid sinus tumor and left sphenoid wi...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.04.019
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVE:Percutaneous endoscopic lumbar discectomy is an effective way to treat lumbar disc herniation. Traditional preoperative planning based on a 2-dimensional method by magnetic resonance/computed tomography may cause inaccuracy of puncture during surgery. We used virtual reality to stimulate a surgery environment...
journal_title：World neurosurgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.wneu.2018.08.082
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:The current study is an external validation of 4 scoring models proposed in the literature for predicting ventriculoperitoneal shunt insertion after aneurysmal subarachnoid hemorrhage (aSAH) using retrospective patient data from Sheffield Teaching Hospital (STH). METHODS:Data were collected on various demog...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.11.146
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:Risk control of thromboembolic complications (TECs) during stent-assisted coil embolization (SACE) for unruptured intracranial aneurysms (UIAs) is crucial for satisfactory treatment outcomes. We retrospectively evaluated the data from our cohort of SACE for UIAs to analyze the role of anatomical, clinical, an...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.10.179
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:The ideal treatment method for cranial arachnoid cysts stills controversial, each of endoscopic and microscopic techniques has its pros and cons. METHODS:We described cystocisternostomy technique for arachnoid cysts through fenestration medial to the edge of tentorium through lateral pontomesencephalic memb...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.12.108
更新日期：2020-12-29 00:00:00
abstract：:Meningiomas are mostly benign intradural tumors. Concerning the spine, some of them can extend outside the canal or even develop extradurally but their primary attach is often located in the vertebral canal. Here we present the case of an exceptional purely intraforaminal meningioma mimicking a neurogenic tumor, invol...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.10.006
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Incomplete penetration of a burr hole sometimes occurs when performing a craniotomy in elderly patients due to osteoporosis. Completion of the burr hole takes more time and may sometimes cause tearing of the dura mater. We have introduced a small bone piece method that can easily and reliably recover an inco...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.06.080
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:The use of magnetic resonance imaging (MRI)-guided ablation methods, such as laser interstitial thermal therapy and MRI-guided radiofrequency thermocoagulation (RF-TC), poses a risk of mistreatment in patients with nonepileptic hypothalamic hamartoma (HH). Using stereoelectroencephalography (SEEG)-guided RF-...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.03.148
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Metastatic tumors involving the pituitary gland are very rare, with only few cases reported so far in the literature. CASE DESCRIPTION:We report a case of a man who presented with an extremely vascular hemorrhagic pituitary metastasis as the first manifestation of renal cell carcinoma. The patient was succe...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2012.09.006
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:Cerebrospinal fluid (CSF)-containing cysts at the level of the choroidal fissure are rare embryological entities infrequently described in the literature because of their benign nature. On the occasion of a case series, we present an overview of the literature and discuss anatomical and embryological locatio...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2010.12.056
更新日期：2011-05-01 00:00:00
abstract：:Rare anomalous courses of vertebral arteries in the craniovertebral junction may compress the spinal cord causing myelopathy. We report here the severest form of this pathologic condition successfully treated with transposition of bilateral vertebral artery using Gore-Tex tapes. A 73-year-old man presented with progre...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.10.050
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Spinal metastatic disease compromises the quality of life and prognosis of the patients. Prognosis is an important factor for the decision-making process and needs to be precise in order to adjust the intensity of therapy. The Tokuhashi score is a universal instrument to determine the prognosis. The objectiv...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.11.033
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:Neuroendoscopy is increasingly being used in the management of intraventricular brain tumors. The role of endoscopy in diagnostic biopsy is well established. Expansion of these techniques may allow for definitive resection of intraventricular tumors. We report the feasibility and outcomes of endoscopic resect...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.11.052
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Several studies have been conducted to identify the pathogenesis of and manage disk degeneration. To further this research, reliable animal models of disk degeneration are required. In the present study, a percutaneous technique is used to create a rabbit model of degenerative disk disease, and the reproduci...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.03.066
更新日期：2015-08-01 00:00:00
abstract：:We present an uncommon case of holocord, "rosary bead-like," multiloculated syringomyelia consistent with a fourth ventricle outlet obstruction in a 2-month-old infant who was previously shunted for posthemorrhagic hydrocephalus of prematurity. The shunt malfunction resulted in a syringomyelia because of the simultane...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2020.04.158
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Anatomic hemispherectomy is an effective surgical treatment for patients with hemispherical intractable epilepsy. Different degrees of brain shifting have been observed, but whether these shifts can predict motor function recovery is unknown. The aim of this study was to analyze the correlation between brain...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.07.024
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:Flow diversion has emerged as a promising strategy for management of intracranial aneurysms. The purpose of this study was to determine whether treatment of large and giant aneurysms with the pipeline embolization device (PED) is more economical than traditional embolization strategies. METHODS:We identified...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2013.02.089
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:Magnetic resonance imaging (MRI) plays an important role in the assessment of spinal cord status for cervical spondylotic myelopathy (CSM). Diffusion tensor imaging (DTI) also is a novel investigation tool with good sensitivity to detect changes in CSM, but it is not routinely used in spinal cord evaluation....
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.07.067
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:To investigate correlations between radiologic measurements and clinical outcomes in patients with basilar invagination (BI). METHODS:The medical records and radiologic data of 46 patients (27 women) who had undergone posterior atlantoaxial fusion or occipitocervical fusion for BI from January 2010 to June 2...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.07.080
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:Hydrogen peroxide (H2O2) solution is commonly used to irrigate wounds because of its hemostatic and antiseptic properties. Previous studies suggest that H2O2 can result in toxicity to keratinocytes and fibroblasts, but complications after H2O2 application, including oxygen embolism, which is one of the most ...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2020.03.035
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Intracranial extraskeletal mesenchymal chondrosarcomas (MCSs) are rare tumors accounting for <0.16% of intracranial tumors. They are usually described as occurring in the age group of 20-30 years and are commonly found in the frontoparietal region arising from the falx and surrounding dura. We describe 3 cas...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.08.049
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:The present study evaluated the relationships among perioperative hyperchloremic metabolic acidosis (HCA), hyperchloremia, and postoperative acute kidney injury (AKI) in patients who had undergone craniotomy for intracranial hemorrhage (ICH). METHODS:The present retrospective cohort study included adult pat...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.02.015
更新日期：2019-05-01 00:00:00
abstract：OBJECTIVE:The interlaminar fusion combination involving C1-C2 screwing fixation is one of the most effective techniques for atlantoaxial dislocation or subluxation, and the bone graft is usually stabilized by wiring constructs. However, some adverse events were reported during the insertion of sublaminar wiring, such a...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.03.023
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVE:To report about the diagnosis, surgical treatment, and postoperative management of pharyngo-esophageal perforations (PEPs) after anterior cervical spine (ACS) surgery in 17 patients. METHODS:A retrospective multicenter case series of patients surgically treated for PEP after ACS surgery was performed. Data r...
journal_title：World neurosurgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.wneu.2020.04.040
更新日期：2020-07-01 00:00:00
