In vitro anesthetic washin and washout via bubble oxygenators: influence of anesthetic solubility and rates of carrier gas inflow and pump blood flow.


:The uptake and elimination of volatile anesthetic agents administered to patients under conditions of hemodilution and hypothermia during cardiopulmonary bypass have not been determined. To define the limitations imposed by oxygenators, we defined washin and washout curves for volatile anesthetic agents administered to bubble oxygenators primed with diluted blood (without connection to a patient). There was rapid equilibration of anesthetic partial pressure between delivered gas and blood (85-90% within 16 minutes). Increasing the gas inflow to the oxygenator from 3 to 12 L/min hastened washin and washout slightly, while increasing the pump blood flow from 3 to 5 L/min had no effect. Rates of washin and washout of anesthetics differed as a function of their blood/gas solubilities: enflurane greater than isoflurane greater than halothane during washin; isoflurane greater than enflurane greater than halothane during washout. However, these differences were small. Oxygenator exhaust partial pressures of anesthetic correlated with simultaneously obtained blood partial pressures, suggesting that monitoring exhaust gas may be useful clinically.


Anesth Analg


Anesthesia and analgesia


Nussmeier NA,Moskowitz GJ,Weiskopf RB,Cohen NH,Fisher DM,Eger EI 2nd


Has Abstract


1988-10-01 00:00:00












  • Clinical pharmacokinetics of carbonated local anesthetics. II: Interscalene brachial block model.

    abstract::A double-blind comparison of 1.1% lidocaine carbonate and 1.0% lidocaine hydrochloride was carried out in 30 healthy adult patients undergoing upper-extremity surgery under interscalene brachial plexus block. Epinephrine (1:200,000) was added to both solutions just before injection. As compared to lidocaine hydrochlor...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Sukhani R,Winnie AP

    更新日期:1987-12-01 00:00:00

  • Quantification of Fibrinolysis Using Velocity Curves Measured with Thromboelastometry in Children with Congenital Heart Disease.

    abstract:BACKGROUND:In this pilot study, we hypothesized that velocity parameters obtained from changes in clot amplitude (A) and clot elasticity (E) measured with thromboelastometry (ROTEM, Tem International GmbH, Munich, Germany) could improve detection of fibrinolysis in whole blood obtained from children undergoing surgery ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Faraoni D,Van der Linden P,Ducloy-Bouthors AS,Goobie SM,DiNardo JA,Nielsen VG

    更新日期:2015-08-01 00:00:00

  • Recent advances in and limitations of cardiac output monitoring by means of electrical impedance tomography.

    abstract:BACKGROUND:Currently, the monitoring of cardiac output (CO) and stroke volume (SV) is mainly performed using invasive techniques. Therefore, performing CO monitoring noninvasively by means of electrical impedance tomography (EIT) would be advantageous for intensive care. Our hypothesis was that, by means of EIT, it is ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Pikkemaat R,Lundin S,Stenqvist O,Hilgers RD,Leonhardt S

    更新日期:2014-07-01 00:00:00

  • The Role of MicroRNAs in Acute Respiratory Distress Syndrome and Sepsis, From Targets to Therapies: A Narrative Review.

    abstract::Acute respiratory distress syndrome (ARDS) is a significant cause of morbidity and mortality in the intensive care unit (ICU) and is characterized by lung epithelial and endothelial cell injury, with increased permeability of the alveolar-capillary membrane, leading to pulmonary edema, severe hypoxia, and difficulty w...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Lee LK,Medzikovic L,Eghbali M,Eltzschig HK,Yuan X

    更新日期:2020-11-01 00:00:00

  • The effectiveness of a perioperative smoking cessation program: a randomized clinical trial.

    abstract:BACKGROUND:Cigarette smoking by surgical patients is associated with increased complications, particularly perioperative respiratory problems and poor wound healing. In this study, we sought to determine whether a pragmatic perioperative smoking cessation intervention designed for a busy preadmission clinic would be su...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Lee SM,Landry J,Jones PM,Buhrmann O,Morley-Forster P

    更新日期:2013-09-01 00:00:00

  • The in vitro effects of isoflurane, sevoflurane, and propofol on platelet aggregation.

    abstract:UNLABELLED:We studied the in vitro effects of sevoflurane, isoflurane, and propofol anesthesia on platelet function. Thirty patients undergoing minor surgical procedures were divided into three groups (n = 10 each). Induction of anesthesia was achieved by using 5 mg/kg thiopental i.v., and 0.1 mg/kg vecuronium i.v. was...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Doğan IV,Ovali E,Eti Z,Yayci A,Göğüş FY

    更新日期:1999-02-01 00:00:00

  • Structure-affinity relationships and stereospecificity of several homologous series of local anesthetics for the beta2-adrenergic receptor.

    abstract:UNLABELLED:Local anesthetics inhibit binding of ligands to beta2-adrenergic receptors (beta2ARs), and, as a consequence, inhibit intracellular cAMP production. We hypothesized that among homologous local anesthetics, their avidity at inhibiting binding of tritiated dihydroalprenolol (3H-DHA) to beta2ARs would increase ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Butterworth J,James RL,Grimes J

    更新日期:1997-08-01 00:00:00

  • Propofol does not ameliorate cerebral venous oxyhemoglobin desaturation during hypothermic cardiopulmonary bypass.

    abstract:UNLABELLED:Reductions in cerebral venous oxyhemoglobin saturation (SjO2) occur during the rewarming phase of hypothermic cardiopulmonary bypass (CPB). We prospectively investigated the effects of propofol on these reductions in SjO2 (SjO2 <50%). Fiberoptic jugular bulb catheters were inserted in 30 patients undergoing ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Souter MJ,Andrews PJ,Alston RP

    更新日期:1998-05-01 00:00:00

  • Time course of muscle relaxation with a combination of pancuronium and tubocurarine.

    abstract::A combination of pancuronium and d-tubocurarine is associated with potentiation of the neuromuscular blocking effects of each drug used singly. The time to onset of maximum block and the time to 25% recovery after administration of equipotent (ED95) doses of pancuronium (0.07 mg/kg) alone, d-tubocurarine (0.51 mg/kg) ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Mirakhur RK,Pandit SK,Ferres CJ,Gibson FM

    更新日期:1984-04-01 00:00:00

  • Differential secretion of atrial and brain natriuretic peptide in critically ill patients.

    abstract::Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are cardiac hormones with natriuretic, vasorelaxant, and aldosterone-inhibiting properties. We analyzed the plasma of 178 critically ill patients for ANP, BNP, aldosterone, and serum sodium concentration, as well as serum and urine osmolality and sod...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Berendes E,Van Aken H,Raufhake C,Schmidt C,Assmann G,Walter M

    更新日期:2001-09-01 00:00:00

  • Atrial fibrillation after coronary artery bypass graft surgery is unrelated to cardiac abnormalities detected by transesophageal echocardiography.

    abstract:UNLABELLED:Atrial fibrillation is a common complication of coronary artery bypass graft (CABG) surgery that is associated with adverse patient outcomes. We evaluated whether preexisting abnormalities of cardiac structure or function detected with transesophageal echocardiography (TEE) are prevalent in patients later de...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Skubas NJ,Barzilai B,Hogue CW Jr

    更新日期:2001-07-01 00:00:00

  • Bispectral-index-guided versus clinically guided remifentanil/propofol analgesia/sedation for interventional radiological procedures: an observer-blinded randomized study.

    abstract::Patients undergoing potentially painful interventional radiological procedures generally require a combination of analgesia and sedation. This sedation/analgesia should allow the patient to communicate while also remaining calm. Bispectral index (BIS) monitoring could be useful in achieving this. The primary end-point...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Dahaba AA,Lischnig U,Kronthaler R,Bornemann H,Georgiev V,Rehak PH,Metzler H

    更新日期:2006-08-01 00:00:00

  • A clinical profile of a cohort of patients referred to an anesthesiology-based pediatric chronic pain medicine program.

    abstract:BACKGROUND:Pediatric chronic pain is very common and results in significant health care costs. Pediatric chronic pain is both an individual and a public health concern. The primary objective of this study was to generate a descriptive clinical profile of the patients referred to an anesthesiology-based pediatric chroni...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Vetter TR

    更新日期:2008-03-01 00:00:00

  • The Kepler intubation system.

    abstract::Our goal in this study was to develop a robotic intubation system and to conduct a feasibility pilot study on the use of a robotic intubation system for endotracheal intubations. The Kepler Intubation System was developed, consisting of a remote control center (joystick and intubation cockpit) linked to a standard vid...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Hemmerling TM,Wehbe M,Zaouter C,Taddei R,Morse J

    更新日期:2012-03-01 00:00:00

  • Perioperative Lung Protection: Clinical Implications.

    abstract::In the past, it was common practice to use a high tidal volume (VT) during intraoperative ventilation, because this reduced the need for high oxygen fractions to compensate for the ventilation-perfusion mismatches due to atelectasis in a time when it was uncommon to use positive end-expiratory pressure (PEEP) in the o...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Hol L,Nijbroek SGLH,Schultz MJ

    更新日期:2020-12-01 00:00:00

  • Pharmacokinetics of fentanyl in neonates.

    abstract::The pharmacokinetics of fentanyl were studied in fourteen neonates undergoing major surgical procedures. Five patients were less than 1 day of age, seven were 1-4 days old, and two were 7-14 days old. Fentanyl was given intravenously, 10 micrograms/kg (n = 1), 25 micrograms/kg (n = 4), or 50 micrograms/kg (n = 9), and...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Koehntop DE,Rodman JH,Brundage DM,Hegland MG,Buckley JJ

    更新日期:1986-03-01 00:00:00

  • Special article: mandragora: anesthetic of the ancients.

    abstract::Initial attempts at surgical anesthesia began many centuries ago, with the plants of antiquity. The mandragora, or mandrake, was used as a sedative and to induce pain relief for surgical procedures. It has been depicted in tablets and friezes since the 16th century before the common era (BCE) and used for its sedative...

    journal_title:Anesthesia and analgesia

    pub_type: 历史文章,杂志文章,评审


    authors: Chidiac EJ,Kaddoum RN,Fuleihan SF

    更新日期:2012-12-01 00:00:00

  • Fluid resuscitation with 6% hydroxyethyl starch (130/0.4) in acutely ill patients: an updated systematic review and meta-analysis.

    abstract:BACKGROUND:Recent research suggests that 6% hydroxyethyl starch (HES) 130/0.4 is one of the most frequently used resuscitation fluids worldwide. The retraction of studies evaluating its use necessitates a reevaluation of available evidence regarding its safety and efficacy. METHODS:We performed a systematic review and...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析,评审


    authors: Gattas DJ,Dan A,Myburgh J,Billot L,Lo S,Finfer S,CHEST Management Committee.

    更新日期:2012-01-01 00:00:00

  • Risk Factors for Intraoperative Hypoglycemia in Children: A Multicenter Retrospective Cohort Study.

    abstract:BACKGROUND:Intraoperative hypoglycemia can result in devastating neurologic injury if not promptly diagnosed and treated. Few studies have defined risk factors for intraoperative hypoglycemia. The authors sought to characterize children with intraoperative hypoglycemia and determine independent risk factors in a multic...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Riegger LQ,Leis AM,Golmirzaie KH,Malviya S

    更新日期:2020-06-25 00:00:00

  • Changes in cerebral blood flow velocity after release of intraoperative tourniquets in humans: a transcranial Doppler study.

    abstract::The effect of release of intraoperative thigh tourniquets on velocity of blood flow in the middle cerebral artery was examined in five patients given general anesthesia with controlled ventilation for lower extremity orthopedic procedures using transcranial Doppler sonography. Middle cerebral artery blood flow velocit...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Hirst RP,Slee TA,Lam AM

    更新日期:1990-11-01 00:00:00

  • Subcellular Energetics and Metabolism: Potential Therapeutic Applications.

    abstract::Part I of this review discussed the similarities between embryogenesis, mammalian adaptions to hypoxia (primarily driven by hypoxia-inducible factor-1 [HIF-1]), ischemia-reperfusion injury (and its relationship with reactive oxygen species), hibernation, diving animals, cancer, and sepsis, and it focused on the common...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Thiele RH

    更新日期:2017-06-01 00:00:00

  • Angiotensin-converting enzyme inhibitors increase vasoconstrictor requirements after cardiopulmonary bypass.

    abstract::Preoperative use of angiotensin-converting enzyme (ACE) inhibitors is common and has been associated with hypotension at separation from cardiopulmonary bypass (CPB). This study prospectively examined the influence of chronic preoperative ACE inhibitor use and other perioperative factors on the incidence of vasoconstr...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Tuman KJ,McCarthy RJ,O'Connor CJ,Holm WE,Ivankovich AD

    更新日期:1995-03-01 00:00:00

  • Effects of halothane on the cyclic 3',5'-adenosine monophosphate enzyme system in human platelets.

    abstract::A study of the effects of halothane on the cyclic 3',5'-adenosine monophosphate (cAMP) system in human platelets was undertaken since cAMP has been implicated in the regulation of the process of platelet aggregation and this anesthetic has been reported to decrease platelet aggregation and, in other tissues, to increa...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Walter F,Vulliemoz Y,Verosky Y,Triner L

    更新日期:1980-11-01 00:00:00

  • The effect of breath termination criterion on breathing patterns and the work of breathing during pressure support ventilation.

    abstract:UNLABELLED:With pressure support ventilation (PSV), each PSV breath is flow-cycled, and the breath termination criterion (TC) is usually nonadjustable. When TC does not match the interaction between the patient's inspiratory-expiratory efforts to the opening and closing of the inspiratory and expiratory valves, patient...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Tokioka H,Tanaka T,Ishizu T,Fukushima T,Iwaki T,Nakamura Y,Kosogabe Y

    更新日期:2001-01-01 00:00:00

  • Reassessment of the assumed A-V oxygen content difference in the shunt calculation.

    abstract::A study was undertaken in 15 patients to compare measured and assumed arteriovenous oxygen (A-V O2) content differences and their effects on resultant shunt calculations. All patients were on volume ventilators and demonstrated a stable cardiovascular state. Simultaneous measurements of the O2 content of a pulmonary a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Harrison RA,Davison R,Shapiro BA,Meyers SN

    更新日期:1975-03-01 00:00:00

  • Obturator versus femoral nerve block for analgesia after total knee arthroplasty.

    abstract:BACKGROUND:Both femoral and obturator nerve blocks have been suggested to be useful in relieving pain after total knee arthroplasty (TKA). We sought to compare their efficacy. METHODS:Sixty patients undergoing elective unilateral TKA under spinal anesthesia received in a randomized, double-blind manner a femoral, obtu...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Kardash K,Hickey D,Tessler MJ,Payne S,Zukor D,Velly AM

    更新日期:2007-09-01 00:00:00

  • Novel small molecule α9α10 nicotinic receptor antagonist prevents and reverses chemotherapy-evoked neuropathic pain in rats.

    abstract:BACKGROUND:Peripheral neuropathy is a common dose-limiting side effect of chemotherapy. There are no clinically proven analgesics for the treatment of this condition. Drugs from different classes have been tested with mixed results. Identification of novel molecular targets for analgesic(s) is important. Antagonism of ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Wala EP,Crooks PA,McIntosh JM,Holtman JR Jr

    更新日期:2012-09-01 00:00:00

  • Diagnostic Accuracy of Point-of-Care Gastric Ultrasound.

    abstract:BACKGROUND:Pulmonary aspiration of gastric contents is associated with significant perioperative morbidity and mortality. Previous studies have investigated the validity, reliability, and possible clinical impact of gastric ultrasound for the assessment of gastric content at the bedside. In the present study, we examin...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Kruisselbrink R,Gharapetian A,Chaparro LE,Ami N,Richler D,Chan VWS,Perlas A

    更新日期:2019-01-01 00:00:00

  • R(+)-, Rac-, and S(-)-bupivacaine stereostructure-specifically interact with membrane lipids at cardiotoxically relevant concentrations.

    abstract::It remains questionable whether local anesthetics can interact with membrane lipids at clinically relevant concentrations to show the difference between enantiomers. We compared the effects of bupivacaine stereoisomers on biomimetic membranes containing cardiolipin and cholesterol. Bupivacaine interacted with the memb...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Tsuchiya H,Mizogami M

    更新日期:2012-02-01 00:00:00

  • Postoperative analgesia at home after ambulatory hand surgery: a controlled comparison of tramadol, metamizol, and paracetamol.

    abstract::We compared in a prospective, randomized, double-blinded study the analgesic efficacy of three drugs in 120 ASA I and II patients scheduled to undergo ambulatory hand surgery with IV regional anesthesia. At discharge, oral analgesic tablets were prescribed as follows: tramadol 100 mg every 6 h, metamizol 1 g every 6 h...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rawal N,Allvin R,Amilon A,Ohlsson T,Hallén J

    更新日期:2001-02-01 00:00:00