Abstract:
Background:The novel oral antibiotic formulation Rifamycin SV-MMX®, with a targeted delivery to the distal small bowel and colon, was superior to placebo in treating travellers' diarrhea (TD) in a previous study. Thus, a study was designed to compare this poorly absorbed antibiotic with the systemic agent ciprofloxacin. Methods:In a randomized double-blind phase 3 study (ERASE), the efficacy and safety of Rifamycin SV-MMX® 400 mg twice daily (RIF-MMX) was compared with ciprofloxacin 500 mg twice daily in the oral treatment of TD. Overall, 835 international visitors to India, Guatemala or Ecuador with acute TD were randomized to receive a 3-day treatment with RIF-MMX (n = 420) or ciprofloxacin (n = 415). Primary endpoint was time to last unformed stool (TLUS), after which clinical cure was declared. Stools samples for microbiological evaluation were collected at the baseline visit and the end of treatment visit. Results:Median TLUS in the RIF-MMX group was 42.8 h versus 36.8 h in the ciprofloxacin group indicating non-inferiority of RIF-MMX to ciprofloxacin (P = 0.0035). Secondary efficacy endpoint results including clinical cure rate, treatment failure rate, requirement of rescue therapy as well as microbiological eradication rate confirmed those of the primary analysis indicating equal efficacy for both compounds. While patients receiving ciprofloxacin showed a significant increase of Extended Spectrum Beta Lactamase Producing-Escherichia coli (ESBL-E. Coli) colonization rates after 3-days treatment (6.9%), rates did not increase in patients receiving RIF-MMX (-0.3%). Both drugs were well-tolerated and safe. Conclusion:The novel multi-matrix formulation of the broad-spectrum, poorly absorbed antibiotic Rifamycin SV was found non-inferior to the systemic antibiotic ciprofloxacin in the oral treatment of non-dysenteric TD with the advantage of a lower risk of ESBL-E. Coli acquisition.
journal_name
J Travel Medjournal_title
Journal of travel medicineauthors
Steffen R,Jiang ZD,Gracias Garcia ML,Araujo P,Stiess M,Nacak T,Greinwald R,DuPont HLdoi
10.1093/jtm/tay116subject
Has Abstractpub_date
2018-01-01 00:00:00issue
1eissn
1195-1982issn
1708-8305pii
5193265journal_volume
25pub_type
杂志文章,随机对照试验abstract::We report a case of a 29-year-old woman who presented to hospital with fever, right upper quadrant pain, marked eosinophilia, and liver abscesses after returning to Canada from Bali, Indonesia. Diagnostic delay and prolonged antibiotic use led to morbidity before the eventual diagnosis and treatment of fascioliasis. ...
journal_title:Journal of travel medicine
pub_type: 杂志文章,评审
doi:10.1093/jtm/tay012
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Prior to initiation of a program of registration, training, standards, and audit for yellow fever vaccination centers (YFVCs) in England, the National Travel Health Network and Centre (NaTHNaC) assessed the current practice and resource needs of these centers. METHODS:A questionnaire was sent to all YFVCs o...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2008.00217.x
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:This experiment was carried out to determine whether there is any difference in circulating rabies antibody when rabies immune globulin is administered into fat or muscle tissue. METHODS:Blood samples were taken at 24 and 48 hours after administering 40 IU/kg body weight of purified equine rabies immune glo...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.2310/7060.2000.00057
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Influenza is the most common vaccine-preventable disease in travelers. It circulates year-round in the tropics, November to March in the northern hemisphere (NH), and April to October in the southern hemisphere (SH). In 2005, approximately 8.5 million US adults aged 18 years and older traveled to the Caribbe...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2008.00254.x
更新日期:2008-11-01 00:00:00
abstract:Background:Since the initial appearance in the 1980s, Enterobacteriaceae producing extended-spectrum β-lactamase (ESBL) have increased in prevalence and emerged as a major antimicrobial-resistant pathogen. The source of these antimicrobial-resistant bacteria in the developed world is an area of active investigation. M...
journal_title:Journal of travel medicine
pub_type: 杂志文章,评审
doi:10.1093/jtm/taw102
更新日期:2017-04-01 00:00:00
abstract::Japanese encephalitis (JE) is an infection caused by a mosquito-transmitted virus present in many parts of Asia, including India, and Oceania. Infection is usually asymptomatic, leading to overt encephalitis in only 0.1-5% of infected individuals. When encephalitis occurs it is usually severe, with a 25% fatality rate...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.1997.tb00766.x
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:The risk of malaria to visitors to South Africa's nature reserves is unknown. Current recommendations for travelers are based on malaria incidence rates in local communities. These rates may well overestimate travelers' malaria risk and lead to unnecessary use of antimalarial prophylaxis with associated drug...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.1998.tb00502.x
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:International travel can expose travellers to pathogens not commonly found in their countries of residence, like dengue virus. Travellers and the clinicians who advise and treat them have unique needs for understanding the geographic extent of risk for dengue. Specifically, they should assess the need for pr...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1093/jtm/taw062
更新日期:2016-09-13 00:00:00
abstract::A case of Japanese encephalitis virus (JEV) infection is reported in a young traveler returning from Thailand. Clinical suspicion of JEV in travelers returning from endemic areas with neurologic symptoms is warranted. Confirmation of the diagnosis is complex and requires specialized laboratory services. Individualized...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2011.00582.x
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Following the severe acute respiratory syndrome (SARS) outbreak, remote-sensing infrared thermography (IRT) has been advocated as a possible means of screening for fever in travelers at airports and border crossings, but its applicability has not been established. We therefore set out to evaluate (1) the fea...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.2310/7060.2004.19102
更新日期:2004-09-01 00:00:00
abstract::The diagnostic attitude of western physicians toward migrants' complaints is often an unstable balance between the obstinate search for exotic tropical diseases and the overappreciation of the cultural dimensions of symptoms. Such attitude may divert attention from organic diseases. The careful assessment of all level...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2009.00312.x
更新日期:2009-07-01 00:00:00
abstract::Background: The risk of acquiring HIV-1 and HIV-2 infections among expatriates in, and travelers to, West Africa is not known. The objective of the study was to examine the risk of human immunodeficiency virus type 1 and type 2 (HIV-1 and HIV-2) infections among Peace Corps volunteers in West Africa. Methods: A cross-...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.1995.tb00647.x
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:International travel and trade are known to be associated with the risk of spreading communicable diseases across borders. No international surveillance system for infectious diseases on ships exists. Outbreak reports and systematic studies mainly focus on disease activity on cruise ships. The study aims to ...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2009.00343.x
更新日期:2009-11-01 00:00:00
abstract::Hepatitis E virus (HEV) is the main etiological agent for the enterically transmitted form of non-A, non-B hepatitis (ET-NANB), and is associated with epidemic and sporadic forms of the disease,1 mainly in some developing countries.2 In Argentina, no ET-NANB hepatitis epidemics have been described, and no epidemiologi...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.1997.tb00788.x
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:In 1993 more than 1 million Swiss residents traveled to a tropical or subtropical country. Although most pretravel advice is given by general practitioners, a number of travelers also seek advice from pharmacists. Little is known about the quantity and quality of travel advice given or the sources of informa...
journal_title:Journal of travel medicine
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1708-8305.1999.tb00838.x
更新日期:1999-06-01 00:00:00
abstract::We report two cases of symptomatic neurocysticercosis in two migrants whose negative serology delayed appropriate treatment for 9 and 6 months, respectively. Seroconversion occurred after treatment, which was associated with paradoxical reaction in one patient. Long-term outcome was good in both patients. ...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2012.00658.x
更新日期:2012-12-01 00:00:00
abstract::Nine imported Zika virus (ZIKV) infections (four through temperature monitoring and epidemiological investigation at entry and five by active surveillance tracking of index case contacts during follow-up; from Venezuela [n = 5], Samoa [n = 3] and both Samoa and Fiji [n = 1]) were detected in mainland China from Februa...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1093/jtm/taw047
更新日期:2016-07-04 00:00:00
abstract:BACKGROUND:Artemisinin-based combination therapy (ACT) is the global standard of care for uncomplicated falciparum malaria. First reports of ACT resistance came from western Cambodia and the Thailand-Cambodia border in 2002-2004. The subsequent emergence and expansion of Plasmodium falciparum strains resistant to the a...
journal_title:Journal of travel medicine
pub_type: 杂志文章,评审
doi:10.1093/jtm/taz030
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Conventional treatment of imported malaria in Italy consists of quinine or mefloquine. Since beta-arthemeter is now available, an open-label pharmacodynamic analysis was performed in 73 adults with uncomplicated Plasmodium falciparum malaria. In vitro susceptibility to mefloquine and quinine was evaluated at...
journal_title:Journal of travel medicine
pub_type: 临床试验,杂志文章
doi:10.2310/7060.2005.12305
更新日期:2005-05-01 00:00:00
abstract::In recent years, several studies have shown that Cyclospora cayetanensis is a worldwide intestinal pathogen, and it has been implicated in a number of sporadic cases and epidemic outbreaks of diarrheal illness in several endemic areas. The parasite is associated with prolonged and relapsing watery diarrhea in immunoco...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.2310/7060.2004.13640
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:The effectiveness of preventive measures in combating travel-related illnesses is well recognized. However, there is a lack of information on the economic value of any travel-associated preventive measures in the literature. OBJECTIVES:The purpose of this article is to report the values of willingness to pa...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.2310/7060.2005.12202
更新日期:2005-03-01 00:00:00
abstract::Infections caused by Burkholderia pseudomallei are rare in nonendemic areas, such as Scandinavia. We report the first two cases of melioidosis in Norway presenting with bacteraemia and splenic and prostatic abscesses, respectively. ...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2011.00550.x
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Schistosomiasis is common in many African regions and poses a risk for travelers and the local population. So far, schistosomiasis in travelers or expatriates returning from the Tanzanian bank of Lake Tanganyika has not been reported. METHODS:We report a group of students who sought treatment with signs of ...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/jtm.12069
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Jellyfish are a common cause of injury throughout the world, with fatalities and severe systemic events not uncommon after tropical stings. The internet is a recent innovation to gain information on real-time health issues of travel destinations, including Southeast Asia. METHODS:We applied the model of int...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2011.00531.x
更新日期:2011-07-01 00:00:00
abstract::We describe a case of trichinellosis diagnosed at the Division of Infectious Diseases, Hospital of Lugano, in January 2009. This case was associated with a cluster of cases and was traced to the consumption of contaminated meat after a wild boar hunt in Bosnia. ...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2012.00603.x
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Infectious diarrhea is a common problem among travelers. Expert guidelines recommend the prompt use of antibiotics for self-treatment of moderate or severe travelers' diarrhea (TD). There is limited data on whether travelers follow these self-treatment guidelines. We evaluated the risk factors associated wit...
journal_title:Journal of travel medicine
pub_type: 杂志文章,多中心研究
doi:10.1111/jtm.12179
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Drug abuse constitutes a worldwide problem. The purpose of this study was to investigate the characteristics of illicit drug use during long-term travel to the tropics, and to estimate the effects of antidrug brochures provided before travel on the use of drugs during travel. METHODS:An interventional study...
journal_title:Journal of travel medicine
pub_type: 临床试验,杂志文章
doi:10.2310/7060.2004.17047
更新日期:2004-03-01 00:00:00
abstract::Primary herpes infections usually require intimate contact of mucous membranes by either oral or sexual means.1,2 Infrequently, other types of contact have been described.3-5 Such was the case with an outbreak of herpes gladiatorum at a high-school wrestling camp, or a dental student who became infected from a patient...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.1997.tb00802.x
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:International travel and use of modern information technology are expressions of modern life style. Seeking on-line travel health advice via E-mail for preventive (teleprevention) or diagnostic reasons may become increasingly popular among patients with financial resources and Internet access. This study was...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.2310/7060.2001.24423
更新日期:2001-05-01 00:00:00
abstract::Whether the result of cyclical atmospheric changes, anthropogenic activities, or combinations of both, authorities now agree that the earth is warming from a variety of climatic effects, including the cascading effects of greenhouse gas emissions to support human activities. To date, most reports of the public health ...
journal_title:Journal of travel medicine
pub_type: 杂志文章,评审
doi:10.1111/j.1708-8305.2006.00072.x
更新日期:2006-11-01 00:00:00