Abstract:
BACKGROUND:Conventional treatment of imported malaria in Italy consists of quinine or mefloquine. Since beta-arthemeter is now available, an open-label pharmacodynamic analysis was performed in 73 adults with uncomplicated Plasmodium falciparum malaria. In vitro susceptibility to mefloquine and quinine was evaluated at admission. METHODS:According to clinical status, baseline parasitemia (P(0)), and premunition, the patients received intravenous quinine, oral mefloquine, or beta-arthemeter. The following parameters were measured: parasitemia at 0, 6, 12, and 24 hours and then every 24 hours until negative; time to 50%, 90%, and 100% reduction in parasite density (PC(50), PC(90), and PCT); parasite reduction ratio at 24 and 48 hours (PRR(24) and PRR(48)); percentage of patients with undetectable parasitemia at 48 hours (PPUP(48)); time required to eradication; in vitro susceptibility to mefloquine and quinine by World Health Organization Microtest Mark III. RESULTS:Of the study patients, 54.8% were immigrants from malaria-endemic countries. All the infections were acquired in Africa. All the patients were treated successfully. According to the pharmacodynamic parameters measured, no significant differences were recorded among patients with or without prior exposure to malaria. Pharmacodynamic comparison was performed between quinine and beta-arthemeter. Significantly higher clearance times were recorded for beta-arthemeter vs quinine (PC(50), PC(90), and PCT: 16.8, 42.6, and 72 h for quinine vs 7.9, 12.2, and 48 h for beta-arthemeter; p values: .02, < .0001, and .008, respectively). The number of patients who obtained a PPUP(48) with beta-arthemeter was higher than with quinine (66.7 vs 9.1%, p < .003), and PRR(24) was significantly higher in beta-arthemeter-treated patients (617 vs 3.15, p = .0001). PRR(48) and time to eradication were not measurable in the beta-arthemeter group (negative P at 48 h in most cases). Two recrudescences occurred after 5 and 7 days of beta-arthemeter monotherapy. All strains were fully susceptible to quinine and mefloquine. CONCLUSIONS:Pharmacodynamic properties of mefloquine and quinine are in the range reported in literature. The better PCT and pharmacodynamics of beta-arthemeter suggest that it could be used as a first-line agent, coadministered with mefloquine.
journal_name
J Travel Medjournal_title
Journal of travel medicineauthors
Caramello P,Canta F,Cavecchia I,Sergi G,Lipani F,Calleri G,Gobbi F,Di Perri Gdoi
10.2310/7060.2005.12305subject
Has Abstractpub_date
2005-05-01 00:00:00pages
127-32issue
3eissn
1195-1982issn
1708-8305journal_volume
12pub_type
临床试验,杂志文章abstract::Malaria infections have become an increasing public health problem in Europe, especially those imported into nonendemic areas. The transmission and diffusion of malaria has increased, especially over the last decade, due to changes in agricultural practices, vector resistance to insecticides, and most relevantly, incr...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.1994.tb00583.x
更新日期:1994-09-01 00:00:00
abstract::Zika and Ebola viruses can persist in semen and pose a risk for sexual transmission. To determine if dengue virus, another flavivirus, is similarly detectable in semen, we performed dengue PCR on semen in five patients with acute dengue virus infection. All five tested negative, suggesting that dengue does not pose a ...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1093/jtm/tay023
更新日期:2018-01-01 00:00:00
abstract::Background: The risk of acquiring HIV-1 and HIV-2 infections among expatriates in, and travelers to, West Africa is not known. The objective of the study was to examine the risk of human immunodeficiency virus type 1 and type 2 (HIV-1 and HIV-2) infections among Peace Corps volunteers in West Africa. Methods: A cross-...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.1995.tb00647.x
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:International travel can expose travellers to pathogens not commonly found in their countries of residence, like dengue virus. Travellers and the clinicians who advise and treat them have unique needs for understanding the geographic extent of risk for dengue. Specifically, they should assess the need for pr...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1093/jtm/taw062
更新日期:2016-09-13 00:00:00
abstract::Nine imported Zika virus (ZIKV) infections (four through temperature monitoring and epidemiological investigation at entry and five by active surveillance tracking of index case contacts during follow-up; from Venezuela [n = 5], Samoa [n = 3] and both Samoa and Fiji [n = 1]) were detected in mainland China from Februa...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1093/jtm/taw047
更新日期:2016-07-04 00:00:00
abstract::Alternative approaches to malaria chemoprophylaxis are discussed in light of the difficulties of executing clinical trials within limits of infection rates and ethics. ...
journal_title:Journal of travel medicine
pub_type: 社论
doi:10.1093/jtm/taw065
更新日期:2016-09-30 00:00:00
abstract:BACKGROUND:More than 1.5 billion passengers travel by aircraft every year. Leg edema, as a sign of venous stasis, is a well-known problem among passengers during and after long-haul flights. Until now, no studies have been done on the development of leg edema and fluid shifts under real flight conditions. The aim of ou...
journal_title:Journal of travel medicine
pub_type: 临床试验,杂志文章
doi:10.2310/7060.2003.9359
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Dermatitis linearis is a skin condition that affects both local populations and travelers alike. Dermatitis linearis is caused by some beetles within the subtribe Paederina and manifests as painful lesions, blisters and intense itching. Though outbreaks are widespread, the condition as a whole still remains ...
journal_title:Journal of travel medicine
pub_type: 杂志文章,评审
doi:10.1093/jtm/taw032
更新日期:2016-05-13 00:00:00
abstract::Primary herpes infections usually require intimate contact of mucous membranes by either oral or sexual means.1,2 Infrequently, other types of contact have been described.3-5 Such was the case with an outbreak of herpes gladiatorum at a high-school wrestling camp, or a dental student who became infected from a patient...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.1997.tb00802.x
更新日期:1997-09-01 00:00:00
abstract::Retrospective studies have shown that the first HIV positive patient in the Federal Republic (FR) of Yugoslavia (Serbia and Montenegro) was detected among intravenous drug users (IDUs) in 1981. The first two cases of AIDS in Yugoslavia were registered in 19851; one of them was infected in subSaharan Africa. The object...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.1996.tb00736.x
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Hajj, the pilgrimage to Mecca, is one of the obligatory religious duties of Islam. The travel clinic of the Public Health Service (PHS) Amsterdam administers vaccinations, including the required meningitis ACYW135 vaccine, and provides travelers with individual recommendations for all their travels. METHODS...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2011.00515.x
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Between 1995 and 1997, stool samples of 322 Austrian tourists returning from abroad with diarrhea were examined for bacteria, parasites and viruses. METHODS:Epidemiologic data were collected from information furnished by physicians and hospitals and from questionnaires. Moreover, testing expenses and additi...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.1998.tb00466.x
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND:In February 2012, crew and passengers of a cruise ship sailing off the coast of São Paulo, Brazil, were hospitalized for acute respiratory illness (ARI). A field investigation was performed to identify the disease involved and factors associated. METHODS:Information on passengers and crew with ARI was obtai...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/jtm.12132
更新日期:2014-09-01 00:00:00
abstract::Incidence of malaria is increasing in travelers and soldiers. In 2006, a survey was performed in a French battalion returning from a malaria-endemic area. According to the chemoprophylaxis plasma concentration and the individuals' reports, the noncompliance rates were high, respectively, 63.4 and 54.7%. ...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2008.00219.x
更新日期:2008-09-01 00:00:00
abstract:AIM:International travel has become popular among young adults. This study evaluated the rate and characteristics of travel-associated health risks among young adults with type 1 diabetes mellitus (T1DM) compared with healthy same-aged individuals. METHODS:A retrospective study was conducted of 47 young adults with T1...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/jtm.12136
更新日期:2014-11-01 00:00:00
abstract:Background:Since the initial appearance in the 1980s, Enterobacteriaceae producing extended-spectrum β-lactamase (ESBL) have increased in prevalence and emerged as a major antimicrobial-resistant pathogen. The source of these antimicrobial-resistant bacteria in the developed world is an area of active investigation. M...
journal_title:Journal of travel medicine
pub_type: 杂志文章,评审
doi:10.1093/jtm/taw102
更新日期:2017-04-01 00:00:00
abstract::As tropical countries become common travelers' destinations, more and more returning travelers are expected to present with cutaneous lesions secondary to myiasis. The skin lesion starts as a small red papule and gradually enlarges to become a furuncle. Familiarity with the characteristic clinical presentation and pro...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.2310/7060.2005.12411
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Drug abuse constitutes a worldwide problem. The purpose of this study was to investigate the characteristics of illicit drug use during long-term travel to the tropics, and to estimate the effects of antidrug brochures provided before travel on the use of drugs during travel. METHODS:An interventional study...
journal_title:Journal of travel medicine
pub_type: 临床试验,杂志文章
doi:10.2310/7060.2004.17047
更新日期:2004-03-01 00:00:00
abstract:Background:Dengue fever (DF) is a frequently imported arthropod-borne infection in the United Kingdom but its broad range of clinical presentations makes it potentially unrecognized by clinicians. Methods:We conducted a 6-year retrospective case note review of laboratory confirmed DF patients in East London in the per...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1093/jtm/tax015
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Nonimmune travelers in malaria-endemic areas are exposed to transmission and may experience clinical malaria attacks during or after their travel despite using antivectorial devices or chemoprophylaxis. Environment plays an essential role in the epidemiology of this disease. Remote-sensed environmental infor...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2008.00202.x
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Little is known about the awareness of travellers with diabetes about the health effects of international travel. This study aimed to design and validate a questionnaire to examine the travel health knowledge, attitudes and practices of people living with type 1 diabetes. METHODS:A set of 74 items based on ...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1093/jtm/taaa110
更新日期:2020-09-26 00:00:00
abstract::Travellers visiting friends and relatives (VFRs) often have complex pre-travel needs. We identified the characteristics, destinations, vaccinations and pre-travel advice provided to VFRs and compared these with non-VFR travellers. The significant differences we found suggest that future research should focus on improv...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1093/jtm/tax038
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Few data are available on the incidence and predictors of serious altitude illness in travelers who visit pre-travel clinics. Travel health consultants advise on measures to be taken in case of serious altitude illness but it is not clear if travelers adhere to these recommendations. METHODS:Visitors to six...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/jtm.12160
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Sexual behavior during travel has increasingly become a focus of travel medicine research. The perceived freedom when away from home can lead to increased casual sexual activities, often unprotected. Local sexual partners, particularly those who are in close contact with tourists due to their occupation, nee...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2007.00110.x
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Over the last 150 years, a little South American fish with alleged unsavory habits has become the stuff legends are made of. With growing visitor numbers to the Amazon basin, the question of whether the animal poses a threat to the many travelers to the region arises. METHODS:Scientific literature was ident...
journal_title:Journal of travel medicine
pub_type: 历史文章,杂志文章,评审
doi:10.1111/jtm.12005
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Before the impact of the coronavirus disease 2019 pandemic, cruise travel had experienced exponential growth in the preceding decade. Travel medicine practitioners were increasingly called upon to provide pre-cruise travel advice and medical clearance. Demand for these services will return at some time in th...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1093/jtm/taaa111
更新日期:2020-09-26 00:00:00
abstract::Loiasis, caused by the filarial nematode Loa loa, is often asymptomatic but frequently manifests as episodic angioedema and periocular migration of adult worms. Hence also known as the eye worm.(1) It is rarely encountered in the United States among travelers and immigrants. This report describes a case of loiasis in ...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2007.00166.x
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Previous studies investigating the travelers' knowledge, attitudes, and practices (KAP) profile indicated an important educational need among those traveling to risk destinations. Initiatives to improve such education should target all groups of travelers, including business travelers, those visiting friends...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2011.00578.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:Scarce data are available on the occurrence of ailments and diseases in children during travel. We studied the characteristics and frequencies of ailments in children aged 0 to 18 years and their parents during traveling. METHODS:A prospective observational study on ailments reported by children and parents ...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.1111/j.1708-8305.2011.00551.x
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Following the severe acute respiratory syndrome (SARS) outbreak, remote-sensing infrared thermography (IRT) has been advocated as a possible means of screening for fever in travelers at airports and border crossings, but its applicability has not been established. We therefore set out to evaluate (1) the fea...
journal_title:Journal of travel medicine
pub_type: 杂志文章
doi:10.2310/7060.2004.19102
更新日期:2004-09-01 00:00:00