Fluctuating PEEP (F-PEEP) versus conventional PEEP in dogs with asymmetrical lung injury.

Abstract:

:Fluctuating PEEP (F-PEEP) is a newly developed PEEP in which end-expiratory pressure (EEP) is periodically changed within a certain range. In a dog model with unilateral lung injury induced by the introduction of hydrochloric acid, F-PEEP in which the EEP was periodically changed from 0.5 to 1.5 kPa at periods of 6 min, and conventional PEEP (C-PEEP) with an optimized EEP of 1.0 kPa, were each applied for 30 min. F-PEEP produced a significantly greater improvement of PaO2 and intrapulmonary shunt (QS/QT) than C-PEEP, and at the low EEP phase, the greatest improvement accompanied by an increased dynamic compliance and a large cardiac output was obtained. These results suggest that F-PEEP provides a useful mode of artificial ventilation for the treatment of unilateral lung injury.

authors

Inaba H,Sato J,Uchida H,Sakurada M,Ohwada T,Mizuguchi T

doi

10.1111/j.1399-6576.1988.tb02748.x

subject

Has Abstract

pub_date

1988-07-01 00:00:00

pages

374-8

issue

5

eissn

0001-5172

issn

1399-6576

journal_volume

32

pub_type

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