Sublingual premedication with brotizolam.

Abstract:

:This randomized, double-blind and double-dummy study was carried out in order to compare the perioperative sedation after premedication with either brotizolam 0.25-0.50 mg sublingually or diazepam 5-10 mg orally. Sixty-two patients aged 18-60 years scheduled for minor gynaecological surgery in general anaesthesia were included. Assessments were: 1. auditory continued response time (ACRT); 2. coma scale; 3. anxiety scale; and 4. final patient questionnaire. One hour after premedication the brotizolam group was more sedated, based on ACRT (P < 0.01) and the coma scale (P < 0.05). The final questionnaire showed (P < 0.05) that the brotizolam group was more satisfied with the effect of the premedication. Seven hours after the premedication the ACRT scores in both groups were similar to those before premedication and all the patients could walk about freely. In conclusion, as a premedicant in outpatients sublingual brotizolam appears to be a good alternative to diazepam.

authors

Laub M,Espersen K,Ejlersen E,Krintel JJ

doi

10.1111/j.1399-6576.1992.tb03560.x

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

764-6

issue

8

eissn

0001-5172

issn

1399-6576

journal_volume

36

pub_type

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