Vitamin D deficiency and course of frailty in a depressed older population.

Abstract:

:Objective: To study the association between vitamin D levels and frailty, its components and course in a depressed sample.Methods: Baseline and two-year follow-up data from the depressed sample of the Netherlands Study of Depression in Older persons (NESDO), a prospective observational cohort study, were analyzed. The 378 participants (aged 60-93) had a diagnosis of depression according to DSM-IV criteria. Frailty was defined according to Fried's physical phenotype. 25-OH vitamin D measurement was performed by liquid chromatography - tandem mass spectrometry. Linear and logistic regression analyses were performed, adjusted for covariates.Results: Higher vitamin D levels were cross-sectionally associated with lower prevalence of frailty (OR 0.64 [95%-CI 0.45 - 0.90], p = .010), predicted a lower incidence of frailty among non-frail depressed patients (OR 0.51 [95%-CI 0.26 - 1.00], p=.050), and, surprisingly, the persistence of frailty among frail depressed patients (OR 2.82 [95%-CI 1.23 - 6.49], p=.015).Conclusions: In a depressed population, higher vitamin D levels were associated with lower prevalence and incidence of frailty. Future studies should examine whether the favorable effect of low vitamin D levels on the course of frailty can be explained by confounding or whether unknown pathophysiological mechanisms may exert protective effects.

journal_name

Aging Ment Health

journal_title

Aging & mental health

authors

van den Berg KS,Arts MHL,Collard RM,van den Brink RHS,Comijs HC,Marijnissen RM,Oude Voshaar RC

doi

10.1080/13607863.2018.1515885

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

49-55

issue

1

eissn

1360-7863

issn

1364-6915

journal_volume

24

pub_type

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