Prefrontal-limbic connectivity during worry in older adults with generalized anxiety disorder.

Abstract:

OBJECTIVES:Although generalized anxiety disorder (GAD) is one of the most prevalent anxiety disorders in older adults, very little is known about the neurobiology of worry, the hallmark symptom of GAD in adults over the age of 60. This study investigated the neurobiology and neural circuitry of worry in older GAD patients and controls. METHOD:Twenty older GAD patients and 16 age-matched controls (mean age = 67.88) were compared on clinical measures and neural activity during worry using functional magnetic resonance imaging. RESULTS:As expected, worry elicited activation in frontal regions, amygdala, and insula within the GAD group, with a similar but less prominent frontal pattern was observed in controls. Effective connectivity analyses revealed a positive directional circuit in the GAD group extending from ventromedial through dorsolateral prefrontal cortices, converging on the amygdala. A less complex circuit was observed in controls with only dorsolateral prefrontal regions converging on the amygdala; however, a separate circuit passing through the orbitofrontal cortex converged on the insula. CONCLUSION:Results elucidate a different neurobiology of pathological versus normal worry in later life. A limited resource model is implicated wherein worry in GAD competes for the same neural resources (e.g. prefrontal cortical areas) that are involved in the adaptive regulation of emotion through cognitive and behavioral strategies.

journal_name

Aging Ment Health

journal_title

Aging & mental health

authors

Mohlman J,Eldreth DA,Price RB,Staples AM,Hanson C

doi

10.1080/13607863.2015.1109058

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

426-438

issue

4

eissn

1360-7863

issn

1364-6915

journal_volume

21

pub_type

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