Cellular and molecular bases for dystocia.

Abstract:

:In this review I have briefly outlined some of the cellular and molecular reasons for dystocia. I have described the myogenic, that may control the normal progression of labor and explain inadequate uterine contractility associated with dystocia. I have placed particular emphasis on our studies of gap junctions and their regulation. These studies show that there are specific physiologic mechanisms for regulating structural and functional coupling between myometrial cells during labor. The integration of these control mechanisms probably operates to ensure appropriate activation and maintenance of synchronous contractility of the myometrium and effective delivery.

journal_name

Clin Obstet Gynecol

authors

Garfield RE

doi

10.1097/00003081-198703000-00004

subject

Has Abstract

pub_date

1987-03-01 00:00:00

pages

3-18

issue

1

eissn

0009-9201

issn

1532-5520

journal_volume

30

pub_type

杂志文章,评审
  • Clinical relevance of fetal gonadal structure and function.

    abstract::The foregoing discussion is consistent with the following conclusions: First structural differentiation of the gonads, consonant with chromosomal sex of human fetuses, requires complex interactions of primordial germ cells with coelomic and mesonephric epithelial cells and mesenchymal cells in the genital ridge. The m...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: diZerega GS,Ross GT

    更新日期:1980-09-01 00:00:00

  • Controversies in the Management of Endometrioma: To Cure Sometimes, to Treat Often, to Comfort Always?

    abstract::Endometriomas are common in reproductive-aged women, but controversy exists regarding their management. PubMed was searched to identify pertinent studies on outcomes of medical and surgical management of endometrioma, with focus on randomized controlled trials and meta-analyses. Surgical excision is more effective tha...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0000000000000151

    authors: Johnstone EB,Link MH

    更新日期:2015-12-01 00:00:00

  • Characterization of a TP53 Somatic Variant of Unknown Function From an Ovarian Cancer Patient Using Organoid Culture and Computational Modeling.

    abstract::In our proof-of-concept study of 1 patient with stage IIIC carcinosarcoma of the ovary, we discovered a rare mutation in the tumor suppressor, TP53, that results in the deletion of N131. Immunofluorescence imaging of the organoid culture revealed hyperstaining of p53 protein. Computational modeling suggests this resid...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/GRF.0000000000000516

    authors: Bi J,Thiel KW,Litman JM,Zhang Y,Devor EJ,Newtson AM,Schnieders MJ,Gonzalez Bosquet J,Leslie KK

    更新日期:2020-03-01 00:00:00

  • Pruritus in pregnancy.

    abstract::Diagnosis of the cause of pruritus in a pregnant patient should be approached systematically, beginning with a detailed history (especially drug exposure) and physical examination. Systemic diseases must be excluded. Liver function tests and hepatitis screen are in order if symptoms suggest liver dysfunction. Stool ex...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00003081-199012000-00007

    authors: Dacus JV

    更新日期:1990-12-01 00:00:00

  • Subclinical thyroid dysfunction during pregnancy.

    abstract::There is compelling data and a rationale for embarking on screening to identify pregnant women with some of the multiple classes of subclinical thyroid dysfunction. However, the evidence to support such screening and treatment is lacking. Several important trials are underway or undergoing peer review that may provide...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e31822e27e3

    authors: Casey BM

    更新日期:2011-09-01 00:00:00

  • Cervical assessment.

    abstract::The relationship between the clinical state of the cervix and spontaneous onset of labor has long been known. The cervix can be characterized by evaluating five parameters: effacement, dilatation, firmness, position, and level of the presenting part. The relative associations between successful labor induction and the...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00003081-199506000-00005

    authors: Fuentes A,Williams M

    更新日期:1995-06-01 00:00:00

  • Surgical approaches to postobstetrical perineal body defects (rectovaginal fistula and chronic third and fourth-degree lacerations).

    abstract::Rectovaginal fistulas and chronic anal sphincter lacerations are uncommon complications that are most often secondary to vaginal delivery, gynecologic surgery, and inflammatory bowel disease. In this chapter, we will review the pertinent anatomy, focusing on the 6 structures that should be considered during the repair...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e3181cf7488

    authors: Delancey JO,Berger MB

    更新日期:2010-03-01 00:00:00

  • Amniotic and thromboembolism.

    abstract::Embolic phenomena in pregnancy demand rapid investigation and treatment. Regardless, some patients will not survive due to the enormity of the insult. Optimally, such patients should be treated in tertiary care centers, but this is not always possible. ...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00003081-199009000-00013

    authors: Chatelain SM,Quirk JG Jr

    更新日期:1990-09-01 00:00:00

  • Robotic-assisted surgery for the community gynecologist: can it be adopted?

    abstract::The American College of Obstetricians and Gynecologists and the American Association of Gynecologic Laparoscopists confirm advantages of conventional minimally invasive surgery over laparotomy for benign gynecological procedures; however, adoption remains low for the general gynecologist. A systematic search for gynec...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e31822b4998

    authors: Payne TN,Pitter MC

    更新日期:2011-09-01 00:00:00

  • Human papillomavirus and cervical disease in adolescents.

    abstract::The addition of the human papillomavirus vaccination and the 2006 national guidelines for the management of abnormal cervical cytology have led to significant changes in the management of cervical disease among adolescents. This article reviews recommendations for prevention, screening, diagnosis, and management of ce...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e318172d0dc

    authors: Guido R

    更新日期:2008-06-01 00:00:00

  • The management of detrusor instability.

    abstract::Detrusor instability is a urodynamic diagnosis made when the detrusor is shown objectively to contract, spontaneously or on provocation, during the filling phase of a cystometrogram while the patient is attempting to inhibit micturition. It often is responsible for symptoms of urgency, frequency, nocturia, urge incont...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00003081-199006000-00021

    authors: Wall LL

    更新日期:1990-06-01 00:00:00

  • Norgestimate.

    abstract::Norgestimate (NGM) is one of a class of newer, more selective progestins. The authors describe its structure and biologic activity, contraceptive effectiveness, cycle control, metabolic effects, carbohydrate metabolism, coagulation factors, and clinical side effects. NGM-containing oral contraceptives (OC), either a...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00003081-199538040-00019

    authors: Corson SL

    更新日期:1995-12-01 00:00:00

  • The eye in pregnancy: ophthalmologic and neuro-ophthalmologic changes.

    abstract::A variety of changes in the eye can occur during pregnancy. These can be physiological, pathologic related to the pregnancy, or pathologic unrelated to the pregnancy. Pregnancy also can affect preexisting conditions. Pregnant women often discuss changes in their health first with their obstetrician; therefore, knowled...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e31828f273c

    authors: Grant AD,Chung SM

    更新日期:2013-06-01 00:00:00

  • Errors and analysis of errors.

    abstract::Methods of analyzing errors and proactively preventing errors are discussed. A framework for using these concepts is presented. ...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e3181899a5a

    authors: Mulligan MA,Nechodom P

    更新日期:2008-12-01 00:00:00

  • Management of the patient in labor who has abused substances.

    abstract::The drug abusing patient can provide a management dilemma for health care providers including nurses, obstetrician, anesthesiologist, and pediatrician. Certain illicit drugs may mimic other diseases of pregnancy and result in inappropriate treatment for the mother and child. Pain management may be challenging in such ...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e318282738b

    authors: Geary FH Jr,Turnquest Wells MA

    更新日期:2013-03-01 00:00:00

  • Assessment and optimization of uterine activity during labor.

    abstract::Accurate assessment of uterine activity during labor is essential to promote optimal patient outcomes. This review provides clinicians with information to develop an evidence-based, standardized approach to the evaluation and management of uterine activity during labor including identification and treatment of excessi...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e31820a06aa

    authors: Simpson KR,Miller L

    更新日期:2011-03-01 00:00:00

  • Sonographic diagnosis of fetal growth disorders.

    abstract::In summary, accurate identification of fetal growth disorders remains a difficult clinical challenge. Many diagnostic parameters have been devised to diagnose these conditions, however, no single test alone allows a confident antenatal diagnosis of IUGR or macrosomia to be established. Until new criteria or new method...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00003081-198803000-00007

    authors: Mintz MC,Landon MB

    更新日期:1988-03-01 00:00:00

  • The role of sonography in pediatric gynecology.

    abstract::Sonography has a major role in the evaluation of children with gynecologic disorders. The size, consistency, and origin of pelvic masses and the status of the internal genitalia can be evaluated. Sonography is useful in evaluation of children with precocious puberty because it can demonstrate adult-size ovaries in tru...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00003081-198709000-00027

    authors: Fleischer AC,Shawker TH

    更新日期:1987-09-01 00:00:00

  • Removal of adnexa at the time of vaginal hysterectomy.

    abstract::Removal of the fallopian tubes and ovaries at the time of vaginal hysterectomy is a skill that must be acquired if one is to be a competent vaginal surgeon. Various techniques have been described and will be reviewed in this chapter. A single technique or series of steps often must be modified depending on the descent...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e3181ce87fc

    authors: Shepherd JP,Zyczynski HM

    更新日期:2010-03-01 00:00:00

  • Screening for osteoporosis.

    abstract::Determining which women should undergo dual-energy x-ray absorptiometry testing should be based on rational screening criteria. Screening tests should be simple to perform, readily available, and very sensitive. Clinical risk factors have been proposed by numerous professional societies as a way to screen women for fu...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e3182a99814

    authors: Helmrich G

    更新日期:2013-12-01 00:00:00

  • Long-term outcomes in mothers diagnosed with gestational diabetes mellitus and their offspring.

    abstract::Mothers with gestational diabetes mellitus (GDM) are at high lifetime risk of developing type 2 diabetes mellitus. The magnitude of risk for cardiovascular disease after GDM is less well established. Recently, intervention trials using lifestyle modification or medications used to treat type 2 DM have successfully pre...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e31815a61d6

    authors: Metzger BE

    更新日期:2007-12-01 00:00:00

  • Laparoscopy.

    abstract::Laproscopic sterilization techniques and the diagnostic use of laparoscopy are discussed. In a series of 1000 laparoscopic sterilizations by the 2-incision technique, there was a total failure rate, surgical and operative, of .4%. In a similar series with the 1-incision technique and electrocagulation only, the total...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/00003081-197606000-00004

    authors: Wheeless CR Jr

    更新日期:1976-06-01 00:00:00

  • Benign breast diseases: epidemiology, evaluation, and management.

    abstract::Benign breast diseases are common and encompass a spectrum of disorders. The majority of diagnoses will stem from a patient presenting with symptoms such as a mass or discomfort, or as a result of breast imaging which shows abnormalities leading to percutaneous biopsy. When mammographic and pathologic findings are dis...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/GRF.0b013e318208010e

    authors: Rungruang B,Kelley JL 3rd

    更新日期:2011-03-01 00:00:00

  • Physiology of amniotic fluid volume regulation.

    abstract::Although there are fairly wide variations AFV normally undergoes characteristic changes across gestation in which it increases from 10-20 ml at 10 weeks gestation to average 800 ml at 24 weeks. Little change occurs from then until near term when AFV begins to decrease, and large decreases can occur in postterm pregnan...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00003081-199706000-00005

    authors: Brace RA

    更新日期:1997-06-01 00:00:00

  • Controversies in Screening Mammography.

    abstract::The utility and effectiveness of screening mammography in diagnosing breast cancer at earlier stages and reducing disease-specific mortality remain controversial especially as to when to start and stop routine mammographic screening, and whether mammograms should be performed annually or biennially in average-risk wom...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/GRF.0000000000000205

    authors: Swain M,Jeudy M,Pearlman MD

    更新日期:2016-06-01 00:00:00

  • Oral misoprostol administration for labor induction.

    abstract::Using oral agents for induction of labor would reduce the need for repeated vaginal examinations; this is more acceptable to women and could reduce infection rates. A systematic review was conducted of 41 randomized trials comparing oral misoprostol to other induction agents. Oral misoprostol is effective at achieving...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00003081-200609000-00023

    authors: Weeks A,Alfirevic Z

    更新日期:2006-09-01 00:00:00

  • Conservative management of cervical intraepithelial neoplasia.

    abstract::A brief review of cervical intraepithelial neoplasia has been presented. Attempts have been made to identify the high-risk patient, and etiologic considerations have been detailed. The conservative management of cervical intraepithelial neoplasia is available and applicable to many patients. Regardless of the definiti...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00003081-198003000-00021

    authors: Creasman WT,Weed JC Jr

    更新日期:1980-03-01 00:00:00

  • Deep vein thrombosis and pulmonary embolism in pregnancy: diagnosis, complications, and management.

    abstract::Venous thromboembolism is a leading cause for maternal mortality. Because of the increase risk for thromboembolism in pregnancy and the postpartum period, the clinician must be on high alert for the signs and symptoms and use appropriate diagnostics in a timely manner so that prompt anticoagulation therapy can be init...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/GRF.0b013e3181deb27e

    authors: Brown HL,Hiett AK

    更新日期:2010-06-01 00:00:00

  • Cesarean section for fetal distress.

    abstract::The avoidance of neonatal medical and neurologic sequelae resulting from a compromised pregnancy, labor, or delivery is the goal of all members of the health care team. Correct identification of those patients at risk for fetal distress prior to as well as during labor is most important as a major step in achieving th...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/00003081-198528040-00010

    authors: Nageotte MP

    更新日期:1985-12-01 00:00:00

  • Prenatal programming of insulin secretion in intrauterine growth restriction.

    abstract::Intrauterine growth restriction (IUGR) impairs insulin secretion in humans and in animal models of IUGR. Several underlying mechanisms have been implicated, including decreased expression of molecular regulators of β-cell mass and function, in some cases shown to be due to epigenetic changes initiated by an adverse fe...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e31829e5b29

    authors: Gatford KL,Simmons RA

    更新日期:2013-09-01 00:00:00