Long-term outcomes in mothers diagnosed with gestational diabetes mellitus and their offspring.

Abstract:

:Mothers with gestational diabetes mellitus (GDM) are at high lifetime risk of developing type 2 diabetes mellitus. The magnitude of risk for cardiovascular disease after GDM is less well established. Recently, intervention trials using lifestyle modification or medications used to treat type 2 DM have successfully prevented/delayed development of DM in women after GDM. Offspring of mothers with GDM are at risk for development of obesity and abnormal glucose metabolism during childhood, adolescence, and adulthood. Factors responsible for these risks are not fully understood. Having fetal hyperinsulinism is a risk factor for development of both obesity and abnormal glucose metabolism, and might be implicated in pathophysiology. It remains to be established whether the long-term effects of exposure to diabetes mellitus during intrauterine development can be prevented.

journal_name

Clin Obstet Gynecol

authors

Metzger BE

doi

10.1097/GRF.0b013e31815a61d6

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

972-9

issue

4

eissn

0009-9201

issn

1532-5520

pii

00003081-200712000-00015

journal_volume

50

pub_type

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