Abstract:
:Beryllium is commonly used in the dental industry. This study investigates the association between particle size and shape in induced sputum (IS) with beryllium exposure and oxidative stress in 83 dental technicians. Particle size and shape were defined by laser and video, whereas beryllium exposure data came from self-reports and beryllium lymphocyte proliferation test (BeLPT) results. Heme oxygenase-1 (HO1) gene expression in IS was evaluated by quantitative polymerase chain reaction. A high content of particles (92%) in IS >5 μ in size is correlated to a positive BeLPT risk (odds ratio [OR] = 3.4, 95% confidence interval [CI]: 0.9-13). Use of masks, hoods, and type of exposure yielded differences in the transparency of IS particles (gray level) and modulate HO1 levels. These results indicate that parameters of size and shape of particles in IS are sensitive to workplace hygiene, affect the level of oxidative stress, and may be potential markers for monitoring hazardous dust exposures.
journal_name
Arch Environ Occup Healthjournal_title
Archives of environmental & occupational healthauthors
Stark M,Lerman Y,Kapel A,Pardo A,Schwarz Y,Newman L,Maier L,Fireman Edoi
10.1080/19338244.2012.744736subject
Has Abstractpub_date
2014-01-01 00:00:00pages
89-99issue
2eissn
1933-8244issn
2154-4700journal_volume
69pub_type
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