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The effects of human chorionic gonadotropin on growth and steroidogenesis of the human fetal adrenal gland in vitro.

Abstract：

:This study examined the effects of human chorionic gonadotropin, adrenocorticotropin, human luteinizing hormone, and mouse epidermal growth factor on growth (thymidine incorporation) and steroidogenesis (dehydroepiandrosterone sulfate production) of human fetal zone adrenal cells in monolayer culture. Two preparations of human chorionic gonadotropin extracted from pregnancy urine were used, one highly purified (National Institutes of Health, CR-121) and one less pure (Sigma). Thymidine incorporation was increased twofold to tenfold in cultures exposed to the Sigma human chorionic gonadotropin preparation or to mouse epidermal growth factor as compared to control. Pure National Institutes of Health human chorionic gonadotropin and luteinizing hormone had no effect on growth. When adrenocorticotropin was added alone or in combination with Sigma human chorionic gonadotropin or mouse epidermal growth factor, growth was decreased. Dehydroepiandrosterone sulfate production was stimulated by adrenocorticotropin but not by human luteinizing hormone, human chorionic gonadotropin, or mouse epidermal growth factor. These results suggest that human pregnancy urine contains a growth factor which remains to be identified but that pure human chorionic gonadotropin has no mitogenic or steroidogenic effects on the cultured fetal zone cells of the human fetal adrenal gland.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Abu-Hakima M,Branchaud CL,Goodyer CG,Murphy BE

doi

10.1016/0002-9378(87)90077-9

subject

Has Abstract

pub_date

1987-03-01 00:00:00

pages

681-7

issue

3

eissn

0002-9378

issn

1097-6868

pii

0002-9378(87)90077-9

journal_volume

156

pub_type

杂志文章

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