当前位置： SCI文献检索 > Applied Health Economics and Health Policy期刊下所有文献 > Did we see it Coming? An Evaluation of the Swedish Early Awareness and Alert System.

Did we see it Coming? An Evaluation of the Swedish Early Awareness and Alert System.

Abstract：

BACKGROUND:Early awareness and alert systems have been established in many countries but evidence on their ability to accurately prioritize new medicines (for early assessment) is limited. OBJECTIVE:The purpose of this study was to assess whether the Swedish Early Awareness and Alert System identified and prioritized (i.e., produced early assessment reports for) new medicines that would go on to have substantial economic impact. METHODS:We adapted a study design commonly used in the assessment of diagnostic test accuracy. The prioritization made by the Swedish Early Awareness and Alert System prior to marketing authorization comprised the index test and the national drug sales data in the second year post-authorization served as the reference standard. All initial marketing authorization applications for medicinal products processed by the European Medicines Agency between 2010 and 2015 (study population) were classified using the index test and the reference standard. RESULTS:Two hundred and fifty-three new medicinal products processed by the European Medicines Agency comprised the study population. Of these, 71 were prioritized by the Swedish Early Awareness and Alert System and 21 were classified as having substantial economic impact. The sensitivity and positive predictive value were 76.2% and 22.5%, respectively. Subgroup analyses showed that the accuracy of prioritization, in terms of sensitivity, was 100% for antineoplastic/immunomodulating agents. CONCLUSIONS:The Swedish Early Awareness and Alert System identified all new medicines that would go on to have substantial economic impact and prioritized most of these medicines. Our findings provide reassurance to decision makers who rely on the outputs of the Swedish Early Awareness and Alert System to keep informed about new medicines. Moreover, this study also provides valuable insights to stakeholders willing to establish or evaluate their own early awareness and alert activities and systems.

journal_name

Appl Health Econ Health Policy

journal_title

Applied health economics and health policy

authors

Eriksson I,von Euler M,Malmström RE,Godman B,Wettermark B

doi

10.1007/s40258-018-0434-2

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

93-101

issue

1

eissn

1175-5652

issn

1179-1896

pii

10.1007/s40258-018-0434-2

journal_volume

17

pub_type

杂志文章

相关文献

Applied Health Economics and Health Policy文献大全
  • Reducing smoking prevalence in Australian prisons: a review of policy options.

    abstract：:Smoking of tobacco products is a major public health challenge in prison settings in most countries. Although tobacco use was tolerated by custodial authorities for many decades, the overwhelming evidence of the adverse public health effects of tobacco on both the smokers and those in the vicinity of exhaled or passiv...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章,评审

    doi：

    authors： Awofeso N

    更新日期：2002-01-01 00:00:00

  • Health Insurance in Sub-Saharan Africa: A Scoping Review of the Methods Used to Evaluate its Impact.

    abstract：:We conducted a scoping review with the objective of synthesizing available literature and mapping what designs and methods have been used to evaluate health insurance reforms in sub-Saharan Africa. We systematically searched for scientific and grey literature in English and French published between 1980 and 2017 using...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章,评审

    doi：10.1007/s40258-019-00499-y

    authors： Degroote S,Ridde V,De Allegri M

    更新日期：2020-12-01 00:00:00

  • SecurAcath for Securing Peripherally Inserted Central Catheters: A NICE Medical Technology Guidance.

    abstract：:Central venous catheters are commonly used to deliver therapies and to monitor patients, and require securing at the point of percutaneous entry to avoid dislodgement. SecurAcath is a catheter securement device designed for central venous catheters. The National Institute for Health and Care Excellence, as a part of i...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章,评审

    doi：10.1007/s40258-018-0427-1

    authors： Macmillan T,Pennington M,Summers JA,Goddard K,Zala D,Herz N,Peacock JL,Keevil S,Chalkidou A

    更新日期：2018-12-01 00:00:00

  • Health State Utility Values for Age-Related Macular Degeneration: Review and Advice.

    abstract：:Health state utility values are a major source of uncertainty in economic evaluations of interventions for age-related macular degeneration (AMD). This review identifies and critiques published utility values and methods for eliciting de novo utility values in AMD. We describe how utility values have been used in heal...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章,评审

    doi：10.1007/s40258-016-0275-9

    authors： Butt T,Tufail A,Rubin G

    更新日期：2017-02-01 00:00:00

  • U.S. and International In-Hospital Costs of Extracorporeal Membrane Oxygenation: a Systematic Review.

    abstract：CONTEXT:The in-hospital costs of extracorporeal membrane oxygenation (ECMO) have not been well established. OBJECTIVE:To evaluate the in-hospital costs of ECMO technology in both US and non-US settings for all patient types. DATA SOURCES:Systematic review of English-language articles, using the PubMed, Embase, Web of...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章,评审

    doi：10.1007/s40258-015-0170-9

    authors： Harvey MJ,Gaies MG,Prosser LA

    更新日期：2015-08-01 00:00:00

  • Economic Evaluation of Community-Based Case Management of Patients Suffering From Chronic Obstructive Pulmonary Disease.

    abstract：OBJECTIVES:To analyse the cost effectiveness of community-based case management for patients suffering from chronic obstructive pulmonary disease (COPD). METHODS:The study took place in the third largest municipality in Denmark and was conducted as a randomised controlled trial with 12 months of follow-up. A total of ...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.1007/s40258-016-0298-2

    authors： Sørensen SS,Pedersen KM,Weinreich UM,Ehlers L

    更新日期：2017-06-01 00:00:00

  • Cost-efficacy analysis of the MONET trial using UK antiretroviral drug prices.

    abstract：BACKGROUND:In virologically suppressed patients, switching to darunavir/ritonavir (DRV/r) monotherapy maintains HIV RNA suppression, and could also lower treatment costs. OBJECTIVE:The purpose of this analysis was to calculate the potential cost savings from the use of DRV/r monotherapy in the UK. METHODS:In the MONE...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章,随机对照试验

    doi：10.2165/11592220-000000000-00000

    authors： Gazzard B,Hill A,Anceau A

    更新日期：2011-07-01 00:00:00

  • Implications of a data-driven approach to treatment with growth hormone in children with growth hormone deficiency and Turner syndrome.

    abstract：BACKGROUND:Response to growth hormone (GH) therapy may vary between individual patients. Therefore the use of GH in children should be closely monitored to avoid over, under, or ineffective treatment regimens. The treatment response can be evaluated using growth prediction models. In an effort to improve the accuracy o...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.1007/s40258-013-0030-4

    authors： Kaspers S,Ranke MB,Han D,Loftus J,Wollmann H,Lindberg A,Roelants M,Kleintjens J

    更新日期：2013-06-01 00:00:00

  • Organization and estimated patient-borne costs of oral anticoagulation therapy in Italy: results from a survey.

    abstract：BACKGROUND:The management of the large patient population in Italy receiving long-term oral anticoagulation therapy (OAT) poses organizational challenges that are traditionally approached with a centralized procedure, relying on hospital-based clinics and/or GPs. However, the availability of near-patient testing device...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.2165/11313890-000000000-00000

    authors： Pradelli L,Iannazzo S,Zaniolo O,Botrugno P

    更新日期：2010-01-01 00:00:00

  • Cost effectiveness of human papillomavirus-16/18 genotyping in cervical cancer screening.

    abstract：BACKGROUND:There is limited understanding of the health economic implications of cervical screening with human papillomavirus (HPV)-16/18 genotyping. OBJECTIVE:The aim of this study was to evaluate the cost effectiveness of cervical cancer primary screening with a HPV-16/18 genotyping test which simultaneously detects...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.1007/s40258-014-0135-4

    authors： Huh WK,Williams E,Huang J,Bramley T,Poulios N

    更新日期：2015-02-01 00:00:00

  • Cost and Budget Impact Analysis of an Accurate Intraoperative Sentinel Lymph Node Diagnosis for Breast Cancer Metastasis.

    abstract：BACKGROUND:Conventional intraoperative sentinel lymph node biopsy (SLNB) in breast cancer (BC) has limitations in establishing a definitive diagnosis of metastasis intraoperatively, leading to an unnecessary second operation. The one-step nucleic amplification assay (OSNA) provides accurate intraoperative diagnosis and...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.1007/s40258-016-0235-4

    authors： Saruta Y,Puig-Junoy J

    更新日期：2016-06-01 00:00:00

  • Virtual Touch™ Quantification to Diagnose and Monitor Liver Fibrosis in Hepatitis B and Hepatitis C: A NICE Medical Technology Guidance.

    abstract：:Virtual Touch™ Quantification (VTq) is a software application used with Siemens Acuson ultrasound scanners to assess the stiffness of liver tissue. The National Institute for Health and Care Excellence (NICE) Medical Technologies Advisory Committee (MTAC) selected VTq for evaluation and invited the company to submit c...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章,评审

    doi：10.1007/s40258-016-0277-7

    authors： Summers JA,Radhakrishnan M,Morris E,Chalkidou A,Rua T,Patel A,McMillan V,Douiri A,Wang Y,Ayis S,Higgins J,Keevil S,Lewis C,Peacock J

    更新日期：2017-04-01 00:00:00

  • A Case Study of Pharmaceutical Pricing in China: Setting the Price for Off-Patent Originators.

    abstract：:This article aims to define a value-based approach to pricing and reimbursement for off-patent originators using a multiple criteria decision analysis (MCDA) approach centered on a systematic analysis of current pricing and reimbursement policies in China. A drug price policy review was combined with a quantitative an...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章,评审

    doi：10.1007/s40258-014-0150-5

    authors： Hu S,Zhang Y,He J,Du L,Xu M,Xie C,Peng Y,Wang L

    更新日期：2015-08-01 00:00:00

  • How a Bottom-Up Multi-Stakeholder Initiative Helped Transform the Renal Replacement Therapy Landscape in Spain.

    abstract：:Healthcare reforms aim to change certain parts of the health system to improve quality of care, access, or financial sustainability. Traditionally, healthcare reform is understood as an action undertaken by a government at a national or local level. However, bottom-up changes can also lead to improvements in the healt...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.1007/s40258-017-0315-0

    authors： Selgas R,Rodriguez L,Julian JC,Remon C,Prieto-Velasco M,Perez-Contreras J,Fontan MP,GADDPE.

    更新日期：2017-12-01 00:00:00

  • Modelling the costs and outcomes of changing rates of screening for alcohol misuse by GPs in the Australian context.

    abstract：AIM:To assess the relative cost effectiveness of four strategies (academic detailing, computerised reminder systems, target payments and interactive continuing medical education) to increase the provision of screening and brief interventions by Australian GPs with the ultimate goal of decreasing risky alcohol consumpti...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.2165/00148365-200605030-00002

    authors： Shanahan M,Shakeshaft A,Mattick RP

    更新日期：2006-01-01 00:00:00

  • Level of Evidence in Economic Evaluations of Left Atrial Appendage Closure Devices: A Systematic Review.

    abstract：OBJECTIVES:The objective of the present work was to assess the level of evidence in economic evaluations of percutaneous left atrial appendage closure devices, and to test the complementarity of three different tools for assessing the quality of economic evaluations. METHODS:We conducted a systematic review of article...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.1007/s40258-018-0429-z

    authors： Nédellec E,Pineau J,Prognon P,Martelli N

    更新日期：2018-12-01 00:00:00

  • Financial Impact of Alternative Pricing Benchmarks for Physician-Dispensed Drugs in the California Workers' Compensation System.

    abstract：BACKGROUND:Pricing drugs in the California Workers' Compensation System (CAWCS) has become more difficult as there are increasingly fewer drugs listed in the Medi-Cal primary fee schedule, which is used as the source for CAWCS drug prices. This presents a challenge of providing timely and accurate CAWCS reimbursement. ...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.1007/s40258-018-0442-2

    authors： Wilson L,Turkistani F,Tran DM,Huang W,Lin TK

    更新日期：2019-04-01 00:00:00

  • Assessing the cost utility of response-guided therapy in patients with chronic hepatitis C genotype 1 in the UK using the MONARCH model.

    abstract：BACKGROUND:European guidelines advocate the measurement of on-treatment hepatitis C virus (HCV) RNA in order to determine optimal therapy duration (response-guided therapy [RGT]) in patients with rapid virological response (RVR) or delayed virological response (DVR). Treatment response is highly dependent upon the exte...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.1007/s40258-012-0002-0

    authors： McEwan P,Kim R,Yuan Y

    更新日期：2013-02-01 00:00:00

  • Financial risk of the biotech industry versus the pharmaceutical industry.

    abstract：:The biotech industry now accounts for a substantial and growing proportion of total R&D spending on new medicines. However, compared with the pharmaceutical industry, the biotech industry is financially fragile. This article illustrates the financial fragility of the biotech and pharmaceutical industries in the US and...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.1007/BF03256149

    authors： Golec J,Vernon JA

    更新日期：2009-01-01 00:00:00

  • The influence of bonus payments to doctors on hospital revenue: results of a quasi-experimental study.

    abstract：:There is wide consensus that the ways in which providers are reimbursed by third parties will affect their behaviour and, hence, the efficient use of limited resources and the performance of health systems. However, there seems to be little evidence on how payment to hospital-based doctors affects hospital performance...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：

    authors： Liu X,Mills A

    更新日期：2003-01-01 00:00:00

  • Cost effectiveness of self-monitoring of blood glucose (SMBG) for patients with type 2 diabetes and not on insulin: impact of modelling assumptions on recent Canadian findings.

    abstract：BACKGROUND:Canadian patients, healthcare providers and payers share interest in assessing the value of self-monitoring of blood glucose (SMBG) for individuals with type 2 diabetes but not on insulin. Using the UKPDS (UK Prospective Diabetes Study) model, the Canadian Optimal Prescribing and Utilization Service (COMPUS)...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.2165/11594270-000000000-00000

    authors： Tunis SL

    更新日期：2011-11-01 00:00:00

  • Economic Evaluations of Guideline-Based Care for Chronic Wounds: a Systematic Review.

    abstract：OBJECTIVES:The aim of this study was to review all published economic evaluations of guideline-based care for chronic wounds and to assess how useful these studies are for decision making in health services. METHODS:Embase, PubMed, Scopus, Health Technology Assessment (HTA) and National Health Service Economic Evaluat...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.1007/s40258-018-0403-9

    authors： Cheng Q,Graves N,Pacella RE

    更新日期：2018-10-01 00:00:00

  • Demand for outpatient healthcare: empirical findings from rural India.

    abstract：BACKGROUND:Price, income and health status are likely to affect the demand for healthcare in developing countries, and their quantitative effects are unclear in the literature. Some studies report that prices are not important determinants, while others conclude that prices are important determinants of the demand for ...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.1007/BF03256160

    authors： Sarma S

    更新日期：2009-01-01 00:00:00

  • The use of research abstracts in formulary decision making by the Joint Oncology Drug Review of Canada.

    abstract：BACKGROUND AND OBJECTIVE:Opinions on the use of research abstracts in policy decision making are conflicting. We sought to evaluate the influence of research abstracts in guiding decisions of the Joint Oncology Drug Review of Canada (JODR), which conducts clinical and economic reviews of new cancer treatment drugs for ...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.2165/11530510-000000000-00000

    authors： Weizman AV,Griesman J,Bell CM

    更新日期：2010-01-01 00:00:00

  • The lifetime cost of hepatocellular carcinoma : a claims data analysis from a medical centre in Taiwan.

    abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the second most common cancer in Taiwan. For males in Taiwan, it is the most dangerous cancer, with both the highest incidence and mortality rate. OBJECTIVE:To determine cancer-related medical care costs for long-term survivors of HCC. METHODS:The estimation of the lifetim...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.2165/00148365-200806010-00005

    authors： Lang HC,Wu JC,Yen SH,Lan CF,Wu SL

    更新日期：2008-01-01 00:00:00

  • The Cost and Outcome Effectiveness of Total Hip Replacement: Technique Choice and Volume-Output Effects Matter.

    abstract：BACKGROUND:Total hip replacement (THR) must be managed in a more sustainable manner. More cost-effective surgical techniques and the centralization/regionalization of services are two solutions. The former requires an assessment of newer minimally invasive and muscle-sparing surgical techniques. The latter necessitates...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.1007/s40258-016-0260-3

    authors： Goldstein JP,Babikian GM,Rana AJ,Mackenzie JA,Millar A

    更新日期：2016-12-01 00:00:00

  • The importance of proximity to death in modelling community medication expenditures for older people: evidence from New Zealand.

    abstract：BACKGROUND:Concerns about the long-term sustainability of health care expenditures (HCEs), particularly prescribing expenditures, has become an important policy issue in most developed countries. Previous studies suggest that proximity to death (PTD) has a significant effect on total HCEs, with its exclusion leading to...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.1007/s40258-014-0121-x

    authors： Moore PV,Bennett K,Normand C

    更新日期：2014-12-01 00:00:00

  • Informing disinvestment through cost-effectiveness modelling: is lack of data a surmountable barrier?

    abstract：:The mandatory nature of recommendations made by the National Institute for Health and Clinical Excellence (NICE) in the UK has highlighted inherent difficulties in the process of disinvestment in existing technologies to fund NICE-approved technologies. A lack of evidence on candidate technologies means that the proce...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.1007/BF03256137

    authors： Karnon J,Carlton J,Czoski-Murray C,Smith K

    更新日期：2009-01-01 00:00:00

  • Cost of Medicare for All: Review of the Estimates.

    abstract：:This paper critically evaluates the estimates of the cost of Medicare for All (M4A) in the USA. Six studies that estimate the 1-year total cost of M4A in the USA are reviewed. These studies find that M4A would increase national health spending by as much as 16.9% or decrease it by 20.0%, representing a range of estima...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章

    doi：10.1007/s40258-021-00636-6

    authors： Nyman JA

    更新日期：2021-01-25 00:00:00

  • A Systematic Review of Physicians' and Pharmacists' Perspectives on Generic Drug Use: What are the Global Challenges?

    abstract：BACKGROUND AND OBJECTIVES:Generic substitution has been introduced in most countries in order to reduce costs and improve access to drugs. However, regulations and the generic drugs available vary between countries. It is the prescriber or dispenser of the drug who is the final decision maker. Nevertheless, physicians'...

    journal_title：Applied health economics and health policy

    pub_type： 杂志文章,评审

    doi：10.1007/s40258-014-0145-2

    authors： Toverud EL,Hartmann K,Håkonsen H

    更新日期：2015-08-01 00:00:00