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The use of research abstracts in formulary decision making by the Joint Oncology Drug Review of Canada.

Abstract：

BACKGROUND AND OBJECTIVE:Opinions on the use of research abstracts in policy decision making are conflicting. We sought to evaluate the influence of research abstracts in guiding decisions of the Joint Oncology Drug Review of Canada (JODR), which conducts clinical and economic reviews of new cancer treatment drugs for formulary listing. METHODS:The minutes of the monthly meetings of the JODR between 2005 and 2007 were reviewed. One submission per drug indication was included. Elements evaluated included the level of evidence supporting each decision, the year the study was published and subsequent publication of any abstracts. RESULTS:There were 73 recommendations reviewed over the 36 months. Ten recommendations were deferred and eight recommendations were re-submissions, thus 55 recommendations underwent analysis. There were 31 recommendations based to some extent on abstracts, of which 14 (45%) were in favour of formulary listing and 17 (55%) were opposed. Twelve recommendations were based exclusively on abstracts, seven (58%) of which were in favour of formulary listing. As a comparison, published randomized controlled trials were part of the evidentiary base in 30 committee recommendations (55%). Of these, 17 (57%) were in favour of formulary listing, while 13 (43%) were opposed. CONCLUSIONS:Research abstracts are commonly involved in evidence-based decision making for formulary listing. The rates of approving cancer drugs for funding by the JODR were similar among recommendations based on abstracts and other levels of evidence. Abstracts can play an important role in guiding decision making.

journal_name

Appl Health Econ Health Policy

journal_title

Applied health economics and health policy

authors

Weizman AV,Griesman J,Bell CM

doi

10.2165/11530510-000000000-00000

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

387-91

issue

6

eissn

1175-5652

issn

1179-1896

pii

6

journal_volume

8

pub_type

杂志文章

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