An epidemic of hepatitis A in an institution for young children.

Abstract:

:A common-source epidemic of hepatitis A occurred in an Athenian institution boarding 38 children (mean age 4.8 years). All children were examined, and blood was drawn from each at the onset of the study and repeatedly during the next three months. Only one child (2.6%) was initially immune to hepatitis A virus as a result of prior infection. The attack rate (62.2%) and the ratio of icteric to anicteric cases (1:1.3) were high despite the administration of immunoglobulin (IG). Assays for anti-HAV IgM and a rising titer of anti-HAV IgG identified 19 (82.6%) and 22 (95.7%) of the 23 hepatitis A infections, respectively. One case (4.3%) was detected only by the presence of hepatitis A virus antigen and hepatitis A virus RNA in a fecal specimen, but these assays were otherwise marginally useful in this study. Nevertheless, the use of all available tests for the detection of hepatitis A virus is mandatory for the most accurate estimation of an epidemic of hepatitis A. Prompt administration of immunoglobulin had no effect on the number of clinical cases that were in the late incubation period, but it may have diminished the clinical expression of the infection and thus made diagnosis of infection more difficult.

journal_name

Am J Epidemiol

authors

Tassopoulos NC,Roumeliotou-Karayannis A,Sakka M,Ticehurst J,Mihalik K,Stephanou T,Purcell RH,Papaevangelou G

doi

10.1093/oxfordjournals.aje.a114530

subject

Has Abstract

pub_date

1987-02-01 00:00:00

pages

302-7

issue

2

eissn

0002-9262

issn

1476-6256

journal_volume

125

pub_type

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