Abstract：
:Few studies have examined the role of endogenous sex hormones in breast cancer, and to the authors' knowledge, only two have done so prospectively. The authors report here the results of a prospective study based on an available bank of previously analyzed plasma collected in 1972-1974 from 442 women aged 50-79 years in Rancho Bernardo, California. These women were followed for 12-15 years, during which time 42 cases of breast cancer were identified: 15 incident cases diagnosed 1 year or more after baseline, 18 prevalent cases diagnosed earlier than 1 year after baseline, and 9 cases with unknown dates of onset. No apparent trends in plasma levels of sex hormones or sex hormone-binding globulin and incidence or prevalence of breast cancer were observed. Mean crude and age-adjusted plasma hormone levels at baseline (in pg/ml) for incident cases, total cases, and noncases, respectively, were: androstenedione: 647, 638 +/- 328 (standard deviation); 626, 620 +/- 245; and 664, 664 +/- 291; testosterone: 254, 258 +/- 120; 238, 241 +/- 153; and 262, 261 +/- 143; estrone: 37, 38 +/- 18; 35, 35 +/- 15; and 37, 37 +/- 17, and estradiol: 13, 13 +/- 7; 15, 15 +/- 8; and 15, 15 +/- 9. For sex hormone-binding globulin, mean crude and age-adjusted levels at baseline (nM) were 35 and 36 +/- 33 for incident cases; 31 and 31 +/- 25 for total cases; and 29 and 29 +/- 21 for noncases. Cox proportional hazards multiple regression showed no associations with breast cancer after simultaneous adjustment for age, body mass index, and cigarette smoking.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Garland CF,Friedlander NJ,Barrett-Connor E,Khaw KTdoi
10.1093/oxfordjournals.aje.a116228subject
Has Abstractpub_date
1992-06-01 00:00:00pages
1220-30issue
11eissn
0002-9262issn
1476-6256journal_volume
135pub_type
杂志文章abstract：:Rhinovirus infections in Seattle families with schoolchildren (1975-1979) and in selected outpatients were revealed by virus shedding or antibody rise. These observations extend those in the Seattle Virus Watch (1965-1969). Analysis of rhinovirus serotype prevalence again revealed certain "common" persisting serotypes...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114166
更新日期：1985-11-01 00:00:00
abstract：:The identification of the environmental factors causing insulin-dependent diabetes in children has remained elusive. However, evidence is rapidly accumulating that childhood diabetes exhibits epidemic patterns, much like that seen with an infectious disease. It is likely that within these epidemics the environmental d...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:Differences in hygienic habits and base-line secretory immunoglobulin (Ig) A which might have contributed to the prevalence of skin infections and/or absence of increased serum IgA values were sought in patients with poststreptococcal acute glomerulonephritis (nephritis) in contrast to patients with acute rheumatic fe...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a113382
更新日期：1982-06-01 00:00:00
abstract：:Soft drinks and other sweetened beverages may contribute to risk of type 2 diabetes and obesity. However, research has not addressed higher risk and Asian populations. The authors examined the association between soft drinks and juice and the risk of type 2 diabetes among Chinese Singaporeans enrolled in a prospective...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwp452
更新日期：2010-03-15 00:00:00
abstract：:The true number of industrial accidents followed by absence from work in the Netherlands in 1993 has been estimated by using a capture-recapture approach. A government safety register noted 29,685 cases reported by Dutch companies. The statutory organization that insures employees of the same companies against absence...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a009622
更新日期：1998-07-15 00:00:00
abstract：:Physical functioning measures are considered integrated markers of the aging process. This prospective investigation examined relations between dietary intake of women at midlife in 1996-1997 and prevalence of physical functioning limitations 4 years later, defined by the Medical Outcomes Study Short-Form 36. The samp...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwm397
更新日期：2008-04-15 00:00:00
abstract：:Early-onset cannabis use is widespread in many countries and might cause later onset of depression. Sound epidemiologic data across countries are missing. The authors estimated the suspected causal association that links early-onset (age <17 years) cannabis use with later-onset (age > or =17 years) risk of a depressio...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwq096
更新日期：2010-07-15 00:00:00
abstract：:The authors investigated the relations of body mass index at different ages and adult weight change to incident colorectal cancer risk in the prospective National Institutes of Health-AARP Diet and Health Study (1995-1996), using a subcohort with repeated recall weights (273,679 participants; mean baseline age = 62.8 ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kws192
更新日期：2012-12-15 00:00:00
abstract：:The relative contribution of menopause to the age-related increase in serum total cholesterol concentration in women is not exactly known. Cross-sectional studies suggest a considerable contribution of menopause, whereas in short-term longitudinal studies, only a small increase was observed around menopause. In a 10-y...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a116686
更新日期：1993-02-15 00:00:00
abstract：:A common-source epidemic of hepatitis A occurred in an Athenian institution boarding 38 children (mean age 4.8 years). All children were examined, and blood was drawn from each at the onset of the study and repeatedly during the next three months. Only one child (2.6%) was initially immune to hepatitis A virus as a re...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114530
更新日期：1987-02-01 00:00:00
abstract：:The authors report the results of the first 2 years of follow-up of a prospective cohort study on the mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) and its determinants which started in November 1988 in Kigali, Rwanda. The study sample consists of 218 newborns of 215 HIV-1 seropositive wo...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a116716
更新日期：1993-03-15 00:00:00
abstract：:An inverse association between socioeconomic status, as measured by years of education, and blood pressure has been reported in a number of studies. However, two secular trends may have changed the nature of this relation: a higher mean level of education in the population and intervention for high blood pressure in t...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a116245
更新日期：1992-06-15 00:00:00
abstract：:Although the percentage of US drivers with valid driver's licenses varies from state to state, it has historically been high enough to constitute a useful sampling frame for many public health purposes. Over the past decade, states have had to restrict access to this information to comply with the Driver's Privacy Pro...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwr018
更新日期：2011-06-15 00:00:00
abstract：:One frequently analyzes a subset of the data collected in a survey when interest focuses on individuals in a certain subpopulation of the sampled population. Although it may seem natural to eliminate from the data set all data from individuals outside the subpopulation before analysis, this procedure may yield incorre...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a008847
更新日期：1996-07-01 00:00:00
abstract：:Several studies have reported associations between airborne particles and/or ozone and hospital admissions for respiratory disease. This study examined whether such an association could be seen in Birmingham, Alabama, one of the few cities in the United States with daily monitoring of inhalable particles. Daily counts...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a117048
更新日期：1994-03-15 00:00:00
abstract：:A case-control epidemiologic study of childhood polymyositis is presented. Parents of 42 cases of childhood polymyositis were interviewed along with parents of controls matched for sex and age. Extensive review of past medical history, animal exposure history, residential and family history, and immunization history f...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112341
更新日期：1976-12-01 00:00:00
abstract：:Emergency medical services with advanced life support systems were implemented in the Minneapolis-St. Paul, Minnesota, area in the mid-1970s. To assess the impact of emergency medical services on coronary heart disease mortality, the authors reviewed ambulance records and hospital emergency room logs for possible out-...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a116160
更新日期：1991-10-15 00:00:00
abstract：:This longitudinal study examines the transition to adulthood in a randomly sampled, community-based cohort of adolescents. The study compares young adult outcomes of 33 adolescents with and 148 adolescents without psychiatric disorder. After adjustment for differences in age, gender, and social class, adolescents with...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/152.4.352
更新日期：2000-08-15 00:00:00
abstract：:Racial differences in the incidence and natural history of insulin-dependent diabetes mellitus were evaluated in Allegheny County, Pennsylvania. The yearly incidence rate for whites was approximately 1.5 times that for blacks. The cumulative risk of developing insulin-dependent diabetes prior to age 20 was greater for...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114279
更新日期：1986-04-01 00:00:00
abstract：:Data from a Norwegian investigation on family planning were used to study the relation between menarcheal age and spontaneous abortion rate. Abortion rates were found to be 1.5-2 times higher among women with a menarcheal age of 12 years or less than among those with a menarcheal age of 14 years or more. The possibili...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112953
更新日期：1980-06-01 00:00:00
abstract：:An episode is described in which tissue culture in a laboratory could have become intoxicated due to the recirculation of toxic exhaust fumes extruded from the roof of a research institution. A route of entry was found whereby a portion of fume hood exhaust was reintroduced into the building by means of large intake f...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a113094
更新日期：1981-03-01 00:00:00
abstract：:Although it is generally believed that a simple lifestyle may promote health, a recent study among Trappist and Benedictine monks in the Netherlands reported an increase in general morbidity (Am J Epidemiol 1993;138:569-73). As this increased morbidity might be the consequence of an increased life expectancy, we studi...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a117500
更新日期：1995-04-15 00:00:00
abstract：:This paper reports the results of an investigation of the acute effects of air pollution in 321 nonsmoking adults residing in Southern California. Previous epidemiologic investigations of effects of acute exposure to ozone have focused on groups who may not be representative of the general public, such as asthmatics o...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a116729
更新日期：1993-04-01 00:00:00
abstract：:In 1999, the authors began recruitment for a randomized controlled intervention trial aimed at preventing melanocytic nevi (moles) by minimizing sun exposure through the use of sun-protective clothing. The study involves 652 Caucasian children (75.6% response) aged 0-35 months from 25 child-care centers (n = 13 interv...
journal_title：American journal of epidemiology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1093/aje/kwi081
更新日期：2005-03-15 00:00:00
abstract：:The association of asthma with occupational exposures was studied in 14,151 adults, aged 25-59 years, from the general population of the 1975 French Pollution Atmospherique et Affections Respiratoires Chroniques (PAARC) Survey. Associations of asthma with specific jobs, such as personal care workers, waiters, and stoc...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwh316
更新日期：2004-12-01 00:00:00
abstract：:In the study of complex diseases, it may be important to test hypotheses related to gene-gene (G x G) interaction. The success of such studies depends critically on obtaining adequate sample sizes. In this paper, the author investigates sample size requirements for studies of G x G interaction, focusing on four study ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/155.5.478
更新日期：2002-03-01 00:00:00
abstract：:Although type 2 diabetes (T2D) predicts glaucoma, the potential for unmeasured confounding has hampered causal conclusions. We performed separate sample genetic instrumental variable analyses using the Genetic Epidemiology Research Study on Adult Health and Aging cohort (n = 69,685; 1995-2013) to estimate effects of T...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwv204
更新日期：2016-01-15 00:00:00
abstract：:A consistent framework has been developed for measuring health disparities and making comparisons across indicators with regard to the public health goals of Healthy People 2010. Disparities are measured as the percent difference from the best group rate, with all indicators being expressed in terms of adverse events....
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwm044
更新日期：2007-07-01 00:00:00
abstract：:Growing knowledge about gene-disease associations will lead to new opportunities for genetic testing. Many experts predict that genetic testing will become increasingly important as a guide to prevention, clinical management, and drug treatment based on genetic susceptibilities. As part of a Human Genetic Epidemiology...
journal_title：American journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1093/aje/kwf055
更新日期：2002-08-15 00:00:00
abstract：:The authors evaluated the association of complexity of work with data, people, and things with the incidence of dementia, Alzheimer's disease, and vascular dementia in the Canadian Study of Health and Aging, while adjusting for work-related physical activity. The Canadian Study of Health and Aging is a 10-year populat...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwm382
更新日期：2008-04-01 00:00:00
