Abstract:
:Antiarrhythmic efficiency and specific effects of ethmozine, taken alone in increasing oral doses from 300 to 450 mg daily, were evaluated in 48 elderly and old coronary patients with stable supraventricular and ventricular extrasystoles (SVES, VES). It was demonstrated clinically and instrumentally (ECG, rhythmography, bicycle ergometry with standard exercise, cardiac rhythm monitoring and computer analysis, polycardiography, tetrapolar chest rheography) that ethmozine's antiarrhythmic effect was marked (a more than 75% post-treatment decline in the frequency of extrasystoles at rest and during exercise, provided that paired polytopic extrasystoles and paroxysms of tachycardia are suppressed completely) in 52.1% of SVES patients and 60% of VES patients. Antiarrhythmic action of a 300 mg ethmozine load dose was particularly apparent within 2-7 hours after administration. Ethmozine treatment, as described above, delayed atrioventricular conduction, causing however no significant decrease in heart rate, nor depressing cardiac output and myocardial function; arterial blood pressure and myocardial oxygen requirement remained basically unchanged either. Unlike propranolol effect on cardiac rhythm undulating pattern, there is evidence that ethmozine mechanism of action involves sympathetic activation. Ethmozine had to be discontinued in 10.4% of the 35.4% of patients with side effects.
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Korkushko OV,Butenko AG,Kaukenas IKsubject
Has Abstractpub_date
1986-01-01 00:00:00pages
65-70issue
6eissn
0040-3660issn
2309-5342journal_volume
58pub_type
杂志文章abstract:AIM:To evaluate alterations in the immune system (IS) in patients with different forms of secondary immunodeficiency and design of differentiated programs of reestablishment of defective functions depending on pathogenetically important type of deficiency of immunocompetent cells. MATERIALS AND METHODS:Clinicoimmunolo...
journal_title:Terapevticheskii arkhiv
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doi:
更新日期:2001-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::The paper considers the consequences and causes of magnesium deficiency in patients with cardiovascular diseases. The features of magnesium metabolism in atherosclerosis, hypertension, and heart failure are described. Prospects of magnesium therapy in cardiology practice are discussed. ...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章,评审
doi:10.17116/terarkh20148612104-106
更新日期:2014-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
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更新日期:1984-01-01 00:00:00
abstract::The effect of the plasma obtained before and after graded submaximal exercise was examined in 10 bronchial asthma patients with the syndrome of asthma of physical effort (APE) by means of fluorescent exploration using the cation probe 4-(p-demethylaminostyryl)-1-methylpyridinum and rat thymocytes as a test system. Fou...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract:AIM:To study subclinical signs of cerebrovascular pathology as prognostic factors of development of acute disorders of cerebral circulation (ADCC) in essential hypertension (EH). MATERIAL AND METHODS:A prospective (10-13 years) cohort trial of prognostic significance of subclinical forms of cerebral pathology in EH in...
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pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:10.26442/terarkh2018901118-23
更新日期:2018-11-21 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
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更新日期:2019-11-15 00:00:00
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更新日期:2015-01-01 00:00:00
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pub_type: 社论
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更新日期:2010-01-01 00:00:00
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pub_type: 社论
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更新日期:2012-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章,评审
doi:
更新日期:2012-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00