An In Vitro Model for Identifying Cardiac Side Effects of Anesthetics.

Abstract:

:The understanding of anesthetic side effects on the heart has been hindered by the lack of sophisticated clinical models. Using micropatterned human-induced pluripotent stem cell-derived cardiomyocytes, we obtained cardiac muscle depressant profiles for propofol, etomidate, and our newly identified anesthetic compound KSEB01-S2. Propofol was the strongest depressant among the 3 compounds tested, exhibiting the largest decrease in contraction velocity, depression rate, and beating frequency. Interestingly, KSEB01-S2 behaved similarly to etomidate, suggesting a better cardiac safety profile. Our results provide a proof-of-concept for using human-induced pluripotent stem cell-derived cardiomyocytes as an in vitro platform for future drug design.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Chang ACY,Chang ACH,Nicin L,Weber GJ,Holbrook C,Davies MF,Blau HM,Bertaccini EJ

doi

10.1213/ANE.0000000000003757

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

e1-e4

issue

1

eissn

0003-2999

issn

1526-7598

journal_volume

130

pub_type

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