Reexamination of histological findings of ileal sarcomas induced in rats given diet containing bracken fern.

abstract：PURPOSE:Alzheimer disease (AD) and cancer are seemingly two opposite ends of one spectrum. Studies have suggested that patients with AD showed a reduced risk of cancer and vice versa. However, available evidences are not conclusive. So we conducted a meta-analysis using published literatures to systematically examine c...

journal_title：Journal of cancer research and clinical oncology

authors： Shi HB,Tang B,Liu YW,Wang XF,Chen GJ

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:Metastatic renal cell carcinoma (mRCC) sometimes presents with an indolent course without any significant symptoms. Here, the potential impact of active surveillance (AS) on clinical outcomes in asymptomatic or minimally symptomatic mRCC patients was retrospectively evaluated. METHODS:mRCC patients who were fo...

journal_title：Journal of cancer research and clinical oncology

authors： Park I,Lee JL,Ahn JH,Lee DH,Lee KH,Jeong IG,Song C,Hong B,Hong JH,Ahn H

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Targeted treatment of chronic myelogenous leukemia using imatinib has dramatically improved patient outcome. However, residual disease can be detected in the majority of patients treated with imatinib. Compensatory activation of MAP kinases (MAPK1/2) in response to BCR-ABL-inhibitors has been reported as a p...

journal_title：Journal of cancer research and clinical oncology

authors： Härtel N,Klag T,Hanfstein B,Mueller MC,Schenk T,Erben P,Hochhaus A,La Rosée P

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:Clinical trials have reported conflicting results as to whether taxane-based doublet improves outcome over single-agent taxane in patients with advanced breast cancer. METHODS:We performed a meta-analysis comparing primary and secondary end points of taxane-based doublet with single-agent taxane chemotherapy i...

journal_title：Journal of cancer research and clinical oncology

authors： Xu HB,Xu Q,Li L

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:Individuals affected by rheumatoid arthritis (RA) occasionally develop lymphoproliferative disorders (RA-LPD). To study the molecular changes underscoring the RA-LPD, mutations of p53 and Bak gene were analyzed in RA-LPD with (MTX-LPD) or without methotrexate treatment for RA (non-MTX-LPD). METHODS:Histology a...

journal_title：Journal of cancer research and clinical oncology

authors： Xu JX,Hoshida Y,Hongyo T,Sasaki T,Miyazato H,Tomita Y,Aozasa K

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVES:Tobacco exposure remains the main etiologic factor for lung cancer (LC). Interactions between environment and individual genetic profile are particularly important for this disease. The aim of this study was to evaluate the contribution of CYP1A1*2A, CYP1A1*2C, CYP2D6*4, GSTP1, GSTM1, GSTT1 and NAT2 polymorp...

journal_title：Journal of cancer research and clinical oncology

authors： Mota P,Silva HC,Soares MJ,Pego A,Loureiro M,Cordeiro CR,Regateiro FJ

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Ultrasound (US)-guided breast biopsy is a routine diagnostic method used to correlate imaging finding to a histological diagnosis which is still the gold standard in preoperative diagnostics. The accuracy of US-guided breast biopsies relies on a precise radiologic-histopathologic correlation, which is discus...

journal_title：Journal of cancer research and clinical oncology

authors： Jörg I,Wieler J,Elfgen C,Bolten K,Hutzli C,Talimi J,Vorburger D,Choschzick M,Moskovszky L,Dedes K,Varga Z

更新日期：2020-12-07 00:00:00

abstract：PURPOSE:Significant prolongation of overall survival (OS) has been reached in metastatic colorectal cancer (mCRC) treatment within the last 5-10 years. Our study was conducted in order to evaluate and compare OS of different standard of care treatment options in a university-based outpatient clinic. METHODS:One hundre...

journal_title：Journal of cancer research and clinical oncology

authors： Moehler M,Thomaidis T,Zeifri C,Barhoom T,Marquardt J,Ploch P,Schattenberg J,Maderer A,Schimanski CC,Weinmann A,Woerns MA,Kranich AL,Warnecke JM,Galle PR

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:This study aimed to determine the dose effect of smoking on the mutational frequency and spectrum of epidermal growth factor receptor (EGFR) gene in Korean non-small cell lung cancer (NSCLC). METHODS:Detailed smoking histories were obtained from 324 consecutively enrolled Korean NSCLC patients. Mutational stat...

journal_title：Journal of cancer research and clinical oncology

authors： Lee YJ,Shim HS,Kang YA,Hong SJ,Kim HK,Kim H,Kim SK,Choi SH,Kim JH,Cho BC

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:Lung cancer is the commonest cause of cancer deaths worldwide, and its mortality can be reduced significantly by performing early diagnosis and screening. Since the 1960s, driven by the pressing needs to accurately and effectively interpret the massive volume of chest images generated daily, computer-assisted d...

journal_title：Journal of cancer research and clinical oncology

authors： Liu B,Chi W,Li X,Li P,Liang W,Liu H,Wang W,He J

更新日期：2020-01-01 00:00:00

abstract：:In supporting the human-tumor cloning effort of the Southwest Oncology Group, we conducted an independent retrospective study to evaluate the clinical correlations of the soft-agar colony-forming assay developed by Hamburger and Salmon (1977). This study was made with the cooperation of 76 clinicians and 11 hospitals ...

journal_title：Journal of cancer research and clinical oncology

authors： Fan D,Morgan LR,Schneider C,Blank H,Fan S

更新日期：1985-01-01 00:00:00

abstract：:High-dose chemotherapy with peripheral blood stem cell transplantation (PBSCT) has become an important method of treatment for hematological and solid tumors. We examined levels of interleukin(IL)-4, interferon (IFN)gamma, soluble (s) CD30, and sIL-2 receptor (R) before and after autologous PBSCT, and compared finding...

journal_title：Journal of cancer research and clinical oncology

authors： Nagahama M,Nomura S,Katsura K,Ozaki Y,Yoshimura C,Kagawa H,Fukuhara S

更新日期：2000-02-01 00:00:00

abstract：:Concentrations of a fragment of the c-erbB-2 translational product (p185 fragment) were measured in serum of 70 breast cancer patients, 19 healthy blood donors, and 18 pregnant women using a heterogenic enzyme immunoassay. The serum concentrations of blood donors and pregnant women were below 30 kU/l. Breast cancer pa...

journal_title：Journal of cancer research and clinical oncology

authors： Kynast B,Binder L,Marx D,Zoll B,Schmoll HJ,Oellerich M,Schauer A

更新日期：1993-01-01 00:00:00

abstract：:The chemosensitizing potency of dexniguldipine hydrochloride (B8509-035) on epidoxorubicin was assessed in a multidrug-resistant (MDR) tumour model, the intrinsic MDR rat colon carcinoma CC531. In vitro in the sulphorhodamine B cell-viability assay the cytotoxicity of epidoxorubicin was increased approximately 15-fold...

journal_title：Journal of cancer research and clinical oncology

authors： Van de Vrie W,Schellens JH,Loss WJ,Kolker HJ,Verwey J,Stoter G,Durante NM,Eggermont AM

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVES:Due to PSA screening and increased awareness, prostate cancer (PCa) is identified earlier resulting in smaller diagnostic samples on prostate needle biopsy. Because Gleason grading plays a critical role in treatment planning, we undertook a controlled study to evaluate interobserver variability among German ...

journal_title：Journal of cancer research and clinical oncology

authors： Burchardt M,Engers R,Müller M,Burchardt T,Willers R,Epstein JI,Ackermann R,Gabbert HE,de la Taille A,Rubin MA

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:To calculate the accuracy of the Tokuhashi score (TS) in recent patients with vertebral metastasis (VM), candidates or not to surgical treatment, and thus to assess the external validity of TS. METHODS:Retrospective analysis of prospectively collected data from 90 patients (55 men, 35 women) with VM between 20...

journal_title：Journal of cancer research and clinical oncology

authors： Hernandez-Fernandez A,Vélez R,Lersundi-Artamendi A,Pellisé F

更新日期：2012-09-01 00:00:00

abstract：:A transplantable non-immunogenic murine carcinoma of spontaneous origin, WHT Carcinoma N-C (Hewitt), was used to assess the effectiveness of melphalan (Ml) and/or methotrexate (Mx) for treatment of occult metastatic disease following surgical excision of primary tumors. Early surgical excision alone cured 66% of mice;...

journal_title：Journal of cancer research and clinical oncology

authors： Zebro T,Wright EA

更新日期：1980-01-01 00:00:00

abstract：PURPOSE:The antimalarial agent, artemisinin, also confers cancer-specific cytotoxic effects by reacting with ferrous iron atoms to form free radicals. Here, we investigated the radiosensitizing effects of dihydroartemisinin on glioma cells and assessed some possible mechanisms for these effects. MATERIALS AND METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Kim SJ,Kim MS,Lee JW,Lee CH,Yoo H,Shin SH,Park MJ,Lee SH

更新日期：2006-02-01 00:00:00

abstract：:Adenocarcinomas of the lungs show a variable histology. We have subclassified such lesions into five cell types: hobnail, columnar, polygonal, mixed and goblet cell types, and investigated their relationships with K-ras mutations. Codons 12, 13 and 61 of the K-ras gene in 120 surgically resected pulmonary adenocarcino...

journal_title：Journal of cancer research and clinical oncology

authors： Tsuchiya E,Furuta R,Wada N,Nakagawa K,Ishikawa Y,Kawabuchi B,Nakamura Y,Sugano H

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:The clinical behaviour and outcome of young patients with gastroesophageal tumours (GET) is surmised to differ from older patients, yet data on the comparison of these two patient subgroups is scarce. This study focuses on the investigation of the clinical characteristics and survival outcome of younger-age ...

journal_title：Journal of cancer research and clinical oncology

authors： Puhr HC,Karner A,Taghizadeh H,Jomrich G,Schoppmann SF,Preusser M,Ilhan-Mutlu A

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:De novo malignancy is a worrying complication after kidney transplantation; the type of which may vary due to factors such as the prevalence of viral infection and race. Kaposi sarcoma used to be the most common malignancy among our patients constituting more than one-third of cancers. Nevertheless, we notic...

journal_title：Journal of cancer research and clinical oncology

authors： Donia AF,Fouda MA,Ghoneim ME,Refaie AF,Ali-El-Dein B

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:The TNM classification is used to assess cancers of the oral cavity, and advancements in imaging techniques have revealed clear variations in tumor volume at presentation. This study therefore aimed to clarify whether preoperative imaging, with exact measurements of the tumor, could affect post-surgery survival...

journal_title：Journal of cancer research and clinical oncology

authors： Mücke T,Mitchell DA,Ritschl LM,Tannapfel A,Wolff KD,Kesting MR,Loeffelbein DJ,Kanatas A

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:CC chemokine receptor 1 (CCR1) plays a critical role in the recruitment of leukocytes to the site of inflammation. Tumor invasion and metastasis share many similarities with leukocyte trafficking, which is critically regulated by chemokines and their receptors. In this study, we aimed to assess the role of CCR1...

journal_title：Journal of cancer research and clinical oncology

authors： Wang CL,Sun BS,Tang Y,Zhuang HQ,Cao WZ

更新日期：2009-05-01 00:00:00

abstract：:The complex problem of drug resistance is discussed with respect to host toxicity, to tumor characteristics (kinetic resistance, heterogeneity of cell subpopulations, hypoxia, mutation and gene amplification), and to the medication itself (pharmacokinetic and pharmacodynamic resistance: cell membrane, intracellular me...

journal_title：Journal of cancer research and clinical oncology

authors： Cazin JL,Gosselin P,Cappelaere P,Robert J,Demaille A

更新日期：1992-01-01 00:00:00

abstract：:The responsiveness of spleen cells from C57BL/6J mice to various immunogenic stimuli was examined during the progressive growth of a poorly immunogenic fibrosarcoma T241. A strong correlation was observed between the progressive tumor growth and the depression of response to Concanavalin A, lipopolysaccharide, sheep r...

journal_title：Journal of cancer research and clinical oncology

authors： Gautam SC,Gautam S,Deodhar SD

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:Patients with metastatic nonseminomatous germ cell tumors (mNSGCT) and a high tumor burden or a poor performance status at initial diagnosis are at risk from potentially life-threatening early complications during or after the first chemotherapy cycle. The outcomes with dose-reduced first cycle of chemotherapy ...

journal_title：Journal of cancer research and clinical oncology

authors： Tryakin A,Fedyanin M,Bulanov A,Kashia S,Kurmukov I,Matveev V,Fainstein I,Gordeeva O,Zakharova T,Tjulandin S

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:To evaluate prognostic factors in estrogen receptor (ER)-positive, operable breast cancer focusing on the progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). PATIENTS AND METHODS:A total of 819 patients with ER-positive, operable breast cancer were enrolled. All patients received up...

journal_title：Journal of cancer research and clinical oncology

authors： Moon YW,Park S,Sohn JH,Kang DR,Koo JS,Park HS,Chung HC,Park BW

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:To associate the global gene expression of B7/CD28 family transcripts with pathologic features of colon cancer, we determined the B7/CD28 family transcripts in peripheral blood mononuclear cells (PBMCs) from normal subjects and patients with adenomatous polyps and colon cancer, and correlated the results with p...

journal_title：Journal of cancer research and clinical oncology

authors： Lee H,Kim JH,Yang SY,Kong J,Oh M,Jeong DH,Chung JI,Bae KB,Shin JY,Hong KH,Choi I

更新日期：2010-09-01 00:00:00

abstract：:Point mutations occurring at codon 201 of the gene coding for the alpha subunit of the stimulatory G protein impair intrinsic GTPase activity and lead to a constitutive activation of adenylate cyclase. We have examined thyroid follicular and papillary carcinomas and follicular adenomas and found samples that bear this...

journal_title：Journal of cancer research and clinical oncology

authors： Gorelov VN,Dumon K,Barteneva NS,Palm D,Röher HD,Goretzki PE

更新日期：1995-01-01 00:00:00

abstract：:The proliferative activity in 70 cases of soft-tissue tumours was estimated immunohistochemically using the monoclonal antibody PC-10, which recognizes proliferating-cell nuclear antigen (PCNA) in paraffin sections. The PCNA index (i.e. the percentage of positive neoplastic nuclei) and to a lesser degree the PCNA coun...

journal_title：Journal of cancer research and clinical oncology

authors： Korkolopoulou P,Christodoulou P,Papanikolaou A,Tsenga A,Thomas-Tsagli E

更新日期：1994-01-01 00:00:00