Abstract:
:The importance of antibodies in activating immune responses against tumors is now better appreciated with the emergence of checkpoint blockade antibodies and with engineered antibody Fc domains featuring enhanced capacity to focus potent effector cells against cancer cells. Antibodies designed with Fc regions of the IgE class can confer natural, potent, long-lived immune surveillance in tissues through tenacious engagement of high-affinity cognate Fc receptors on distinct, often tumor-resident immune effector cells, and through ability to activate these cells under tumor-induced Th2-biased conditions. Here, we review the properties that make IgE a contributor to the allergic response and a critical player in the protection against parasites, which also support IgE as a novel anti-cancer modality. We discuss IgE-based active and passive immunotherapeutic approaches in disparate in vitro and in vivo model systems, collectively suggesting the potential of IgE immunotherapies in oncology. Translation toward clinical application is now in progress.
journal_name
MAbsjournal_title
mAbsauthors
Josephs DH,Spicer JF,Karagiannis P,Gould HJ,Karagiannis SNdoi
10.4161/mabs.27029subject
Has Abstractpub_date
2014-01-01 00:00:00pages
54-72issue
1eissn
1942-0862issn
1942-0870pii
27029journal_volume
6pub_type
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